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J C Araya

Publications and source records attributed to J C Araya.

72 records · Page 4Linked to original sources
PubMed1991

[Inapparent cancer of the gallbladder].

Gallbladder cancer is the most common cancer in the Chilean female population. A prospective histological mapping of cholecystectomy pieces allowed the detection of 37 tumors not evident to the surgeon. Tumoral invasion engaged the mucous membrane in 7, the muscular layer in 8, the subserous layer in 12, the serous membrane in 5 and the surrounding adipose tissue of the gallbladder in 5 cases. 18 pts were reoperated on for resective oncological surgery. In 5 of these cases the ganglia, and in 6 the hepatic tissue behind the gallbladder were involved. Actuarial survival at 38 months was 48% (10 pts have died by the time of this publication). The prognosis of the disease was directly related to histological differentiation and to the degree of tumoral invasion. Gallbladder cancer has a poor prognosis even if the surgeon has no suspicion of the disease and a simple cholecystectomy is by no means a healing therapy.

Adult↗
PubMed1991

[Lithiasis of gallbladder in the IX region. Study of the autopsies in a zone with a high proportion of Mapuche population].

The frequency of gallbladder stones in he IXth Region of Chile with a large indigenous population, was studied in forensic necropsies from 1980 to 1989. Among 2,505 autopsies, 85% were males and 15% females. At least 1 "mapuche" surname occurred in 27% of cases. Stones were found in 34% of females and 12.7% of males. No differences were found between "mapuche" and non mapuche cases. Cholecystectomy had been performed in 2.3% of males and 9.1% of males. These results do not differ from those reported from other regions in Chile.

Adolescent↗
PubMed1990

Operative findings in patients with early forms of gallbladder cancer.

Of 52 patients diagnosed as having gallbladder cancer in a 2-year period, 15 had no evidence of serosal involvement. Four of these 15 patients had tumour confined to the mucosa and did not undergo reoperation while 11 patients underwent lymph node dissection and hepatic wedge resection at a second operation. The correct diagnosis was suspected before the first operation in only one of 11 patients undergoing reoperation; the tumour was found microscopically in seven patients. Of the 11 patients who underwent reoperation, five had lymph node involvement, and three of these patients had both liver and lymphatic involvement. Our results underline the difficulty of establishing the diagnosis of gallbladder cancer before operation and the lack of major morbidity and mortality suggests that there may be value in reoperating on patients found to have gallbladder carcinoma without serosal involvement. Further follow-up is required to assess the long-term value of this approach.

Adult↗
PubMed1990

[In situ and invasive cancer of the gallbladder: nucleolar organizer regions].

We studied samples from gallbladders of 10 subjects with invasive and 10 with in situ carcinoma of this organ. The number of nucleolar organizer regions, as revealed by colloidal silver staining, was at least 4 times larger in cancer samples than in control ones. Mean number of nucleolar organizer regions for invasive lesions was higher than for in situ ones (11.6 +/- 2.3 vs 9.4 +/- 1.3, p less than 0.04). The study of cellular markers may be helpful in establishing the preneoplastic nature of gallbladder lesions.

Adenocarcinoma↗
PubMed1990

[Neoplasms of Vater's papilla: study of nucleolar organizer regions].

We analyzed the number and aspect of nucleolar organizer regions in 11 specimens from ampullary carcinoma, by means of silver colloidal staining. The number of regions was higher than that found in intestinal villi but similar to that in cripti. The size of the regions was larger than any of those mentioned above. These elements may contribute to evaluate endoscopic samples in the diagnosis of ampullary lesions.

Adult↗
PubMed1990

[Association of gallbladder and Vater's ampulla neoplasms. Report of a case].

A 54 year old female was operated on for ampullary carcinoma diagnosed by retrograde cholangiography. Histologic study of the gallbladder resected at operation revealed another carcinoma at that location. Pancreato-duodenectomy plus a double segmental resection of liver was performed. The patient remains in good condition 11 months after operation.

Adenocarcinoma↗
PubMed1990

[Gallbladder cancer: anatomic and anatomo-pathologic considerations].

Gallbladder cancer is a common neoplasia in Chile. Subclinical forms constitute 30 to 50% of all cases and poorly differentiated lesions are more common in Chile than elsewhere. Traditional grading of this neoplasia according to the degree of wall infiltration neglects important aspects such as the discontinuity of the muscular layer, heterogeneity of the subserosa, microinvasion of the mucosa and Rokitansky-Aschoff sinuses. All of these factors may influence prognosis. Surgical biopsy of liver and lymph nodes in cases without infiltration of the mucosa has revealed up to 60% rate of hepatic infiltration and a somewhat lower on for lymph nodes. We have designed a study that will evaluate the importance of all these factors in the prognosis of gallbladder cancer in our institution.

