Potential endocervical pathogens before termination.
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Abortion, Induced↗
Biomedical subjects
J C Konje
Publications and source records attributed to J C Konje.
The effect of continuous subdermal levonorgestrel (Norplant) on carbohydrate metabolism.
Blood glucose and plasma insulin levels during an oral glucose tolerance test were measured in 20 women using continuous subdermal levonorgestrel (Norplant) for contraception over a 12-month period. Changes in carbohydrate metabolism occurred as early as 1 month but were most marked after 6 months. After 1 month the area under the glucose and insulin curves increased by 12.3% and 37.7%, respectively. This increase was more marked by 6 months, but by 12 months it was significantly less marked. Although changes in the blood glucose and plasma insulin levels at different times during the oral glucose tolerance test occurred, they were all within normal limits for normal women. The peak blood glucose and insulin levels after insertion of the implant occurred 60 minutes after the glucose load, as opposed to 30 minutes before insertion. Apart from this, there was a significant delay in the return of these levels to fasting values. We conclude that this product, like any other progesterone-containing contraceptive, alters carbohydrate metabolism, but these alterations are not clinically significant in normal women. It is, however, possible that in potential cases of diabetes it may predispose to frank diabetes.
Adult↗
Carbohydrate metabolism before and after Norplant removal.
Changes in carbohydrate metabolism, measured by oral glucose tolerance test, were studied in Norplant users before and after removal. The mean area under the glucose curve rose from 24.7 min mmol/L before Norplant insertion to 35.1 min mmol/L before removal and decreased to 26.1 min mmol/L four weeks after Norplant removal. The areas before insertion and after removal were not statistically different (95% confidence interval -3.3 to 0.56, P = 0.16). The mean areas under the insulin curves before insertion (53.14 min uU/L) and after removal (59.46 min uU/L), however, were significantly different (95% confidence interval -7.64 to -5.0, P less than 0.0001). We conclude that changes in carbohydrate metabolism induced by Norplant are reversible once the implants are removed. While the changes in glucose induced by Norplant returned to pre-insertion levels within 4 weeks after removal, insulin changes were slower to return to pre-insertion values.
Adult↗
Health and economic consequences of septic induced abortion.
Over a period of 7 years, 230 cases of illegally induced abortions complicated by sepsis were treated at the University College Hospital, Ibadan, Nigeria. The number of terminations complicated by sepsis doubled from 25.4 (between 1981 and 1985) to 51.0 (between 1986 and 1987) cases per year. Peritonitis was the commonest associated complication while maternal mortality was 8.3%. The average cost of treatment was US$223.11, while the average monthly earnings was US$45.00. Legalization of abortion would have resulted in a saving of US$50,022.28. Provision of legal abortion would reduce the incidence of sepsis after termination while reproductive health education and information dissemination and provision of easily accessible family planning services would greatly reduce the number of unwanted pregnancies.
Abortion, Illegal↗
Presentation and management of eclampsia.
Three hundred forty-seven cases of eclampsia were managed at the University College Hospital (UCH), Ibadan, Nigeria from 1977 to 1986 (9.3 per 1000 deliveries). Thirty-one percent of seizures occurred antenatally, 46.2% during labor and 23.2% postnatally. Only 5% first occurred in the hospital. Seizures were controlled with diazepam, lytic cocktail (chlorpromazine, pethidine and phenergan), sodium amylobarbitone, paraldehyde and bromethol. Maternal mortality was 2.9%, and perinatal mortality 193 per 1000, respectively. Prevention of avoidable factors (absent or poor antenatal care and prolonged labor) by the provision of comprehensive antenatal care will reduce the incidence of eclampsia. Improvement in management facilities prior to transfer to referral centers, the use of magnesium sulfate or diazepam to control seizures and the avoidance of hypotonic solutions and 50% glucose during therapy will reduce morbidity and mortality.
Adolescent↗
Obstructed labor in Ibadan.
