Liver cell volume regulation: size matters.
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Adenosine Triphosphate↗
Biomedical subjects
J C Dunkelberg
Publications and source records attributed to J C Dunkelberg.
LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein.
We describe the molecular cloning and characterization of LZ-FYVE, a novel embryonic factor that possesses two leucine zipper motifs and a FYVE-finger domain. A partial clone of LZ-FYVE, encoding a functional leucine zipper domain, was initially isolated from a mouse embryo cDNA library by virtue of its interaction in the yeast two-hybrid system with the transcription factor ATF-2. The LZ-FYVE protein demonstrated mouse embryo-specific expression by Northern blot analysis and was detected as a nuclear protein at very restricted periods (12--14 days post-coitus) in specific tissues during embryogenesis. In particular, LZ-FYVE protein was notable in embryonic lung, cartilage, and otic capsule. Structural analysis of the deduced, full-length LZ-FYVE amino acid sequence revealed two N-terminal leucine zipper domains as well as a C-terminal FYVE-finger domain. The FYVE-finger domains specifically recognized phosphatidylinositol 3-phosphate and have been previously described only in cytoplasmic proteins involved in endosomal membrane fusion, vesicular trafficking, or organelle-specific targeting. While LZ-FYVE may have endosomal functions in the cytoplasm, because LZ-FYVE is present in the nucleus at early stages of embryonic development, it is likely that LZ-FYVE has a nuclear function.
Activating Transcription Factor 2↗
Idiopathic colonic varices: an unusual cause of massive lower gastrointestinal hemorrhage.
We report a patient with massive lower gastrointestinal bleeding, probably from extensive colonic varices. Despite lengthy investigation, the etiology of the colonic varices was not determined. There are numerous reports in the literature of bleeding from colonic varices attributed to portal hypertension from cirrhosis or venous obstruction. However, bleeding from colonic varices located in the entire colon without demonstrable cause have only rarely been reported.
Adult↗
Acute oliguric renal failure due to ibuprofen overdose.
We have described a patient who had acute oliguric renal failure after ingesting a single large overdose of ibuprofen. This patient had no predisposing underlying disease, and subsequently had complete resolution of renal failure.
Acute Kidney Injury↗