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J C Koetsier

Publications and source records attributed to J C Koetsier.

33 records · Page 2Linked to original sources
PubMed1988

Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat.

Experimental allergic encephalomyelitis (EAE) in Lewis rats is an acute monophasic autoimmune disease. It can be treated prophylactically and therapeutically with high doses of cyclosporin A (CsA). Here we demonstrate that low-dose CsA does not prevent a first attack of EAE, but, on the contrary, induces a chronic relapsing form of the disease in 100% of Lewis rats examined. Possible explanations for the high relapse rate after low-dose CsA treatment are discussed. Further studies will be needed to evaluate the immunological mechanisms responsible for these results.

Animals↗
PubMed1988

Neuromyelitis optica (Devic's syndrome): not always multiple sclerosis.

A patient is presented with clinical signs and symptoms of neuromyelitis optica (Devic's syndrome). The clinical findings, the cerebrospinal fluid findings and the Magnetic Resonance Imaging findings in our patient demonstrate that neuromyelitis optica is not always a form of Multiple Sclerosis. It can also be a manifestation of other demyelinating diseases, for example Disseminated Encephalomyelitis.

Adolescent↗
PubMed1987

Cerebrospinal fluid cells in multiple sclerosis and other neurological diseases: an immunocytochemical study.

Determinations of mononuclear cell subsets in cerebrospinal fluid (CSF), using monoclonal antibodies against surface antigens which identified pan T-cells, helper/inducer T-cells, cytotoxic/suppressor T-cells and Ia-positive cells, were performed in patients with multiple sclerosis (MS), other neuroimmunological diseases (NID), infectious diseases (INF) of the central nervous system and with other neurological diseases. Whereas there was an elevated helper T/suppressor T ratio in CSF of patients with NID (Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, cerebral vasculitis), no other significant differences could be detected between the different groups of patients. Our results suggest that analysis of these mononuclear cell subsets in CSF is not helpful in discriminating between MS and other neurological diseases and that in MS patients changes in disease activity are not clearly indicated by fluctuations in the different CSF cell subsets. Further studies will be needed to confirm our findings in NID patients and to understand the diagnostic and theoretical implications.

Cell Count↗
PubMed1987

Macrophages in the central nervous system of the rat.

In an immunohistochemical study using monoclonal antibodies, which exclusively recognize cells of the monocyte-macrophage lineage, and monoclonal antibodies against the Ia-antigen, we describe the occurrence of macrophages in the developing and adult central nervous system (CNS). In normal adult brain, no macrophages could be detected in the CNS parenchyma; only in the meninges and the choroid plexes were a few macrophages found. During ontogeny, numerous phagocytic cells infiltrated the CNS parenchyma; these cells which did not express Ia are blood-borne. About three weeks after birth, all macrophages had disappeared from the CNS. As microglia in adult and developing brain do not stain with the anti-macrophage antibodies, we suggest that microglial cells are not related to the mononuclear phagocyte system and do not have a hematogenous origin.

Animals↗
PubMed1987

Presence of Ia-positive cells in the central nervous system of the rat during various pathological conditions.

The rat central nervous system (CNS) was analyzed immunohistochemically during various pathological conditions by using monoclonal antibodies specific for rat T lymphocytes, rat macrophages and Ia antigen. It was found that in immunologically mediated disease infiltrating macrophages do express the Ia antigen, whereas in nonimmunologically mediated disease they do not. The results suggest that based on the composition of the mononuclear phagocyte infiltrate a clear distinction can be made between different inflammatory reaction types within the CNS.

Animals↗
PubMed1986

Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis.

Inflammatory cells were characterized by immunohistochemistry, utilizing monoclonal antibodies specific for T cell subsets, B cells, Ia-positive cells and cells of the mononuclear phagocyte system, in cryostat sections of central nervous system of Lewis rats, sacrificed during the course of actively induced experimental allergic encephalomyelitis. The present study provides interesting information about the presence and distribution of cells of the monocyte-macrophage lineage in this immunologically mediated disease. Using these monoclonal antibodies different subpopulations of macrophages having varying distribution patterns in the central nervous system can be recognized.

Animals↗
PubMed1985

Multiple sclerosis: incorporation of results of laboratory techniques in the diagnosis.

In a retrospective study of 100 multiple sclerosis patients we compared the diagnostic classification according to the Schumacher/Rose criteria and the newest criteria, proposed by Poser et al. It is clear that by incorporating the results of laboratory investigations in the diagnostic criteria a firm diagnosis of multiple sclerosis can be reached more often and at an earlier stage of the disease. Evaluating abnormal laboratory findings, we found that it was possible to detect more than 90% of diagnostically important findings, i.e. findings effecting a change in diagnostic classification (from possible multiple sclerosis to probable or definite, from probable to definite), using only two of the laboratory tests: cerebrospinal fluid analysis and visual evoked response. Because the results of laboratory tests contributing to diagnostic classification are not specific for multiple sclerosis, the importance of evaluating the complete differential diagnosis of diseases that can be confused with multiple sclerosis is stressed.

Adolescent↗
PubMed1983

Computed tomography in acute cerebral multiple sclerosis. A report of two cases.

In two cases of acute cerebral multiple sclerosis, computed tomographic (CT) scans with contrast disclosed several enhanced foci, mainly situated in the periventricular white matter and, in one patient, in the cerebellum. Administration of dexamethasone sodium phosphate in one patient and prednisone with cyclophosphamide in the other was followed by considerable clinical improvement. Successive CT scans with contrast enhancement showed a close correlation between improvement of symptoms and the subsidence of contrast-enhanced foci during treatment. Perhaps clinical improvement reflected restoration of the impaired blood-brain barrier.

Adult↗
PubMed1977

Evaluation of the red blood cell cytopherometric test for the diagnosis of multiple sclerosis.

The effect of linoleic acid on the electrophoretic mobility of red blood cells from both MS patients and normal subjects was studied. An extensive statistical evaluation of the data clearly demonstrated that there was no difference in behaviour of red blood cells from patients and normal subjects in the presence of linoleic acid. Even a tendency for the mobility of erythrocytes to be decreased in patients and increased in normal subjects after addition of linoleic acid was not observable.

Electrophoresis↗