Over a period of 13 years, 380 cases of obstructed labor were managed amongst 39,456 deliveries. Absent prenatal care and poor intrapartum care at peripheral hospitals were major contributing factors. The average duration of labor in those with obstruction was three times that in the normal obstetric population. About 82% of patients with obstruction had an emergency cesarean section while 10% had destructive operations. The main etiological factor was unrecognised positional disproportion. Common associated complications were ruptured uterus, genital and wound sepsis. Maternal and perinatal morbidity and mortality were high. Adequate health education, incorporation of traditional birth attendants into health care programs and the provision of more health care centers will reduce the occurrence of this complication.
Adolescent↗
Early teenage pregnancies in Hull.
OBJECTIVES: To determine the pattern, obstetric outcome and factors that predispose to pregnancies in young teenagers in Hull. DESIGN: Retrospective study of case records of pregnancies from 1977 to 1988 in girls aged 16 years or less and in a control group of nulliparous women aged 20-24 years. SETTING: Hull health district hospitals. SUBJECTS: 1,660 pregnant teenagers and 3,576 nulliparas aged 20-24 years. MAIN OUTCOME MEASURES: Ages at pregnancy, number of pregnancies per year, gestational age at booking and delivery, antenatal complications, mode of delivery, utilization of contraceptives and some social factors. RESULTS: Of the 1,660 pregnancies in the young adolescents, 59-6% were terminations. The youngest girl was 11. The average annual incidence of early teenage pregnancies was 10.5 per 1,000 girls aged 10-16 compared to 6.4 per 1,000 in England and Wales. Physical characteristics and pattern of antenatal care were similar in the study and control groups. Anaemia was 2.53 times as common in teenagers (95% CI 2.19-2.9; P < 0.0001) while hypertension alone was 1.7 times as frequent (95% CI 1.28-2.4; P = 0.002). Pre-eclampsia and proteinuric disorders were similar in the two groups. Apart from prolonged pregnancy, which was significantly less common in the index group, other gestational ages at delivery and birthweights were the same in both groups. The caesarean section rate in the index group was 0.56 times that in the control group (95% CI 0.4-0.75; P < 0.0001) but forceps deliveries were 2.37 times as common in the index group (95% CI 1.80-3.12; P < 0.0001). The uncorrected perinatal mortality rates were 13.6/1000 and 15.7/1000 in the index and control groups respectively. CONCLUSION: Early teenage pregnancies are common in Hull and, contrary to previous reports, are physically well tolerated by the early adolescents who book early and attend antenatal clinics regularly. Ineffective utilization and ignorance of contraceptive methods are contributory factors. We recommend that emphasis should be placed on providing contraceptive services for teenagers and adopting a more purposeful and holistic approach to sex education.
Abortion, Legal↗
Insecticide poisoning in pregnancy. A case report.
A 25-year-old multigravida drank an organochlorine insecticide in an attempt to commit suicide at 16 weeks of pregnancy. This resulted in the death of twin fetuses and vaginal bleeding. The pregnancy was terminated using gemeprost, syntocinon and later surgical evacuation of the uterus. She developed respiratory arrest after the fetuses were aborted and also after surgical evacuation. On both occasions, she was intubated and mechanically ventilated. We believe that organochlorine insecticides may be fetocidal. In addition, surges in blood levels may occur during termination of pregnancy, delivery or evacuation of retained products of conception.
Adult↗
Prevention of IUD-related pelvic infection: the efficacy of prophylactic doxycycline at IUD insertion.
It is believed that much of the small increased risk for developing pelvic inflammatory disease (PID) associated with the use of an intrauterine device (IUD) appears to be caused by bacterial contamination of the endometrial cavity at the time of insertion. Previous research suggests that use of prophylactic antibiotics immediately prior to IUD insertion may reduce the risk of developing PID. This paper presents results from a randomized clinical trial of 1485 women in Ibadan, Nigeria evaluating the effectiveness of 200 mg of doxycycline (versus placebo) given orally at the time of IUD insertion in reducing the incidence of PID during the first three months of IUD use. Rate of PID infection in the doxycycline-treated group was not significantly lower than that in the placebo-treated group. The rate of unscheduled IUD-related visits to the clinic also was not significantly lower among the doxycycline-treated group. However, the incidence of PID was low (21 cases) for both study groups. Aseptic conditions during IUD insertion, follow-up visits with short intervals to monitor health, and treatment of opportunistic infections may have reduced the potential of PID within this population.
