Biomedical subjects
Publications and source records attributed to J C Chisholm.
A case of nephrotic syndrome occurring in an elderly woman who was being treated with quinidine is described. The nephrotic syndrome resolved completely after discontinuation of quinidine treatment. It is felt that the use of quinidine was causally related to the development of nephrotic syndrome in this patient. As far as could be determined, no such case has been described previously in the medical literature in English.
Mouse blastocysts, aged 0, 2, 6 and 12 h from the onset of cavitation, were examined by transmission (TEM) and scanning (SEM) electron microscopy. In TEM sections, trophectoderm cells (TE) differed morphologically from those of the inner cell mass (ICM) by their flattened shape, paler cytosol staining and polarized disposition of both junctional complexes (apicolateral) and intracellular secondary lysosomes (SL; basal). Throughout this period of development, cytoplasmic processes, characterized by abundant SLs, cover approximately 80% of the juxtacoelic face of the ICM. These processes are shown to be derived from the basal surface of TE cells intermediately placed between polar and mural regions. In SEM preparations of the juxtacoelic ICM surface, revealed by 'cracking open' blastocysts, the processes appear as tongue-shaped, centripetally oriented structures which terminate collectively at a central area on the ICM surface. The potential of cultured ICMs to generate TE was demonstrated following their immunosurgical isolation from blastocysts aged up to 12 h post cavitation and by examining the sequence of ultrastructural changes associated with TE generation by ICMs from 2 h blastocysts. In contrast, the juxtacoelic cells of similarly aged ICMs observed in situ in ultrasections of intact embryos showed little or no evidence of totipotency expression as judged by the absence of TE characteristics. Since TE expression within presumptive ICM cells is thought to be generated by an asymmetry of cell contacts (Johnson & Ziomek, 1983), we propose that the juxtacoelic TE processes, by providing a cellular cover to the ICM, function in suppressing the expression in situ of ICM totipotency.
A case of chronic vestibulitis presented as episodes of recurrent drop attacks that had been interpreted as recurrent syncopal episodes. The importance of distinguishing between syncope and drop attacks-a difficult task-is emphasized. This case stresses the need to include benign vestibulitis in the differential diagnosis of syncope and drop attacks.
This paper details the simultaneous occurrence of a severe leukemoid reaction, non-bacterial thrombotic endocarditis (NBTE) (marantic endocarditis), and a consumptive thrombocytopathy without signs of micro-angiopathic hemolysis on peripheral blood smear in a patient with terminal metastatic, undifferentiated, large cell bronchogenic carcinoma. The case is presented and the condition is discussed in detail.
An unusual case of eosinophilic gastroenteritis (EGE) is reported. Fewer than 150 cases of EGE have been reported in the world literature to date. This is the first case of this disease reported to have rectal involvement, and only the second case in which colonic involvement has been histologically documented. The addition of this case to those previously reported in the literature would suggest that EGE may involve any segment of the gastrointestinal tract.
A 37-year-old female presented with complaints of ageusia, dysosmia, fatigue, and toilet tissue pica. She was found to have hypozincemia and iron deficiency anemia. Her complaints quickly abated when treated with oral zinc and iron.
A case of acute hydralazine induced lupus syndrome is described. No case has previously been described in which a small daily dose and a small accumulation dose have evoked this syndrome in such a short period of time. A pertinent and selective review of this syndrome is presented. The need for awareness of this syndrome manifesting in a patient exposed to small doses of hydralazine for short periods of time is emphasized.
Mitral valve prolapse (MVP) associated with congenital bicuspid aortic valve (CBAV) is an uncommon finding. In a study of 257 black patients with MVP, the author identified eight patients with associated CBAV. This paper discusses the association of the two lesions in relation to etiologic and surgical implications.
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This report describes the first case of mitral valve prolapse associated with lentiginosis profusa.
Reported herein is a patient who developed symptoms of bilateral carpal tunnel syndrome following radioactive iodine induced hypothyroidism. A review of the literature is presented.
A case of hypergastrinemia, diarrhea, and relentless hypokalemia occurring in a middleaged, mildly hypertensive female is described. The presence of a gastrinoma was suggested by the additional findings of an inordinate degree of hypokalemia for the amount of thiazide used for the treatment of her hypertension; failure of her hypokalemia to correct itself with adequate doses of oral potassium that had previously corrected this problem; and amelioration of her symptoms and hypokalemia when she was treated with short-term oral potassium chloride and longterm cimetidine.
The present case report clearly establishes nitrofurantoin as a cause for erythema nodosum (EN), presenting with serum sickness-like symptoms, typical and atypical EN skin lesions, and pseudo-splinter hemorrhages in a patient with documented mitral valve prolapse.
Although myasthenia gravis (MG) is frequently mentioned in standard textbooks and journal articles as a rare cause for pulmonary hypertension and right heart failure, no case can actually be found in the literature. The case described in this report is the first documented case of chronically decompensated MG manifesting itself as pulmonary hypertension, severe right heart failure, and functional prolapse of both the mitral and tricuspid valves. Interestingly, no hepatic biochemical abnormalities were present in spite of significant congestive hepatomegaly.
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