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Biomedical subjects

J C Gasser

Publications and source records attributed to J C Gasser.

9 recordsLinked to original sources
PubMed1978

Anterior choroidal artery aneurysms: their anatomy and surgical significance.

The experience of the senior author was 16 anterior choroidal artery aneurysms is reviewed. The anatomic variations of the origin of the anterior choroidal artery are discussed, and the danger of sacrificing the artery in aneurysm surgery is stressed. The surgical procedure upon these aneurysms has frequently been difficult, requiring careful microdissection. This was due to variations of the origin of the aneurysm in respect to the artery and their frequent contiguity.

Adult↗
PubMed1977

Carotid-ophthalmic aneurysms: direct microsurgical approach.

A series of 30 carotid-ophthalmic aneurysms, some of them bilateral, is reported. All of them were treated by a direct surgical approach. There were 25 patients in this series, 23 female and two male. In some cases there were associated pituitary adenomas and other aneurysms. The anatomy, clinical manifestations, and surgical treatment are discussed. There were no deaths among these 25 patients. Twenty-two of these patients recovered completely.

Adenoma↗
PubMed1976

Tolerance to the respiratory effects of marijuana in man.

The respiratory depressant effect of marijuana was studied by means of carbon dioxide respiratory response curves in eight healthy male subjects participating in a study of the effects of a 90-day ad libitum intoxication to marijuana. Subjects were studied in the morning after refraining from marijuana use since the previous evening. Respiratory response curves were done before smoking and at 15, 30 and 60 minutes after smoking two 900-mg cigarettes containing 2.2% delta9-tetrahydrocannabinol. Studies were conducted 2 to 3, 5 to 6 and 8 to 9 weeks after onset of intoxication. There was a significant change from base-line controls, indicating respiratory depression following marijuana smoking. A significant change in the time-effect curve over these three study sessions, indicative of tolerance, was noted. The degree of pulse elevation also decreased over the three study sessions, but this decrease in effect was not statistically significant.

Cannabis↗
PubMed1975

Respiratory effects of lorazepam, pentobarbital, and pentazocine.

The respiratory effects of a new benzodiazepine, lorazepam, were compared to those of pentobarbital and pentazocine. Pentobarbital, 50 and 150 mg, produced respiratory depression, as did pentazocine, 30 mg intramuscularly. Lorazepam at 1.33 and 4 mg intramuscularly produced none.

Anti-Anxiety Agents↗
PubMed1975

Respiratory effects of nefopam.

A respiratory study has been done to compare the respiratory effects of a potent new analgesic, nefopam, to morphine. Morphine was a potent respiratory depressant at therapeutic dosage while nefopam was not.

Clinical Trials as Topic↗
PubMed1975

[The respiratory effect of doxapram and pentazocine and their interaction (author's transl)].

A 2X2 factorially designed study has been done to determine the respiratory effects of pentazocine and doxapram in terms of the minute ventilation end-expiratory PCO2 response curve. Pentazocine 30 mg intramuscularly produced marked respiratory depression. Doxapram 60 mg intramuscularly produced significant respiratory stimulation. When this dose of doxapram was given in combination with 30 mg pentazocine it produced significant reduction in the amount of respiratory depression induced by the narcotic. The statistical analysis did not show that there was anything to suggest this effect was more than additive.

Adult↗