Biomedical subjects

J C J M Veraart

Publications and source records attributed to J C J M Veraart.

3 recordsLinked to original sources

PubMed2003

[Favorable results with duplex-guided compression sclerotherapy for varices of the small saphenous vein; a retrospective study].

OBJECTIVE: Assessment of the efficacy of duplex-guided compression sclerotherapy in patients with varices of the small saphenous vein (SSV). DESIGN: Retrospective. METHOD: Data were collected from 109 patients (14% male and 86% female; average age 51.4 years (SD: 10.6)) with 121 SSV varices which were sclerosed under duplex guidance with polidocanol 3% during the period 1 December 1998-31 May 2001 in the Dermatology department at Maastricht University Hospital, the Netherlands. After-care consisted of a compression bandage for 1 week and a therapeutic elastic stocking for 6 weeks. Check-ups took place after 3-6 months and after 12 months. Sclerosis was repeated if the procedure had failed. Success was defined as occlusion or by the absence of reflux and a reduction in the complaints. RESULTS: After 3-6 months the treatment was successful in 88/113 varices (78%) for which data were available, and after 12 months treatment was successful in 46/57 (81%). CONCLUSION: Sclerosis of the SSV under duplex guidance, with repeat treatment if required, gave favourable results.

Female↗

PubMed2002

[Chronic venous insufficiency].

Chronic venous insufficiency (CVI) is a complex of symptoms occurring on the lower leg, which includes varicose veins, oedema, pigmentation and venous leg ulceration. Most patients have severe complaints, which result in a high medical consumption, mainly due to venous leg ulceration. CVI is caused by a decompensation of the venous system together with reflux in the superficial, deep and/or perforating veins of the lower leg in supine position. The exact pathogenesis of the skin symptoms is still largely unclear. An increased walking venous pressure induces macrocirculatory and microcirculatory changes such as dermal pericapillary fibrin cuffs, leukocyte accumulation and the activation of cytokines. CVI can be treated in several ways: compression therapy, if needs be combined with sclerotherapy or surgery, or with supportive medication.

Bandages↗

PubMed2002

Recurrent leg ulcers in a young man with hyperhomocysteinemia, factor V Leiden and impaired fibrinolysis.

We present a young male patient referred to our hospital with leg ulcers on both legs that were more than 3 years refractory to standard treatment with compression therapy. By thrombophilia screening factor V Leiden mutation, hyperhomocysteinemia and evidence for impaired fibrinolysis were found. Treatment with folic acid in combination with long-term oral anticoagulant therapy was added to non-elastic compression therapy. The leg ulcers showed slow improvement and complete healing within 3 years. During a 6-year follow-up period neither new thrombo-embolic events occurred nor recurrence of ulcerations. This case suggests a potential synergistic pathogenic role of factor V Leiden, hyperhomocysteinemia and impaired fibrinolysis in the development of postthrombotic syndrome and his sequelae. We postulate that increased formation of thrombi in the microcirculation of the skin in combination with ambulatory venous hypertension due to recurrent deep venous thrombosis might explain our observation.

Adrenal Cortex Hormones↗