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Biomedical subjects

J C Ballantyne

Publications and source records attributed to J C Ballantyne.

6 recordsLinked to original sources
PubMed1989

Pituitary-adrenal stress response in the absence of brain-pituitary connections.

To examine whether an acute pituitary-adrenal response to stress may occur in vivo in the absence of hypothalamic-pituitary connections, we measured plasma beta-endorphin (beta-EP) and corticosterone (C) in rats after acute thermal injury. beta-EP rose significantly after thermal injury in normal rats and rats bearing pituitary-to-kidney autotransplants but not in animals with pituitary aspiration without reimplantation. Corticosterone responses paralleled beta-EP but were significant only in normal controls. Propranolol pretreatment did not reduce postburn beta-EP and C rises in autotransplanted animals. Therefore, since circulating factors contribute in vivo to pituitary-adrenal responses, the widespread practice of using "stress hormone" responses to quantitate perioperative stress or pain may in some circumstances be flawed.

Animals↗
PubMed1977

Practolol and deafness.

Practolol ('Eraldin') is a beta-blocking agent whose prolonged use may result in the appearance of untoward side-effects, notably ocular symptoms, skin rashes and deafness. We report ten cases of deafness due, or thought to be due, to practolol; and in all except three of the cases (8,9 and 10), the deafness became manifest many months after the appearance of lesions in the skin and eyes. Progression of any hearing loss caused by this drug seems to be arrested by its withdrawal. Otologists are urged to report any suspicious cases to the Committee on Safety of Medicines, Finsbury Square House, 33/37A Finsbury Square, London EC2A IPP.

Aged↗