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Biomedical subjects

J C Bode

Publications and source records attributed to J C Bode.

At least 163 records · Page 9Linked to original sources
PubMed1977

[Therapy of chronic hepatitis (author's transl)].

Therapy of chronic hepatitis as practized today is discussed, including general therapeutic procedures, the so-called "liver-protective substances", and drug therapy of chronic aggressive hepatitis and of liver cirrhosis. A causal treatment of chronic hepatitis is unknown; prognosis however can be improved by treatment with glucocorticoids as demonstrated by controlled clinical trials. A combination with azathioprin does have similarly good results with a decreased frequency of the unwanted side effects of the 2 drugs. The effects of other immunosuppressive drugs and of D-penicillamin cannot yet be evaluated sufficiently at present.

Anabolic Agents↗
PubMed1976

[Liver damage in chronic alcoholics with and without delirium tremens (author's transl)].

371 males admitted to a special hospital for withdrawal treatment of alcoholics were investigated on admission and repeatedly controlled during a follow-up of 3-6 months. In only 15% of all patients without delirium tremens there were no signs of liver disease on admission. 62% showed evidence of moderate or severe liver disease. 2-6 months after admission the percentage with moderate or severe liver disease had decreased (26%) while normal findings were obtained in 49%. On admission no correlation between frequency or degree of liver damage and the duration of alcohol abuse or daily intake of alcohol was demonstrated. Following abstinence of 2 months or more incidence of severe liver changes was nearly unchanged (16%) in patients drinking for more than 20 years, while it dropped distinctly in the groups with shorter duration of abuse (abuse less than 10 years: 5%). Histological alterations were distinctly more frequent in patients with abuse of more than 15 years (pronounced fibrosis 26%, cirrhosis 20%), as compared to alcoholics who drank less than 15 years (5 and 9%, respectively). In the patients with delirium tremens signs of severe liver disease were more frequent than in those without delirium. The trend towards normalisation of liver function tests was less in the former than in the latter (marked pathological findings following 2 months of alcohol abstinence in alcoholics with delirium tremens: duration of alcoholism less than 10 years: 16%; 11-20 years: 33%).

Adolescent↗
PubMed1976

[Treatment of acute viral hepatitis with laevulose infusions (author's transl)].

Until 1962 all patients with acute viral hepatitis admitted to the Medical University Clinic at Marburg were treated with laevulose infusions. This treatment was discontinued in 1963. Follow-up examination of 109 patients with acute hepatitis who had been given laevulose infusions and 91 who had not (both groups being similar as to age and sex and average severity of the disease) revealed that there was no significant difference between the two groups with regard to the fall in transaminase levels during the first seven weeks after the onset of jaundice. Serum-bilirubin concentration was also similar. On the other hand, the abrupt fall in serum-bilirubin concentration in the second to third week of illness, so typical of the spontaneous course, occurred a week later in those who had been given laevulose infusions. Duration of the disease until normalization of transaminase and serum-bilirubin concentration was not favourably influenced by laevulose infusions. It is concluded that such infusions do not have a favourable effect on the course of acute viral hepatitis.

Acute Disease↗
PubMed1976

[Clinic and therapy of acute pancreatitis (author's transl)].

A review of acute pancreatitis is given including epidemiology, etiology, clinical symptomatology, laboratory and X-ray procedures, clinical course, complications and prognosis of this disease. Therapy is discussed in extent; all therapeutical approaches are reviewed with special emphasis on effectiveness as evidenced by experimental and controlled or uncontrolled clinical studies of the therapeutic measure in question. An account is also given of the results of surgery in cases of hemorrhagic necrotizing pancreatitis. The following conclusions are drawn: Treatment of pain and early intensive treatment of complications are effective and essential in acute pancreatitis. Clinical experience does show in addition, that fasting acts upon the clinical course favorably. All other therapeutic approaches recommended up to now have not yet been proven to be effective.

Acute Disease↗
PubMed1975

[Inhibition of ethanol exidation on prolonged fasting in man: reversibility on fructose infusion(author's transl)].

Fasting for over 36 hours was found to inhibit ethanol metabolism in healthy volunteers by 43% (P less than 0.01) compared with values obtained after 12 hours' fasting. Ethanol oxidation was not inhibited by prolonged fasting when it was stimulated by intravenous fructose. The explanation for this effect is thought to lie in the inhibition of alcohol oxidation mainly by limiting the rate of NADH-reoxidation in the liver.

Alcohol Oxidoreductases↗
PubMed1975

[Enzyme levels and morphological picture of normal and cirrhotic rat livers following portal vein ligation and subcutaneous transposition of the spleen].

The effect of portal vein ligation after subcutaneous transposition of the spleen is investigated on enzyme-activities. and morphological pattern of the normal and cirrhotic rat-liver. The increase of glycolytic enzyme-activities and the decrease of enzyme-activities of oxidative metabolic pathways can be explained by adaptation on throttled blood supply of the liver. Significant decrease of arginase-activity (urea-cycle) can not be explained by reduced protein content of food (pair-fed-animals). Diminished substrate (ammonia)-level (NH3/t/hepatocytes) may be an explanation. Histological pattern of normal and cirrhotic rat liver is nearly unchanged after portal vein ligation.

Animals↗