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J C Garcia

Publications and source records attributed to J C Garcia.

At least 37 records · Page 2Linked to original sources
PubMed1989

Diagnosis of autoerythrocyte sensitization syndrome in the emergency department.

Autoerythrocyte sensitization syndrome is characterized by sudden and spontaneous painful bruising and swelling occurring in young female patients with psychiatric disorders. This syndrome may present with such severe swelling of involved areas that aspiration or excision may be needed to relieve pressure. The presentation of this condition in the emergency department must be differentiated from more common coagulopathies. Differentiation from the self-mutilation disorder, which often presents to the ED, can be difficult. Although the pathogenesis is uncertain, purpuric lesions are reproduced by injections of washed red cell erythrocyte stroma, suggesting an autoimmune etiology. We describe a patient with recurrent bruising diagnosed in the ED who responded with classic inflammation to autologous injection of red blood cells.

Adult↗
PubMed1989

Protein kinase-A and the effects of parathyroid hormone on phosphate uptake in opossum kidney cells.

Current evidence indicates that signal transduction after receptor binding of PTH involves the stimulation of adenylate cyclase as well as stimulation of phosphoinositide metabolism. Recent studies, showing that PTH alters phosphate transport in opossum kidney cells at concentrations which do not increase cAMP production and that activators of protein kinase-C also alter phosphate transport, have led to the suggestion that there is a dual mechanism for the regulation of phosphate transport by PTH, namely, protein kinase-C at physiological levels of PTH and cAMP at higher levels of PTH. The present studies were designed to evaluate the relationship between cAMP-dependent protein kinase (PK-A), a more sensitive indicator of alterations in cAMP metabolism than measurements of total cellular cAMP, and phosphate transport in opossum kidney cells, in response to bovine (b)PTH 1-34 and [Nle8,Nle18,Tyr34]bPTH 3-34 amide. While bPTH 1-34 markedly stimulated cAMP accumulation (half-maximal stimulation between 1 and 10 nM), PTH 3-34 analog did not. Phosphate transport was inhibited in a dose-dependent manner by bPTH 1-34, with half-maximal effect occurring between 0.1 and 1 nM. [Nle8,Nle18,Tyr34]bPTH 3-34 amide also altered phosphate transport, although this peptide was 3 orders of magnitude less potent than bPTH 1-34. PK-A activity increased in response to bPTH 1-34 and correlated closely with the effects of PTH on phosphate transport. [Nle8,Nle18,Tyr34]bPTH 3-34 amide, which did not appear to increase cAMP, also resulted in a significant increase in the activity of PK-A. Studies of inhibition of cAMP accumulation using 2',5'-dideoxyadenosine demonstrated that while this agent markedly inhibited the accumulation of cAMP in response to PTH, the effects of PTH on phosphate transport were not altered. However, in spite of the reduction in cAMP the activation of PK-A was similar to control. These data indicate that the effects of PTH peptides on phosphate transport are more closely related to changes in the activity of PK-A than to levels of total cAMP. Activation of PK-A in response to PTH is demonstrable at the lowest doses of PTH that alter phosphate transport.

Animals↗
PubMed1989

Influence of pertussis toxin on parathyroid hormone stimulated cyclic AMP production and phosphate transport in opossum kidney cells.

There is evidence that guanine nucleotide-sensitive (G) proteins intervene in the activation of adenylate cyclase by parathyroid hormone (PTH). Furthermore, recent studies suggest that G proteins may be involved in the activation by PTH of phospholipase C, with subsequent elevation of diacylglycerol, inositol trisphosphate, and intracellular calcium. Since G proteins may be involved in both transduction systems postulated to mediate the actions of PTH, the present studies were performed to evaluate the influence of pertussis toxin, which prevents receptor-mediated activation of G proteins, on the effects of PTH in opossum kidney (OK) cells. In OK cell membranes, pertussis toxin catalyzed the adenosine diphosphate (ADP) ribosylation of a protein with a molecular weight of 41 kd on SDS-PAGE. Cholera toxin catalyzed the ribosylation of two proteins of molecular weight 52 and 45 kd. Pretreatment of the cells with pertussis toxin abolished the labelling of this 41 kd protein, confirming the access of the toxin into the cells and the presence of pertussis toxin-sensitive substrates. The ribosylation of the cholera toxin substrates was unaffected by pertussis toxin pretreatment of the cells. Treatment of OK cells with pertussis toxin did not change the basal levels of cyclic AMP, but increased the levels of cyclic AMP in response to bPTH 1-34 from 355 +/- 17 to 449 +/- 20 pmoles cyclic AMP per 5 minutes per culture. These results were consistent with the inactivation of an inhibitory G protein. Furthermore, PTH-stimulated cyclic AMP generation was inhibited by norepinephrine from 362 +/- 10 to 228 +/- 18 pmole cyclic AMP per 5 minutes per culture.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenylate Cyclase Toxin↗
PubMed1989

[What is new in the diagnosis of appendicitis? Borborygmi in the cecal region].

