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Biomedical subjects

J C Davin

Publications and source records attributed to J C Davin.

68 records · Page 4Linked to original sources
PubMed1983

Fc-receptor function in Henoch-Schönlein disease of childhood.

The Fc-receptor function of circulating monocytes (CM) and/or of splenic macrophages (SM) was followed in eight children presenting with rheumatoid purpura. The Fc-receptor of CM and/or of SM was decreased in all cases during the acute phase of the disease without any correlation with the plasma values of C3, C4, C3PA or immune complexes. When a clinical improvement occurred, a reversal of the Fc-receptor blockade was noted. In contrast, the Fc-receptor function remained abnormal in three children with persistent nephritis. The sequential measurement of Fc-receptor function may be of predictive value in rheumatoid purpura of childhood.

Antigen-Antibody Complex↗
PubMed1983

Fc-receptor function in minimal change nephrotic syndrome of childhood.

This study was undertaken to establish whether the Fc-receptor function of circulating monocytes (CM) and/or of splenic macrophages (SM) is modified during the course of minimal change nephrotic syndrome (MCNS) of childhood. The Fc-receptor function of SM was ascertained by measuring the spleen to liver uptake ratio 40 min after IV injection of heat-damaged autologous erythrocytes labeled with 99Tc, whereas the Fc-receptor function of CM was determined by a "rosetting" test. The Fc-receptor function was followed in six girls presenting with a MCNS and receiving no therapy at the time of testing. The Fc-receptor function of SM was decreased in five patients during an acute phase of MCNS. In four of these five patients, the Fc-receptor function of CM was also altered. No significant correlations were observed between the Fc-receptor blockade and the C3, C3d, C4, C3PA or immune complex-plasma levels. The Fc-receptor blockade was persistent in three girls during remission. A prior incubation of CM with trypsin did not completely reverse the Fc-receptor blockade. Further studies are now being pursued in order to determine whether this persisting abnormality is inherited and mainly observed in relapsing nephrotic syndrome.

Adolescent↗
PubMed1981

A case of congenital nephrotic syndrome.

This case of congenital nephrotic syndrome is not easy to classify. Treatment with usually effective doses of cyclophosphamide and prednisolone was unsuccessful, whereas a treatment with gammaglobulin was concomitant with a decrease in the frequency of infections, improvement of the nephrotic syndrome, growth, psychomotor development and bone maturation. Electron microscopy shows basal membrane abnormalities not yet described.

Humans↗
PubMed1979

[Renal osteodystrophy in two children : a comparison of the effects of 1 alpha-hydroxycholecalciferol (author's transl)].

Two children suffering from renal osteodystrophy were treated by 1 alpha hydroxycholecalciferol (1 alpha OHD3) 1 microgr. each day, for 18 months. In both the level alkaline phosphatase decreased at the same time as endogenous immunoreactive CT increased, iPTH did not change steadily, whereas plasma creatinine rise. As plasma calcium concentration did not increase, it is suggested that the increase in endogenous CT concentration is a part of the favourable response to the treatment by 1 alpha OHD3.

Alkaline Phosphatase↗
PubMedDate not supplied

Characteristics of peripheral and peritoneal white blood cells in children with chronic renal failure, dialyzed or not.

OBJECTIVE: To explore further the mechanisms leading to immune deficiency in chronic renal failure and the role of dialysis treatment in these mechanisms. DESIGN: Cross-sectional and longitudinal analysis. PATIENTS: We studied 39 children treated with peritoneal dialysis (PD), 23 children treated with hemodialysis (HD), 33 children not yet dialyzed [chronic renal failure (CRF)], and 27 healthy children. Peritoneal cells were also obtained from PD children for analysis. METHODS: White blood cells (WBCs) were isolated from blood and peritoneal dialysis effluent by centrifugation. The number of CD2+, CD4+, and CD8+ T cells, B cells, and natural killer cells were measured by flow cytometry. RESULTS: The total peripheral blood lymphocyte count was lower in PD children (2.6 x 10(9)/L), HD children (2.1 x 10(9)/L), and CRF children (2.0 x 10(9)/L) compared with healthy children (3.1 x 10(9)/L, p < 0.05). The B lymphocyte count was also lower in PD children (0.34 x 10(9)/L), HD children (0.22 x 10(9)/L), and CRF children (0.33 x 10(9)/L) compared with healthy children (0.52 x 10(9)/L, p < 0.01). Numbers of CD4+ T cells were not different, but numbers of CD8+ T cells were lower in PD children (0.56 x 10(9)/L), HD children (0.63 x 10(9)/L), and CRF children (0.53 x 10(9)/L) compared with healthy children (0.77 x 10(9)/L, p < 0.05). The count of natural killer cells was lower in PD children (0.21 x 10(9)/L), HD children (0.17 x 10(9)/L), and CRF children (0.18 x 10(9)/L) compared with healthy children (0.50 x 10(9)/L, p < 0.0001). The CD4/CD8 ratio of lymphocytes in peritoneal effluent was 0.8 versus 1.9 in peripheral blood (p < 0.001). The CD2/CD19 ratio was not different. The cell subsets remained stable during the first year of PD treatment. The CD2/CD19 ratio in peritoneal effluent was higher in children with a peritonitis incidence > or = 1 per year. CONCLUSIONS: The reduced numbers of B lymphocytes, CD8+ T cells, and natural killer cells found in CRF children, dialyzed or not, may favor the frequent occurrence of infections.

Child↗
PubMedDate not supplied

Skin manifestations in vasculitis and erythema nodosum.

Cutaneous lesions are frequent in medium-sized and small vessel systemic vasculitides. The classic cutaneous manifestation of vasculitis is palpable purpura; however the clinical manifestations greatly depend on the size of the vessels affected. They usually do not affect prognosis but relapsing or intractable forms have been described. When skin manifestations are only one of the clinical signs of vasculitis, treatment with corticosteroids and, when indicated, an immunosuppressant, is mandatory, which usually leads to the rapid disappearance of cutaneous lesions. Conversely, when skin lesions are isolated, the diagnosis can be more challenging, but initial treatment may be less aggressive, e.g., dapsone or colchicine, reserving corticosteroids only for those patients in whom the former are ineffective. Erythema nodosum (EN) is the most frequent septal panniculitis. In general it is characterized by the sudden eruption of one or more erythematous and tender nodules or plaques located mainly over the extensor sides of lower extremities. EN resolves with complete "restitutio ad integrum" of the skin in 3-6 weeks. Relapses are uncommon but in patients with idiophatic, streptococcal or EN associated with other upper respiratory tract infections they are more frequent. The main treatment of EN is that of the underlying associated conditions, if demonstrated. Aspirin and other NSAIDs in full doses are often sufficient.

Cryoglobulinemia↗