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Biomedical subjects

J C Harbert

Publications and source records attributed to J C Harbert.

8 recordsLinked to original sources
PubMed1988

Scintigraphic evidence for relief of airways obstruction in cystic fibrosis.

A simple scheme for quantifying lung perfusion scintigrams was developed to evaluate the efficacy of a therapeutic regimen for the relief of airways obstruction in cystic fibrosis patients. Ten hospitalized patients were given conventional therapy including administration of intravenous antibiotics, mucolytic aerosols, chest physical therapy, and adequate nutrition and hydration as adjuncts to a single bronchoscopic bronchial washing procedure. Quantitative scoring of the lung scintigram was based upon the severity of the perfusion defects in equivalent upper and lower lung fields, as viewed from right and left posterior oblique projections. Seven to ten days following bronchoscopic washing, scintigraphic scores were found to correlate with changes in both the forced vital capacity and the one-second, time forced expiratory volume (r = 0.78, 0.70, respectively; P <.05). The severity of defective lung perfusion indicated the loss of lung volume and perfusion due to airways obstruction and secondary hypoxic vasoconstriction. Chest radiography was less reflective of improvement than lung scintigraphy. It was concluded that serial pulmonary perfusion scintigrams provide a sensitive tool for evaluating the relief of airways obstruction in cystic fibrosis.

Adolescent↗
PubMed1986

Hypertrophied thyroid tissue in a thyroglossal duct remnant.

A 37-year-old woman was evaluated for a neck mass. This was located in the midline below the hyoid bone. Thirty-three years had elapsed since she had undergone subtotal thyroidectomy for hyperthyroidism. Eight years prior to examination, the patient had discontinued her thyroid maintenance medications. She had discovered the mass eight months prior to examination. Thyroid scan (Fig. 1) showed intense uptake in the mass. At operation the mass was attached to the midportion of the hyoid bone by a small fibrous band, as is usual in a thyroglossal duct remnant. Biopsy results showed diffuse thyroid hyperplasia. Thyroglossal duct remnants are known to harbor cysts or thyroid carcinoma, but growths of compensatory hyperplastic tissue are unusual.

Adult↗
PubMed1985

Monoclonal antibodies in nuclear medicine.

Monoclonal antibodies have been a part of biomedical research for nearly a decade, yet a comparable period of time may be required before radiolabeled monoclonal antibodies come into standard practice in the diagnosis and therapy of human disease. Difficulties in identifying appropriate antigens, developing the optimal antibody species, attaching the most effective radiolabel and choosing the best method of administration all confound present investigations. The problems confronting therapeutic applications are, for the most part, an extension of those associated with diagnostic techniques. Still, there is much well-deserved optimism, and progress in all areas of investigation will ultimately come together to resolve most if not all of these problems. It is inevitable that monoclonal antibodies will have significant impact on the practice of nuclear medicine, and presented here is a review of the basic knowledge as well as an update on the current status of radiolabeled monoclonal antibodies in medicine.

Animals↗
PubMed1977

Computed cranial tomography and radionuclide cisternography in hydrocephalus.

Computerized Cranial Tomographic scanning has replaced radionuclide cisternography in screening both adult and pediatric patients for hydrocephalus. Nevertheless, cisternography provides indispensable information about the CSF clearance capacity and remains a valuable adjunct to the excellent anatomic detail provided by CCT scans. In patients without emergency symptoms, cisternography provides the best indication as to whether or not diversionary shunting is likely to relieve the patient's symptoms.

Adult↗
PubMed1977

Radionuclide techniques in the evaluation of cerebrospinal fluid shunts.

Currently, radionuclide studies offer the simplest and most accurate means of determining the patency of CSF shunts. The selection of the best test procedure depends upon the type of hydrocephalus and the type of shunt which has been inserted. This review documents the development of radionuclide shunt patency tests and suggests the optimum test procedure for a given clinical problem.

Adolescent↗
PubMed1976

Gallbladder visualization in adrenal scanning: case report.

A patient suspected of having adrenal hyperfunction was scanned with 131I-iodocholesterol. Intense gallbladder activity persisted for several days and was eliminated by a fatty meal. The possibility of confusion with unilateral adrenal localization is discussed.

Adrenal Gland Diseases↗
PubMed1975

Endotoxin as a cause of aseptic meningitis after radionuclide cisternography.

The role of pyrogens in aseptic meningitis after radionuclide cisternography was studied by means of the Limulus test, a sensitive detector of endotoxin. During a 15-month period, 39 reactions associated with cisternography were reported. Ten samples of specific lots of the radioactive drugs implicated in 20 of these reactions were tested and all reacted strongly positive to the Limulus test. The less sensitive rabbit pyrogen test was negative for these preparations when tested on a dose-per-weight basis. Our findings apparently provide clinical evidence for the observation made in animals that endotoxin is at least 1,000 times more toxic intrathecally than intravenously. The data implicate endotoxin contamination as a cause of adverse reactions to radionuclide cisternography. We conclude that the USP pyrogen test is insufficiently sensitive for intrathecal injectables and should be supplemented by the Limulus test.

Arachnida↗