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Biomedical subjects

J C Ganz

Publications and source records attributed to J C Ganz.

23 records · Page 2Linked to original sources
PubMed1988

Analysis of the dynamics of experimental epidural bleeding in swine.

The effects on epidural bleeding of two major factors were studied in a swine model. These were detachment of the dura from the skull and an epidural arteriovenous shunt. Firstly the effect of differing degrees of detachment of dura was studied in the absence of a shunt. Secondly the effect of the shunt was examined with a constant degree of dural detachment. Increasing the degree of the detachment of the dural from the skull increased the rate and volume of bleeding. In addition the greater the degree of dural detachment from the skull the easier it was for further dura stripping to take place. The shunt reduced the epidural pressure and increased the bleeding pressure. Sometimes it reduced the force which, acting on the dura would strip more dura free, but never enough to preclude further dura stripping. Larger shunts were associated with a longer bleeding duration. It is concluded that the effects of dura detachment and the epidural shunt acting in concert can explain the delayed expansion of an epidural haematoma and are consistent with the known variability of clinical epidural haematomas.

Animals↗
PubMed1985

Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter trial of the Scandinavian Glioblastoma Study Group.

A prospective and randomized trial has been performed in order to evaluate combined modality therapy in patients with astrocytomas grade 3 and 4. Follow-up information is available on 244 patients. One half of the series received radiation therapy twice a week (40.00 Gy/5 weeks), the other half five times a week (50.00 Gy/5 weeks). Misonidazole 1.2 g/m2 was given orally to one half of the patients in the first radiation treatment group 3 1/2 to 4 hours before the treatment. The other half received placebo. The second radiation treatment group was also divided in two halves, one receiving 0.48 g/m2 misonidazole and the other placebo 3 1/2 to 4 hours before radiation. The randomization also included a subdivision of the material into eight groups of which four were given CCNU and four no chemotherapy, beginning 3 months after operation. The dose of CCNU was 120 mg/m2 body surface every 6 weeks. All eight treatment groups showed practically identical periods of median survival, and no statistically significant differences were observed with regard to performance status, side effects, or complications. Another dosage and timing of misonidazole administration in relation to the irradiation schedule, and a consideration of effects of concomitant drugs like dexamethasone and phenytoin are discussed.

Actuarial Analysis↗
PubMed1976

Histiocytosis X of the cauda equina.

Laminectomy, performed on a 46-year-old woman because of weakness and paresthesias of the lower limbs, showed multiple discrete yellow nodules on the nerve roots of the cauda equina. One of these lesions was excised and proved to be a granuloma consistent with the diagnosis of histiocytosis X.

Cauda Equina↗