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Biomedical subjects

J C Bazin

Publications and source records attributed to J C Bazin.

At least 19 recordsLinked to original sources
PubMed1994

Peroxidation of model lipoprotein solutions sensitized by photoreduction of ferritin by 365 nm radiation.

A mechanistic study involving the 365 nm irradiation of aerated, phosphate-buffered solutions of human high-density lipoproteins (HDL3 fraction) and ferritin was undertaken. The 365 nm irradiation of phosphate-buffered horse spleen ferritin solutions induces the release of Fe2+ in the medium. The initial quantum yield of Fe2+ release on irradiation is 0.002. This quantum yield is oxygen independent. The 365 nm irradiation of mixtures of HDL and ferritin leads to alterations in apolipoproteins as revealed by tryptophan (Trp) oxidation and electrophoretic pattern modification. In parallel with protein damage, lipid peroxidation is induced as shown by hydroperoxide and thiobarbituric acid reactive substances (TBARS) formation. These peroxidations are strongly reduced in 0.1 M formate solution, which suggests chain initiation by .OH radicals or subsequent radicals produced by .OH. They are completely inhibited by desferrioxamine, consistent with propagation by Fe2+ ion. By contrast incubation of HDL in the presence of ferritin and FeSO4 induces only poor auto-oxidation. The biological relevance of this study is discussed.

Animals↗
PubMed1980

[Fungal intertrigo and lymphangitis (author's transl)].

The pathogenic agents are normal parasites of the epidermis but which may cause local signs and microbial secondary infection. Two types of fungus are distinguished: -- dermatophytes, which develop in the 4th interdigital space and may become exacerbated. -- yeasts, which develop from the digestive and genital mucosal surfaces. Laboratory diagnosis must be as precise as possible. Treatment consists of aeration, drying of skinfolds, alkalinization for yeasts, antiseptics and antifungal agents. Such fungal infections may represent the starting point of lymphangitis and erysipelas.

Antifungal Agents↗
PubMed1979

[Breast cancer: a dynamic approach of cellular immunity and immunostimulation with an immunoadjuvant: P40 fraction. (author's transl)].

The study of the immune status of breast cancer patients with delayed hypersensitivity skin tests reveals a clear immune deficiency in comparison with a reference patients group. This immunstatus was significantly improved by an immunstimulation with the P40 fraction. The responsive capacity to an immunstimulation appears independant of the lymphnodes involvment, whereas, on the contrary, the initial degree of immune deficiency appears connected. The P40 fraction has an immunstimulant effect comparable with the BCG and has not occasioned any local or general undesirable reaction.

Adjuvants, Immunologic↗
PubMedDate not supplied

An experimental and clinical study of immunocompetence and immunostimulation in breast cancer.

Two hundred and seven patients aged from 37 to 65 years with noninflammatory breast cancer treated by surgery without radiation were studied over a ten year period with a view to forecasting the prognosis on the basis of the immune status and treatment. The immunocompetence or immune status was studied in 121 patients by in vitro and in vivo pre and post-surgical skin tests. The immunostimulation or restoration of the immune status was conducted by the P 40 immunomodulator from the Pasteur Institute: in an experimental study whose results are based on modified Huggins model and take in to account the survival rate and the evaluation of tumor growth; in a subgroup of 86 patients, demonstrating that immunostimulation is effective in low-scores, improves tolerance to chemotherapy and increases the six year survival rate in high risk low-score patients. The results are encouraging enough to propose improving the survival rate in a prospective clinical study of early breast cancer treated by local and regional means using a protocol incorporating an immunostimulation based on the existing immunocompetence with interferon-induced reconversion of the target cells in the hope of specific stimulation.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Microcirculation and hyperkeratosis. Pathogenetic hypothesis and treatment].

The orthokeratotic thickening of the epidermis would appear to follow the deceleration or permanent interruptions of the cutaneous microcirculation. This explains the development of calluses, corns and warts in areas where the skin is compressed between bone and a hard external support. Peripheral vasometric anomalies give rise to the same thing. Pentoxifylline, restoring the capillary microcirculation, has a clearly curative effect.

Humans↗