PubMed Health⌕ Search

Biomedical subjects

J C Briggs

Publications and source records attributed to J C Briggs.

At least 19 recordsLinked to original sources
PubMed1992

Synthesis of diacylglycerol analogues as potential second-messenger antagonists and inhibitors of protein kinase C.

A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC). The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol. Compound 24 was the most effective inhibitor of the growth of MR4 and HT29 cells in culture, and 26 was more effective than 24 against HL60 cells.

Animals↗
PubMed1991

Effect of initial biopsy procedure on prognosis in Stage 1 invasive cutaneous malignant melanoma: review of 1086 patients.

After treatment for primary clinical Stage 1 invasive cutaneous malignant melanoma, 1086 patients were followed for a minimum of 5 years from initial operation. Patient data were retrieved from the unit's melanoma registry; 96 (8.8 per cent) were treated initially by incisional biopsy, 292 (26.9 per cent) by narrow margin excision biopsy and 698 (64.3 per cent) by wide margin excision. Logistic regression analysis was performed to assess the statistical significance of the association between the various factors. The method of initial biopsy was related to maximal tumour thickness, age, and sex. Incisional biopsy rendered 38 out of 96 (40 per cent) lesions not fully assessable on current histopathological criteria, significantly higher than for the other biopsy techniques (P less than 0.0001). Incisional biopsy did not adversely affect prognosis in terms of local recurrence and mortality. Prognosis was related to tumour thickness, age and sex of the patient, and not to biopsy technique. We recommend that all suspicious lesions should be submitted to excisional rather than incisional biopsy to avoid compromising the histological assessment, given the importance of maximal tumour thickness in determining treatment and prognosis.

Adolescent↗
PubMed1991

The vascularity of cutaneous melanoma: a quantitative histological study of lesions 0.85-1.25 mm in thickness.

The vascularity of 107 primary cutaneous melanomas has been characterized by morphometric histological analysis. The lesions selected for study were of thickness 0.85-1.25 mm and the aim was to evaluate the prognostic significance of tumour vascularity. Two groups of patients were identified; 86 with no evidence of recurrence after a minimum follow-up period of 5 years and 21 with locoregional recurrence and/or metastasis. The lectin Ulex europaeus type I was used for endothelial cell staining of tissue sections and morphometric analysis was performed to derive the vascular length, surface and volume density from independent measurements of tumour, adjacent dermis and the junctional zone between tumour and underlying tissue. A wide range of values was obtained for each parameter with increased vascularity always found at the tumour base compared with the tumour as a whole. In relation to the adjacent normal dermis, vascularity was generally found to be higher at the tumour base but either higher or lower in the tumour overall. Tumour recurrence could not be predicted by any of the derived vascular parameters either independently or together with other histological and clinical features. This study suggests that tumour vascularity is of no prognostic significance in melanoma of the above thickness range. The highly variable extent of tumour vascularity was not correlated with other clinical or histological parameters, but may have implications for the delivery of pharmaceutical agents used for diagnosis or therapy.

Adult↗
PubMed1989

The incidence of late recurrence (greater than 10 years); an analysis of 536 consecutive cases of cutaneous melanoma.

The main purpose of this study was, using a computerised database, to try to establish possible prognostic features shown in patients who develop late recurrence, after 10 years, from a melanoma. The records of 536 patients diagnosed and treated for cutaneous melanoma over a 10-year period were examined and 5 patients were found to have developed a late recurrence. These patients were all female and included both pre- and post-menopausal cases at the time of initial diagnosis. In 4 out of the 5 cases the primary lesion had been situated upon an extremity. This study adds to the evidence that prognostic indicators can lead to a possible identification of high risk patients and that the level of patient awareness and education must be maintained throughout the period of follow-up.

Adult↗
PubMed1989

Melanoma and pregnancy: a long-term follow-up.

Treatment of the pregnant woman with melanoma is contentious. With the aid of a computerized melanoma register, in which pregnancy data can be recorded, 290 women with melanoma were reviewed (249 alive and 41 dead). Overall, 23 patients were pregnant at the time of diagnosis of melanoma, and another 23 became pregnant at some time after primary treatment of a melanoma. Pregnancy appears to have no significant influence on the survival of patients with melanoma, but it is recommended that pregnancy should be avoided for the first three years following excision of a melanoma.

Adult↗
PubMed1986

Incidence of locally metastatic ('recurrent') cutaneous malignant melanoma following conventional wide margin excisional surgery for invasive clinical stage I tumours: importance of maximal primary tumour thickness.

In a minimum 5-year follow-up study of 638 primary clinical Stage I invasive cutaneous malignant melanomas (excluding lentigo maligna melanomas) excised with conventional wide normal tissue margins, the incidence of local tumour metastasis was 48/638 (8 per cent). The incidence of locally metastatic tumours rose from 2 per cent for tumours less than 0.99 mm thick, to 14 per cent for tumours between 5 and 6 mm in thickness. The rate of local metastasis was significantly greater for tumours greater than 2.0 mm compared with tumours less than 2.0 mm thick (P less than 0.01). Despite the anatomical restrictions to wide resection margins in the head and neck, these areas had the lowest regional incidence for local tumour metastasis (2 per cent). Over the prolonged postoperative follow-up period (median 11 years) 67 per cent (32/48) of patients with locally metastatic disease died of disseminated malignant melanoma, compared with a 31 per cent mortality (180/590) for those without local disease metastasis. The term 'local recurrence' is unhelpful in our attempts to understand the pathology of malignant melanoma, and the term 'local metastasis' could replace it with benefit.

Biometry↗
PubMed1986

Cutaneous malignant melanoma in the young.

Cutaneous malignant melanoma in children and adolescents is rare. Of over 1600 patients documented in the Melanoma Registry at Frenchay Hospital from 1967 onwards, only 29 cases are recorded who were 21 years of age or younger. Of these, four patients were pre-pubertal (13 years or less) and none arose from a congenital "giant" naevus. Fifteen patients developed metastases, 10 of whom showed spread of tumour within 30 months of initial presentation. Eight of these patients with metastatic disease died, with a maximum survival of 61 months. Only seven patients, five of whom have metastatic disease, survive more than 10 years after first presentation; nine patients, one of whom has secondaries, survive for 5 years or less.

Adolescent↗
PubMed1985

Malignant melanoma, evaluation of clinical follow up by questionnaire survey.

A retrospective questionnaire study, by post, revealed that 69% of patients, still living following first tumour recurrence, had detected the recurrence themselves prior to routine clinic appointments. Nearly 90% developed their first recurrence in the first 5 years following primary surgical treatment. Not only could the length of routine clinic follow-up after primary melanoma treatment be shortened, but with further education of the patient and involvement of the general practitioner it seems likely that patients can be trusted to detect their own recurrences and seek appropriate advice.

Evaluation Studies as Topic↗
PubMed1985

Melanoma precursor lesions and borderline melanomas.

The histopathological interpretation of melanoma precursor and borderline lesions remains difficult. The natural history of naevi is reviewed and, in the light of this, current views on the histological sub-types of melanoma, precursor lesions and benign lesions which may mimic melanoma are presented. As the criteria for these lesions are now becoming defined they should be applicable by most histopathologists, even those who may see only occasional cases. Childhood and minimal deviation variants, however, are likely to remain problems even for the expert. Fortunately such lesions are uncommon.

Adolescent↗