Adenocarcinoma↗
PubMed1989

[Nucleolar organizer regions in gastric cancer].

Nucleolar organizer regions may be observed by colloidal silver stains. A considerable increase in the number of regions may be observed in tumors and other pathologic processes as an index of cellular proliferation. Among 20 studies in patients with gastric carcinoma we found a significantly greater number of nucleolar organizer regions in well differentiated tumors as opposed to less differentiated ones. No difference was found in nucleolar organizer regions between seal ring cell tumors and adenocarcinoma.

Adenocarcinoma↗
PubMed1989

[The sea blue histiocyte syndrome: a case report].

A young pregnant woman presented with splenomegaly and a hemorrhagic syndrome. A persistent alteration of several coagulation tests was demonstrated. Large foamy pigmented macrophages were shown by bone marrow aspiration. The histopathologic findings are consistent with the sea blue histiocyte syndrome, a benign type of lipid storage disease.

Adult↗
PubMed1989

[Gastric cancer in the IX Region of Chile: an analysis of 233 cases].

Gastric cancer is the leading cause of mortality from malignancy in Chile. Different reports indicate a high incidence of well differentiated forms of this tumor. Among 233 endoscopically diagnosed lesions in patients from the Ninth Region of Chile, we found a high incidence of poorly differentiated tumors and a relatively high incidence of signet-ring cell carcinoma. The incidence of inoperable lesions was high.

Adult↗
PubMed1989

[Gallbladder pathology in Temuco, IX Region].

We reviewed the histological (light microscopy) findings in 1553 biopsies obtained after surgery for gallbladder disease and correlated these with demographic characteristics of patients. Cancer of the gallbladder was present in 6.1%. Women prevailed in all age and disease groups, especially in mapuches (11:1). Both for neoplastic and nonneoplastic disease the proportion of patients with mapuche surnames was lower than expected for the population in the area. 52% of neoplastic lesions were not macroscopically apparent. Seven tumors involved only the mucous layer and 2 were intraepithelial. Only 2 tumors were well differentiated. The liver was the organ most frequently invaded by gallbladder cancer.

Adolescent↗
PubMed1989

[Study and application of the DNA pattern in oncology].

Abnormalities of DNA content are commonly observed in malignant tumors. Clinically relevant information may be obtained given the ease with which DNA pattern can be studied. Flux cytometry and photocytometry are the methods commonly used and both measure the emission of fluorescence after staining the nucleus. ADN pattern has been found to be related to prognosis in many tumors. Also, precancerous lesions and tumor heterogeneity can be analyzed by this technique.

Aneuploidy↗
PubMedDate not supplied

Gallbladder cancer in a high risk area: morphological features and spread patterns.

BACKGROUND/AIMS: Gallbladder carcinoma is one of the most frequent malignant tumors in Chile. The aim of this paper is to show our experiences in gallbladder carcinoma. METHODOLOGY: Six-hundred-sixty-nine cases of gallbladder carcinoma were included in this prospective study; 557 females (83.5%) and 112 males (16.5%). In 466 cases (70%), diagnosis was carried out in the cholecystectomy sample, 45 cases were partial cholecystectomies and 158 cases were metastases of gallbladder carcinoma. RESULTS: Ninety-eight per cent of the cases were adenocarcinomas, and in 85% of the cases gallstones were observed. Thirty-seven per cent of the primary tumors were macroscopically inapparent. One-hundred-thirty-one cases (29%) were early carcinomas and 323 cases (71%) were advanced carcinomas. A relationship between differentiation grade and infiltration level (p=0.0001) was observed. Lymph-node metastasis was found in 18.5%, 4.5% and 3.3% in the first, second and third lymph-node barriers respectively. Muscular tumors presented no lymph-node metastasis, while in serosal tumors lymph node metastasis reached 62% (p=0.04). Hepatic tumor infiltration was observed in 11%, 19% and 38% of muscular, subserosal and serosal tumors. CONCLUSIONS: The high frequency of inapparent carcinomas, gallstones and inflammatory changes of the vesicular wall are elements that make the pre-operative diagnosis of gallbladder carcinoma difficult. Differentiation grade and infiltration level are the most reliable prognostic factors in gallbladder carcinoma. Lymph-node metastasis or liver tumor infiltration are infrequent in early gallbladder carcinoma.

Adenocarcinoma↗
PubMedDate not supplied

[Malignant histiocytosis in children].

A case of malignant histiocytosis in a two year old boy is reported. His main clinical features were fever, lymphadenopathy, hepatomegaly and splenomegaly. Lymph node biopsy showed a sinusoidal type of lymph node infiltration, histiocytes of malignant aspect and erythrophagocytosis. Liver infiltration with tumoral cells was demonstrated by needle biopsy. The clinical evolution was rapidly progressive and after six months of chemotherapy he died of intercurrent respiratory infection.

Child, Preschool↗