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Biomedical subjects

J C Goes

Publications and source records attributed to J C Goes.

9 recordsLinked to original sources
PubMed2001

Sensitivity and specificity of BCG scar reading in Brazil.

In a cross sectional survey within a community trial of BCG efficacy evaluation in Brazil, trained teams inspected children's upper arms and obtained information on BCG vaccination from guardian letters and vaccination cards. Nurses re-examined the sub-sample of children blindly. High agreement was found between the two scar readings (Kappa = 0.839). High sensitivity and low specificity was observed when guardian or card information was the gold standard. Sensitivity remained high when guardian and card information agreed. When disagreement occurred, sensitivity remained high and specificity was very low. BCG scar is a good indicator of BCG vaccination.

BCG Vaccine↗
PubMed1998

Anionic collagen: polymer composites with improved dielectric and rheological properties.

This work describes the preparation and characterization of anionic collagen composites with rhamsan and vinylidene fluoride-trifluorethylene with improved rheological and dielectric properties without loss of collagen secondary structure with an interaction occurring between both macromolecules of the composites. On a comparative basis, the force needed for the extrusion of anionic collagen:rhamsan composites was in the range from 0.088 to 0.080 J compared to that for collagen of 0.189 J. Anionic collagen:vinylidene fluoride-trifluorethylene composites were characterized, in the case of the 1:1 composite, by a pyroelectric coefficient of 1.89 x 10(-4) cm(-2) K(-1), which was significantly higher than those determined under the same conditions for native anionic collagen and vinylidene fluoride-trifluorethylene.

Anesthetics↗
PubMed1987

Practical approaches to screening for cervical cancer.

The Program of the Fundação "Centro de Pesquisa de Oncologia" (FCPO) and the Instituto Brasileiro de Controle do Câncer (IBCC) in São Paulo has examined 980,977 women from 1970 to September 1985. Dysplasias, in situ, and invasive carcinomas were detected in 15,123 women (1.5%). The rates of false-negative and false-positive cytologic diagnoses of the program are 2.3% and 27%, respectively. The following epidemiological variables were evaluated: age, parity, age at first sexual intercourse, age at first pregnancy, education, and age at menarche. It was found that women at higher risk for cervical carcinoma in this population were those 26 years of age or older, with 4 or more pregnancies, women who had the first coitus before 18 years of age, and the first complete pregnancy before 19, as well as illiterate women or those who did not complete the first 4 years of primary school. In Brazil, the frequencies of cervical carcinomas are 25.8% for in situ and 72.2% for invasive (0.4 to 1). In this program, the corresponding percentages are 61.0% for in situ and 39.0% for invasive carcinomas (1.6 to 1). Including dysplasias, the percentages for Brazil are 56.3% for severe dysplasias plus in situ carcinomas and 43.7% for invasive carcinomas (1.3 to 1). In the FCPO/IBCC Program these percentages are 83.2% and 16.8% (5 to 1).

Adolescent↗
PubMed1986

Carcinoembryonic antigen. A possible predictor of recurrence in cystosarcoma phyllodes.

Tissue carcinoembryonic antigen (CEA) and cytosolic estrogen and progesterone receptors were studied in 15 patients with cystosarcoma phyllodes (CSP) aiming at predicting recurrence of the tumor. Polyclonal (rabbit, monospecific) and monoclonal (mouse) antibodies anti-CEA were applied to formalin-fixed, paraffin-embedded tissue sections using an indirect (PAP) immunoperoxidase method. Estrogen receptors (ER) and progesterone (PR) receptors were determined by a charcoal-dextran method. ER was detected in 4 of 15 primary CSP (mean level, 22 fmol/mg protein). CEA was demonstrated exclusively in the epithelial components of 12 of 15 tumors. Strong expression of CEA was verified in eight tumors, six of which recurred locally one or more times. None of the seven tumors negative or weakly reactive for CEA had recurrences. No correlation was found between expression of tissue CEA and steroid receptor status of the tumors. Our data indicate that strong CEA expression in CSP correlates with tumor recurrence.

Adult↗
PubMed1985

Elastosis and steroid receptors in primary breast cancer.

The association between the presence of both estrogen (ER) and progesterone (PR) receptors, and the grade of elastosis was evaluated in 100 primary breast carcinomas, 37% of which were from menopausal patients. ER levels were higher in post- than in premenopausal women but only when both ER and PR were present. Progesterone receptor levels were independent of menstrual status but the lowest PR positivity in premenopausal patients was observed during the late luteal phase. The extent of elastosis of the 100 tumors was: Grade 0 (absent), 24%; Grade 1 (small or moderate), 49%, and Grade 2 (marked), 27%. The extent of elastosis was not related to the patient's menstrual status. A significant association was observed between marked elastosis and the presence or absence of both ER and PR. No relationship was observed between the ER + PR and ER-PR+ subclasses and the extent of elastosis. Our data suggest that marked elastosis results from the presence of hormone-dependent cells in human breast carcinomas.

Adult↗