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Biomedical subjects

J C Demoulin

Publications and source records attributed to J C Demoulin.

At least 109 records · Page 6Linked to original sources
PubMed1979

Histopathologic correlates of left posterior fascicular block.

Thirteen hearts from subjects (10 male, 3 female; mean age 65 years) with left posterior fascicular block were studied. Left posterior fascicular block was associated with right bundle branch block in nine cases and alternated with left anterior fascicular block in three. In nine of the patients, the conduction disorders were observed during an episode of acute myocardial infarction. Of these nine patients, four showed interruptive lesions at the level of the posterior radiation of the left bundle or of the posterior portion of the main left bundle branch. Two were found to have severe alterations scattered throughout the left bundle branch system: One of them had alternating left anterior and left posterior fascicular block; and the other manifested complete heart block in the course of her illness. No interruptive changes of the posterior fibers were found in three cases in which the heart was obtained early after death. All 9 patients had severe coronary artery disease (six had triple vessel disease and three of the six had a left main coronary arterial stenosis or obstruction; two patients had double vessel disease). Among the four patients with chronic left posterior block, three were found to have heavy calcifications of the left side of the cardiac skeleton; the remaining one had diphtheritic myocarditis. All had major alterations of the left-sided conduction system that were consistently maximal at the level of the posterior fibers or posterior portion of the main left bundle branch. In two of these patients scattered lesions were found throughout the left bundle branch fibers; one had alternating left anterior and left posterior fascicular block and the other had complete heart block. In general, the alterations underlying left posterior fascicular block were less widely spread than in left anterior fascicular block; however, they were more severe and more proximally located.

Adult↗
PubMed1979

[Mural thromboses of the right heart. Clinico-pathological study].

39 instances of mural thrombosis of the right side of the heart were observed among 2000 cases of post-mortem examinations. The right atrium was the most frequent site of thrombosis; the right ventricle was involved in 8 cases. The relationships between right sided thrombosis and rhythm disturbances, myocardial or valvular disease, myocardial infarction, pulmonary disease, neoplasm, sepsis and disturbance of coagulation are discussed. The high incidence of pulmonary embolism and their relationship with thrombosis of the right side of the heart are emphasized.

Adult↗
PubMed1978

Histopathological correlates of sinoatrial disease.

Six hearts from patients suffering from rhythm disorders consistent with the diagnosis of sinoatrial disease were histologically examined. Four of the patients had shown a tachycardia-bradycardia syndrome, and the remaining two patients episodes of sinus arrest or sinoatrial block with a slow junctional escape rhythm. The rhythm disorders had occurred in the setting of chronic sinoatrial disease (3 cases), acute myocardial infarction (2 cases), and diphtheritic myocarditis (1 case). The abnormalities which were more consistently observed consisted of (1) total or subtotal destruction of the sinus node (6 cases); (2) total or subtotal destruction of the areas of nodal atrial continuity (5 cases); (3) inflammatory or degenerative changes of the nerves and ganglia surrounding the node (6 cases); (4) pathological changes in the atrial wall (5 cases). Chronic or acute lesions involving the AV node, the bundle of His, and its branches or their distal subdivisions were also found in all 6 hearts. The relationship between the observed pathological changes and the physiological disorders are discussed.

Adult↗
PubMed1978

[A case of diphtheric myocarditis, Anatomoclinical study with histology of the conduction system].

Presentation of a case of diphteric myocarditis. The histological examination of the conduction system can explain the rhythm disturbances in the present case with the EKG characteristics of the sick sinus syndrome and the intraventricular conduction disturbances. The anatomical lesions are variables in their topography and age, explaining the variability of the troubles of the rhythm during the first weeks of the disease. The fibrotic scars and the ageing changes of the conduction system are probably the reason for the late constitution of AV block and sick sinus syndrome, years after the acute episode.

Adult↗
PubMed1977

Two unusual cases of intra-atrial gap.

Two cases are described in which, during investigation of rhythm disturbances, it was shown that, by delivering atrial stimuli of increasing prematurity, a point was reached where the artificial stimulus failed to induce an atrial response. However, with even more premature stimulations, atrial responses were again observed. These observations are best explained by a gap phenomenon in which very early stimuli delivered during the effective refractory period of the atria were delayed long enough in the exit area around the pacing electrode to allow atrial recovery.

Arrhythmias, Cardiac↗
PubMed1976

[Anatomy of the conduction system in an unusual case of a heart ventricle with double inlet (straddling tricuspid valve)].

The histological study of the conduction system has been done in a case of "straddling tricuspid valve". The main anomalies observed were an AV node located more anteriorly but at the left of the posterior interventricular septum and an hypertrophic bifasicular right bundle branch with an unusual anterior radiation. These morphological features allow to discuss the embryology of the conduction system and of the interventricular septum in that congenital cardiopathy.

Female↗