Administration, Oral↗
Changes in carbohydrate metabolism during 30 months on Norplant.
During a 30-month period, changes in carbohydrate metabolism (measured by oral glucose tolerance test) were studied in 20 Norplant acceptors. Changes were first observed one month after Norplant insertion and peaked between 12-18 months. The area under the glucose curve rose by 12.3% and 40.5% one and 12 months post insertion, respectively. At 18, 24 and 30 months the rise was, respectively, 41.9%, 40% and 38.6%. Although the changes under the insulin curves were similar, the increase at one month was doubled (25.7%). Only fasting insulin values showed very slight and insignificant changes during the 30-month period. All the changes were, however, within the normal limits for healthy women. We conclude that although Norplant induces changes in carbohydrate metabolism, these changes remain within normal limits, peak at 12 months and either remain the same or decrease with time.
Adult↗
Septic abortion at University College Hospital, Ibadan, Nigeria.
One hundred forty-three cases of septic abortion managed over 5 years are reviewed. Sepsis was more common after induced abortion often performed by non-gynecologists. Instrumentation was commonly performed in the homes, chemists and poorly equipped private clinics. Complications were generally severe and maternal mortality was 8.4%. Treatment was individualized but there was no standard antimicrobial regime.
Abortion, Induced↗
The prevalence of Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans in the cytology clinic at Ibadan, Nigeria.
In a study of 2224 adult women from the cytology clinic of the University College Hospital, Ibadan, Nigeria, the prevalence of 'specific vaginal infection' (i.e. Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans) was 14.5%. For individual organisms, the rates were 9.76% for G. vaginalis, 2.52% for T. vaginalis and 2.20% for C. albicans. About half of the patients were asymptomatic while others were referred from other clinics with vaginal discharge, cervical erosion, post-coital bleeding, intermenstrual bleeding and various other symptoms and signs. The infections were almost uniformly distributed in all age groups studied. Increasing promiscuity either as a result of increased mobility of husbands (due to economic depression) or increased use of contraception by older women was thought to be responsible for the persistence of these infections in those aged 45 years and above. In addition, Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans infections can also be easily diagnosed from cervical cytology, by identification either of the organism or of characteristic cytological cellular changes.
Adult↗
Cervical cancer screening at Ibadan.
Over a period of 44 months, 3171 smears were performed at the University College Hospital (UCH). Ibadan, Cytology Clinic. Of these, 44.2% were in asymptomatic women. Fifty-five point three percent were normal; 15.6% of the smears were reported as non-specific inflammatory changes while 20.1% were due to specific infections. Varying degrees of cervical intra-epithelial neoplasia (CIN) were diagnosed in 8.4% of the smears. The abdominal smears were treated with chemotherapy, cryocautery, diathermy, cone biopsy and hysterectomy. A simplified management plan for a patient with an abnormal smear based on our experience is also presented.
Adult↗
Ruptured uterus in Ibadan--a twelve year review.
Maternal mortality and morbidity have remained very high in the developing countries. A common cause is ruptured uterus. In this report of 227 cases of ruptured uterus, the incidence was found to be rising. About 71.4% of the cases lacked prenatal care while 48.4% had a previously scarred uterus with many of them laboring for more than 12 h. The most common etiological factor was prolonged labor. Maternal mortality was 7.5% while perinatal mortality was 62.0%. Labor in high risk patients outside hospital because of declining economy and the rising influence of religion were some of the predisposing factors implicated. Methods to reduce this obstetric catastrophe are discussed.
Adolescent↗
Burkitts lymphoma of the ovary in Nigerian adults--a 27-year review.
Ten cases of adult Burkitts lymphoma managed over a 27-year period at the University College Hospital, Ibadan were reviewed. The incidence of adult ovarian Burkitts over the period was 1.3%. Menstrual abnormalities and abdominal masses were the most common symptoms while bilateral multinodular ovarian masses were the most constant findings at laparotomy. Diagnosis was mainly by histopathology. Surgery and chemotherapy were the main modalities of treatment. Mortality was high with cerebral metastases being the most common cause of death.
Adult↗