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Biomedical subjects

J C Gerster

Publications and source records attributed to J C Gerster.

At least 163 records · Page 9Linked to original sources
PubMed1983

Capacity to solubilize immune complexes in sera and synovial fluids from patients with rheumatoid arthritis.

Fifty-six sera and 33 synovial fluids from rheumatoid arthritis patients were studied to evaluate their capacity to solubilize immune complexes. A decreased function was found in 65% of rheumatoid synovial fluids when compared with 13 osteoarthritis synovial fluids. The decrease of immune complex solubilization capacity correlated with the decrease of hemolytic activity of the alternative complement pathway (P less than 0.001) and inversely with the level of immune complexes (P less than 0.05). Synovial fluids with low and normal immune complex solubilization capacity were compared; the results confirmed a possible role of the synovial complement system in modulating the size and thus the diffusion and clearance of locally generated immune complexes.

Adult↗
PubMed1983

A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis.

The exocrine pancreatic function has been estimated using the N-benzoyl-L-Tyrosyl para-amino-benzoic acid test (NBT PABA test) and by measuring the trypsinemia by radio-immunoassay (RIA trypsinemia) in nonselected cases of Sjögren's syndrome (SS) and seropositive rheumatoid arthritis (RA) in comparison with normal controls. The NBT PABA test was pathological in 37,5% of SS and 35% of RA patients but in none of the controls. The RIA trypsinemia was found to be high in 6,2% of SS and 45% of RA patients. These findings suggest that exocrine pancreatic function is impaired in some SS and RA cases. However, this exocrine pancreatic defect was clinically silent in all patients.

4-Aminobenzoic Acid↗
PubMed1983

Bursitis and tenosynovitis caused by group G streptococci.

Two cases of extraarticular Group G streptococcal infection are reported: one patient suffered from tenosynovitis of the extensor digitorum communis tendons of a wrist and the other from a prepatellar bursitis. In both cases penicillin therapy rapidly cleared all signs of infection.

Adult↗
PubMed1982

[Visceral manifestations of rheumatoid polyarthritis].

The commonest extra-articular symptoms of rheumatoid arthritis include nodules, vasculitis, neuro-muscular involvement and keratoconjunctivitis sicca with dry mouth, characteristic of Sjögren's syndrome. However, laboratory tests demonstrate that there is a high percentage of pericarditis and involvement of the lungs, liver and pancreas, which are clinically silent. Personal statistics on extra-articular symptoms in 110 cases of classic rheumatoid arthritis are presented.

Aged↗
PubMed1982

[Monoarthritis caused by Mycobacterium intracellulare. Personal observation of 2 cases and review of the literature].

The authors report two cases of arthritis of a proximal interphalangeal articulation due to Mycobacterium (M) intracellulare. In both cases, an intra-articular corticosteroid injection, given for preexisting pain, was responsible for infection. Both diagnoses were based on results from cultures of biopsied tissue. Histological findings in one of the cases were non-specific, whereas tuberculoid granulomas were present in the other. Articular destruction had occurred in both patients at the time of diagnosis. M. intracellulare was sensitive to ethambutol in the first case, and to ethambutol and cycloserine in the second. The evolution of the disease could not be ascertained in one patient lost to follow-up. The second patient's course of disease was favorable after surgical excision and 10 months of tuberculostatic drugs. The study reviews the principal contributions of the literature.

Adult↗
PubMed1982

Olecranon bursitis related to calcium pyrophosphate dihydrate crystal deposition disease.

A case of olecranon bursitis in an 81-year-old patient is presented. Analysis of the bursal fluid revealed positive birefringent crystals; radiographs showed calcifications in the distal triceps tendon. A bursectomy was performed. X-ray diffraction analyses demonstrated calcium pyrophosphate dihydrate patterns in a subcutaneous "tophus" and in a specimen of the tendon. On histologic examination, there was a bursitis with positive birefringent crystals on the bursa's inner surface; histologic images of "chondrocalcinosis" were observed in and around the tendon. It is concluded that bursitis may be part of the extraarticular manifestations of calcium pyrophosphate dihydrate crystal deposition disease.

Aged↗
PubMed1982

Lytic lesions of the femoral neck in rheumatoid arthritis simulating pigmented villonodular synovitis or malignancy.

Large lytic lesions, relatively asymptomatic, involving the femoral neck and the base of the head are described in two patients suffering from a classical seropositive rheumatoid arthritis. Histological examination failed to reveal signs of malignancy, infection or pigmented villonodular synovitis. There were no rheumatoid nodules but a chronic hypertrophic villous synovitis was found. Rheumatoid synovium may invade the superior extremity of the femur; this fact is important in the differential diagnosis of destructive lesions of the femoral neck in RA.

Aged↗
PubMed1981

[Which anti-inflammatory agents should be used in rheumatology?].

The principles governing the use of anti-inflammatory drugs in rheumatology are reviewed. Non-steroidal anti-inflammatory drugs and corticosteroids, either systemic or local, have a transient effect. On the other hand, treatments with basic medications such as gold salts of D-penicillamine induce prolonged beneficial action. They are, however, useful chiefly in rheumatoid arthritis but not in ankylosing spondylitis or variants, nor in gout or osteoarthrosis. The side effects and contraindications are described and discussed.

Adrenal Cortex Hormones↗
PubMed1980

Carpal tunnel syndrome in chondrocalcinosis of the wrist. Clinical and histologic study.

Carpal tunnel syndrome (CTS) defined electromyographically was found in 8 of 22 unselected patients with chondrocalcinosis of the wrists (bilateral in 6, unilateral in 2). Thenar atrophy was the most frequently encountered clinical sign. In the hands with CTS, calcifications of the wrist were more extensive than in the hands, without CTS. Degenerative joint changes of the hands were significantly more frequent in the group suffering from CTS. Surgery was performed in 5 patients with CTS. Microscopic examination of the volar carpal ligament and the flexor synovial tendon sheath failed to reveal histologic signs of chondrocalcinosis. However, the presence of scarce crystals, as seen in polarized light as well as electron microscopy, suggests a minor form of chondrocalcinosis.

Adult↗
PubMed1980

Plantar fasciitis and Achilles tendinitis among 150 cases of seronegative spondarthritis.

A painful heel syndrome (plantar fasciitis and/or Achilles tendinitis) was found in 33 among 150 patients suffering from a seronegative spondarthritis. The clinical and radiological manifestations of this syndrome were similar in the nosological entities included in the seronegative spondarthritis group. HLA-B27 antigen was found in 91% of the patients, radiological sacroliitis in 64% and an asymmetric peripheral arthritis in all cases. By contrast, Achilles tendinitis was not encountered in 220 cases of rheumatoid arthritis; plantar fasciitis was exceptional in the same cases.

Achilles Tendon↗