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Biomedical subjects

J C Holder

Publications and source records attributed to J C Holder.

14 recordsLinked to original sources
PubMed1992

Differentiation of human prostate cancer from benign hypertrophy by in vitro 1H NMR.

In vitro 1H NMR spectra were acquired for perchloric acid extracts of tissue samples of human prostate. Seven patients were diagnosed with prostate cancer, 13 with benign prostatic hypertrophy, and 3 with both conditions. Statistically significant differences between the cancer and benign groups were seen for the metabolite peak area ratios of citrate, creatine, and phosphorylcholine to alanine, and citrate to glutamate. There was no correlation of Gleason grade with any of the ratios measured for the cancer samples. Spectra from different sections of large tumors often yielded substantially different area ratios, confirming the heterogeneous nature of these prostate tumors.

Alanine↗
PubMed1990

The preferential uptake of very-low-density lipoprotein cholesteryl ester by rat liver in vivo.

The removal from the blood and the uptake by the liver of injected very-low-density lipoprotein (VLDL) preparations that had been radiolabelled in their apoprotein and cholesteryl ester moieties was studied in lactating rats. Radiolabelled cholesteryl ester was removed from the blood and taken up by the liver more rapidly than sucrose-radiolabelled apoprotein. Near-maximum cholesteryl ester uptake by the liver occurred within 5 min of the injection of the VLDL. At this time, apoprotein B uptake by the liver was only about 25% of the maximum. Maximum uptake of the injected VLDL apoprotein B label was not achieved until at least 15 min after injection, by which time the total uptakes of cholesteryl ester and apoprotein B label were very similar. The results suggest that preferential uptake of the lipoprotein cholesteryl ester by the liver occurred before endocytosis of the entire lipoprotein complex. The fate of the injected VLDL cholesteryl ester after its uptake by the liver was also monitored. Radiolabel associated with the hepatic cholesteryl ester fraction fell steadily from its early maximum level, the rate of fall being faster and more extensive when the fatty acid, rather than the cholesterol, moiety of the ester was labelled. By 30 min after the injection of VLDL containing [3H]cholesteryl ester, over one-third of the injected label was already present as [3H]cholesterol in the liver. When VLDL containing cholesteryl [14C]oleate was injected, a substantial proportion (about 25%) of the injected radiolabelled fatty acid appeared in the hepatic triacylglycerol fraction within 60 min: very little was present in the plasma triacylglycerol fraction at this time.

Animals↗
PubMed1990

The preoperative prevalence and postoperative incidence of thromboembolism in patients with hip fractures treated with dextran prophylaxis.

A prospective preoperative and postoperative venographic study of hip fracture patients has documented a significant preoperative prevalence and postoperative incidence of thromboembolic disease. A statistically higher incidence of deep-venous thrombosis is observed in patients with femoral neck fractures compared to patients with intertrochanteric fractures. A 9% (15 of 176) preoperative prevalence and an 11% (12 of 108) incidence of new postoperative thromboembolic disease were detected. There was a predilection for deep-venous thrombosis in the injured extremity compared to the noninjured extremity both preoperatively and postoperatively.

Adult↗
PubMed1978

Choosing a contrast material for aortofemoral runoff angiography.

Aortofemoral runoff angiography was performed 63 times in a total of 21 patients, each of whom was injected three times with different contrast materials (60% methylglucamine iothalamate, 78%) sodium methylglucamine iothalamate, and 76% sodium methylglucamine diatrizoate). Neither the examiner nor the patient was aware which contrast material was being given. Significantly fewer patients reported severe injection pain with methylglucamine iothalamate than with the other two agents.

Aortography↗
PubMed1978

The use of a tip deflecting guide in untying a knotted arterial catheter.

Although knot formation occurs only rarely in the distal portions of angiographic catheters, its prompt recognition and the knowledge of various techniques for untying the knot can avoid surgery. The authors describe a unique method for untying a catheter knot using a 60 cm .035-in tip deflecting guide.

Aged↗
PubMed1977

Renal carcinoma: diagnostic and therapeutic aspects.

Angiographic diagnosis of renal cell carcinoma depends primarily upon the demonstration of abnormal vasculature within the tumor. Unless the renal vein is well visualized on the arteriogram, a venacavogram and renal venogram should be performed to detect tumor in these vessels. At present, the only effective treatment for renal carcinoma is radical nephrectomy.

Adenocarcinoma↗
PubMed1976

Preoperative diagnosis of xanthogranulomatous pyelonephritis.

Preoperative diagnosis of xanthogranulomatous pyelonephritis may be correctly made in a significant proportion of affected patients thus preventing unnecessary radical surgery especially in the poor-risk patient. The diagnosis should be suggested in the patient with a history of chronic urinary tract infection and certain radiologic features. These include unilateral renal enlargement (either localized or diffuse), nonfunction on excretory urography, presence of renal and/or ureteral calculi, angiographic demonstration of avascular mass or masses with stretched, attenuated intrarenal vessels, prominent capsular and periureteric vessels, and an irregular impaired nephrogram with prominent avascular areas.

Angiography↗
PubMedDate not supplied

Needle placement of myelography.

Proper placement of the entire bevel of the spinal needle within the subarachnoid space at myelography is necessary to prevent partial extra-arachnoid deposition of the contrast medium. A Cuatico aspiration cannula passed through the spinal needle at the time of spinal puncture serves to indicate the depth of the needle tip within the subarachnoid space.

Humans↗