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Biomedical subjects

J C Gilson

Publications and source records attributed to J C Gilson.

At least 19 recordsLinked to original sources

International classification trial of AIA set of 100 radiographs of asbestos workers.

A series of 100 full size radiographs illustrating the range of asbestos related radiographic changes was collected by the Asbestos International Association to provide a demonstration and teaching supplement to the ILO 1980 International Classification of the Radiographic Appearances of Pneumoconioses. Each film was read by 12 experienced readers from ten countries; the readings have been summarised by a median reading, with the range covered by two thirds of the readers. The occupational histories and some relevant clinical information are also available. It is proposed that, in the use of this set, readers should classify each film using the ILO classification rules, particularly without reference to the summary reading or the additional information. Comparing the individual readings by the 12 readers, most of the variation in reading the profusion of small opacities was ascribable only to random variation, with little consistent bias between readers. By contrast, two readers recorded pleural changes much more frequently than their colleagues. This illustrated a major problem with the ILO 1980 Classification. Several others which occurred in this reading trial are also discussed.

Asbestos

Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel.

One hundred and fifty five male cases of asbestosis certified by the London Pneumoconiosis Medical Panel during 1968-74 were followed up during 1978-9, 4-11 (mean 7.5) years after certification. Fifty nine patients had died, 23 (39%) from lung cancer, 6 (10%) from mesothelioma, and 11 (19%) from other respiratory causes. The number of observed deaths was 2.25 times greater than expected and 7.4 times greater than expected for lung cancer. Adenocarcinoma was the commonest histological type but other cell types were also increased. Finger clubbing (p less than 0.01) and percentage of predicted FEV1 (p less than 0.01) were of value in predicting death, but increasing profusion of small opacities greater than 1/0 (ILO/U-C international classification of radiographs of pneumoconiosis, 1971), duration of exposure to asbestos, time from first exposure to asbestos, and percentage of predicted vital capacity and transfer factor did not predict death.

Adult

Significance of finger clubbing in asbestosis.

The prognostic significance of finger clubbing in asbestosis has been assessed in 167 cases certified by the London Pneumoconiosis Medical Panel from 1968 to 1974. Finger clubbing developed early in the clinical course of the disease and was associated with a lower gas transfer, a higher mortality and a greater likelihood of progression in intrapulmonary fibrosis than was found among cases without finger clubbing. Finger clubbing was not associated with heavier asbestos exposure. Its presence appears to be associated with a more severe form of disease.

Adult

Pleural calcification in northwest Greece.

Mass miniature radiography in 1969 detected a high prevalence of pleural calcification in three villages in northwest Greece. In 1980 a survey of a 15% sample of the population over the age of 10 was carried out with a 80% response rate. Full-size radiographs, ventilatory capacity measurements, and a detailed questionnaire on respiratory symptoms, type of work, and residence were used. Independent classification of the 408 films by two readers using the ILO/UC scheme showed very few small opacities but a very high prevalence of pleural calcification first evident in young adults and rising to 70% in the elderly. The overall prevalence was 34.7% in men and 21.5% in women. A comparison with the 1969 survey showed a progression rate of 5% per annum. In neither sex was there a significant relation of pleural calcification to smoking, ventilatory capacity, nor type of work, though those classified as field croppers had a slightly higher prevalence. There was no obvious evidence of increased lung cancer or mesothelioma in the villages. The agent responsible for this apparently benign condition was not identified.

Adolescent

Progression of asbestos radiographic abnormalities: relationships to estimates of dust exposure and annual decline in lung function.

The determinants of radiographic worsening were examined in a cohort of 244 asbestos-cement manufacturing workers. Progression of irregular small opacities was related to higher average and cumulative dust exposures. Progression of pleural thickening or pleural plaques was related to length of exposure and time since first exposure, but not to average or cumulative exposure. Larger declines in forced vital capacity and forced expiratory volume (one second) were related to larger cumulative dust exposures and to progression of irregular small opacities and pleural thickening. Progression of pleural calcification was not associated with significantly declines in lung function. Changes in lung diffusing capacity did not correlate with measures of dust exposure or with progression of radiographic abnormalities.

Adult

Asbestos cancers as an example of the problem of comparative risks.

Major differences in excess cancer risks have occurred in the asbestos industry in the past; part of this difference is probably related tp dustiness, part to the type of fibre used. In the case of mesotheliomas there is evidence of a major effect of the fibre type in the order of risk, crocidolite greater than amosite greater than chrysotile greater than anthophyllite. Differences of risk within an industry indicate that there is a dose response relation for both bronchial cancers and mesotheliomas. Also that in some instances it has been possible to identify lightly exposed groups in which no excess risks were detectable. As these least exposed groups are likely to have had several orders of magnitude heavier exposure than the general population, the risks to the general public are likely to be negligible. Bronchial cancers in absolute numbers are the major excess risk and are highly smoking-related. Stopping cigarette smoking is likely to be of paramount importance in reducing the excess cancer risks in asbestos-exposed individuals. Cancers in other sites which may possibly be related to asbestos exposure need further study even though the magnitude of the excess risk has been small compared to the lung cancers. In my view it is now possible to use the epidemiological evidence and experimental results to predict with fair confidence the physical and chemical characters and dose of natural and man-made fibres which will not cause a significant hazard in the future.

Accidents, Occupational

Chest symptoms in farming communities with special reference to farmer's lung.

Surveys were carried out on random samples of the farming population in Devon and Wales in order to estimate the prevalence of respiratory symptoms and of positive precipitin reactions to thermophilic fungi. Bronchitis, as defined, was common among the Welsh hill farmers, and the proportion of positive serological tests was higher in both the areas surveyed in Wales as compared with Devon. All three surveys confirmed a previous finding that the proportion of positive precipitin tests was higher among non-smokers than smokers. Although the numbers were small there was some indication that measurement of peak expiratory flow showed different relationships with age in non-smokers according to the presence or absence of positive precipitin tests. The difficulty of determining prevalence rates for farmer's lung is discussed, but the results suggest a rate not dissimilar to those found in two areas of Scotland which were more than 20 times higher than any figure previously reported in Britain.

Adolescent