The author analysed a homogeneous prospective series of 200 appendectomies. He studied the reliability of various elements in the diagnosis of appendicitis, including a new physical sign: borborygmi in the cecal region, an objective element on clinical examination which was present in 65% of cases. Its association with pain on rectal examination allowed a diagnostic certainty of 98% to be obtained.

Adolescent↗
PubMed1985

Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.

Doxorubicin has been reported to cause ventricular arrhythmias and sudden death in the first 24 hours after administration. The authors placed continuous electrocardiographic recording devices on 30 patients 24 hours before, during, and 24 hours after doxorubicin administration. Nine patients experienced arrhythmias before treatment; 12 patients had posttreatment ectopy. No patient had life-threatening arrhythmias before or after treatment. Of the nine patients with pretreatment ectopy, only one experienced an increase in severity. Conversely, six patients without ectopy before treatment had arrhythmias after doxorubicin administration. The authors were unable to determine predictive factors in patients with no pretreatment ectopy who developed posttreatment premature ventricular contractions. The authors conclude that antecedent ventricular ectopy exists in the oncologic population and that this is not worsened by first-dose exposure to doxorubicin.

Adult↗
PubMed1984

Cerebrovascular disease in children.

Cerebrovascular disease in children is more common than was once recognized. It is typically associated with an underlying anatomic anomaly or systemic disease. The most common underlying anomaly found with thrombotic or embolic stroke is congenital or acquired heart disease, while the most common predisposing factors to intracranial hemorrhage in children, other than trauma, are the leukemias and arteriovenous malformations. Many of the disorders associated with childhood stroke are treatable. Children tend to show more recovery after a stroke than adults do.

Brain↗
PubMed1983

[Foreign bodies in the biliary tract. I. Postoperative foreign bodies in the biliary tract. Review of the literature (71 cases) apropos of 4 personal cases].

Starting out from four cases which they personally treated, the authors have made a complete review of the literature concerning biliary foreign bodies, and list 92 cases, with the following breakdown - 71 operative residues, 15 ingested bodies and 6 penetrating bodies. They attempt to analyse the mechanics of the formation of lithiasis around post-operative residues and assess its real frequency. They come to the following conclusions: most of these cases can be avoided by careful cleaning before closure of the choledocotomy, by the use of good-quality, correctly cut T-tubes and drainage material, by cutting the cystic duct as short as possible, and by exclusive use of resorbable fine thread in the biliary tract and the cystic artery.

Adult↗
PubMed1983

[Foreign bodies in the biliary tract. II. Unusual foreign bodies in the biliary tract. Review of the literature].

The authors have collated 21 cases of unusual foreign bodies, other than parasites, in the biliary tract. The collection includes 6 penetrating bodies, 4 ingested by patients who had undergone previous bilio-digestive anastomosis or a sphincterotomy, and 11 foreign bodies ingested by patients who had never had previous surgical treatment. They consider that the real frequency is certainly greater than might be expected from a review of the literature. They discuss the different ways of penetrating the biliary tract and stress the interest of wide biliodigestive anastomosis and large Y loops, as recommended by Roux, to prevent lithiasis forming on food residue trapped at the level of the anastomosis or upstream.

Biliary Tract↗
PubMed1983

Papillary-cystic carcinoma of the pancreas.

Papillary-cystic carcinoma of the pancreas is an extremely rare tumor which occurs in young adults, may invade locally, but is late to metastasize. As opposed to adenocarcinoma of the pancreas, portal vein invasion should not be included as a criteria for nonresectability. In the absence of metastatic disease, pancreatectomy combined with portal vein resection, if invasion is present, may offer a good prognosis and comparatively long survival time.

Adult↗
PubMed1983

[Surgical treatment of pilonidal disease. A new simplified technic].

A simplified technique for treatment of pilonidal sinus has been employed in 25 patients during the last 3 years. Initial results have been very encouraging as there have been no recurrences up to the present time. Mean duration of hospitalization was 3 days, patients can get out of bed after 24 hours, and work can be resumed after 2 weeks, complete healing requiring one month.

Acute Disease↗
PubMed1981

Recurrent thrombotic deterioration in the Sturge-Weber syndrome.

Hemiparesis, homonymous hemianopia and intellectual impairment are common features of the Sturge-Weber syndrome. While cerebrovascular thromboses have been noted with the syndrome, the pattern of recurrent thrombotic episodes producing an apparently gradual loss of function is not widely appreciated. The most important implication of this concept is the possibility of developing new methods of treatment, such as antiplatelet agents.

Adolescent↗