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Biomedical subjects

J C Gonçalves

Publications and source records attributed to J C Gonçalves.

12 recordsLinked to original sources
PubMed2005

Influence of diet on assimilation and turnover of 13C in the tissues of broiler chickens.

The 13C turnover rates of the liver and thoracic pectoral muscle of growing broilers were determined by feeding diets with varying 13C content. Male chicks (1-d-old) were subjected to treatments based on free choice of 5 different mixes of energy and protein sources from plants with C3 and C4 photosynthetic pathways that had differing 13C content. Rice bran (R) and soybean meal (S) were the C3 sources, while maize (C) and maize gluten meal (G) were the C4 sources. Choices were R + S, C + G, R + G, C + S or R + C + G + S. The 6th treatment was a complete feed (CF) that was similar to a commercial broiler feed. The isotopic composition of the birds' tissues was representative of the isotopic composition of the diets. The assimilation was faster for C3, in both liver and muscle, than for C4 diets, and give the delta per mil difference between the diet and tissues. The liver is the most active metabolic tissue and gave more rapid isotope turnover than in muscle.

Animal Feed↗
PubMed2004

Tracing metabolic routes of feed ingredients in tissues of broiler chickens using stable isotopes.

The present study aimed to quantify the proportion of 13C from energy and protein feed ingredients that follow the metabolic routing of the liver and muscle in broiler chickens. A stable isotope of carbon technique was used that is based on the isotopic discrimination that occurs in the plants during the photosynthesis process. One-day-old male chicks were subjected to treatments based on free choice of energy and protein sources. Rice bran (R) and soybean meal (S), C3 plants, have higher isotopic ratios than corn (C), a C4 plant, and corn gluten meal (G). Choices were R+S, C+G, R+G, C+S, or R+C+G+S. A complete feed (CF) was a sixth treatment. Feed intake and BW were measured at 30 d of age, when liver and breast muscle were collected for isotopic analysis. Treatments affected the amount of feed intake and the choices of energy or protein sources. Complete feed had the largest intake, differing from the other treatments that had free-choice feeding. Final BW was a direct reflection of consumption by these birds in all treatments. The isotopic results indicated that the 13C/12C ratio was generally higher in breast muscle than in liver, probably because of higher protein content. Moreover, in the liver, the proportion of 13C retained from the energy ingredient was greater than the proportion from the protein ingredient. That is in contrast to muscle, where the proportion of 13C retained from the protein ingredient was greater than from the energy ingredient that was self-selected.

Animals↗
PubMed1998

[Squamous cell carcinoma of the face: therapeutic approach].

Cutaneous squamous cell carcinoma is the most common metastatic skin cancer. The importance of early recognition and thorough treatment of premalignant lesions as well as the recognition of risk factors of the neoplasms that are most likely to metastasize must also be emphasized. A retrospective study of 126 patients, treated for primary squamous cell carcinoma of the face, was undertaken over a 7-year period. An attempt is made to define the major therapeutic modalities chosen, taking into consideration the specific anatomic location.

Adult↗
PubMed1997

Debulking of skin cancers with radio frequency before cryosurgery.

BACKGROUND: The purpose of prior debulking of skin cancers, by curettage, is to prepare the lesion for cryosurgical treatment. The main inconveniences of that procedure are the nearly always inevitable hemorrhage and the time necessary to control it. METHODS: We performed a study consisting of debulking skin tumors with radiosurgery, prior to cryosurgery, on a series of 38 patients (31 basal cell carcinomas, six squamous cell carcinomas, and one Bowen's disease), meeting the classical indications for cryotherapy. CONCLUSIONS: The advantages of the latter procedure over the traditional debulking by curettage are: the time needed to perform a biopsy, with easy and fast control of the bleeding, is considerably shortened; the whole procedure can be easily performed in one single session; the required surgical material also is greatly reduced; and the treatment can be performed on an out-patient regimen.

Aged↗
PubMed1997

Fractional cryosurgery. A new technique for basal cell carcinoma of the eyelids and periorbital area.

BACKGROUND: Cryosurgery is an established method to treat malignant tumors of the eyelids and periorbital area. Nevertheless, it has been abandoned for tumors greater than 10 mm, because it gives irregular esthetic results and, in some cases, lagophthalmos. OBJECTIVE: To devise a new method for the treatment of such tumors. METHOD: Fractional cryosurgery is performed in stages: the center of the lesion is frozen, resulting in a reduction of the tumor; this procedure is repeated, as necessary, until the lesion's diameter is smaller than 10 mm; the standard cryosurgical procedure is then carried out. RESULTS: The treatment of the first 20 basal cell carcinomas with diameters between 10 and 24 mm is described, with excellent clinical and cosmetic results. CONCLUSION: With fractional cryosurgery, the final scar bears no relation to the size of the original tumor but, instead, corresponds to the size of the lesion preceding the final cryosurgical procedure.

Aged↗
PubMed1994

The corpus cavernous electromyography in the erectile dysfunction diagnosis.

The single potential analysis of cavernous electric activity (CC-EMG), registration bands were studied in 144 patients with erectile dysfunction followed from November 1992 to March 1993. We attempted to correlate abnormal electromyographic records with reduction of the cavernous bodies and albuginea expansibility, as measured by cavernosometry/rigidometry. In this selected group of patients, with venous leak of different flow, the main associated causes of the erectile dysfunction were cavernous neuromyopathy (91), diabetes mellitus (20), disturbances of the arterial influx (7), endocrinological factors (4), Peyronie's disease (3). Some patients (15) presented with a penile bend. A history of alcohol and tobacco use was obtained: 38 patients smoked 15 to 60 cigarettes/day and 43 patients drank moderate to heavy. The coexistence of other pathologies, has been investigated, showed many other associated diseases. The study attempts to determine if some electromyographic standards in patients with erectile dysfunction, could, by themselves, be a formal indication to penile implant, for a PGE1 self-injection program or for use of a vacuum device. Our results suggest that at least in some cases CC-EMG studies may be clinically relevant and allow choice of optimal therapy.

Action Potentials↗
PubMedDate not supplied

Tolerable dietary lipid content that does not alter insulin secretion.

Lipids, either as membrane components or as fuel, are important nutrients that can affect insulin secretion. The aim of this study was to establish the maximum tolerable amount of fat present in the diet, which does not induce significant alteration in the process of insulin secretion. For that, just-weaned male albino rats (70-90 g body weight) were fed during 6 weeks with diets for growing rodents containing 7% fat (A Group) as recommended by the American Institute of Nutrition-AIN. Two other groups in which the fat content of the diet was increased to reach 10% (B Group) or 13% (C Group) were also included. Insulin release, 86Rb+ and 45Ca2+ Fractional Outflow Rate (FOR) during the process of glucose-induced insulin secretion was determined in perfused islets isolated from these animals. No statistical differences in these parameters were detected between A and B rats. However, in the C group, a lower 86Rb+ FOR was found during the whole experiment and a poor insulin secretory response to glucose stimulus was observed. These results led us to postulate that the maximal limiting amount of total lipids present in the diet that does not impair the process of glucose-induced insulin secretion is 10%. These findings authorize future studies on the interference of different dietary lipid sources, in a content 43% more elevated than that recommended (10% against 7%), on the mechanisms of insulin secretion.

Animals↗