Biomedical subjects

J C Louis

Publications and source records attributed to J C Louis.

75 records · Page 5Linked to original sources

PubMed1978

Urihesive: a new aid in the management of urinary incontinence in male paraplegic patients.

Our past practice with incontinent paraplegic patients has been to attach to the penis the sheath incorporated in urinary drainage devices by means of Elastoplast tape. Frequent development of skin lesions due to local irritation, and the necessity to wind Elastoplast tightly around the penis, which may produce urethral diverticula, has led us to use Urihesive to attach the sheath to the urinary drainage device. Urihesive has been used continuously for several months in 18 paraplegic patients. It has proved to be highly superior to Elastoplast, for the following reasons: It produces a better seal, resulting in no leakage of urine, and has better elasticity; it prevents the development of skin lesions and aids healing to existing lesions; there is no urethral constriction and the patient is more comfortable.

Adhesives↗

PubMedDate not supplied

Ciliary neurotrophic factor (CNTF) promotes low-affinity nerve growth factor receptor and CD4 expression by rat CNS microglia.

Ramified parenchymal microglia may provide immune surveillance in the nervous system and become activated in response to injury, showing increases in antigens found on macrophages, e.g. CD4 and MHCs. We investigated in adult rats the effects of a 2-week intraventricular infusion with ciliary neurotrophic factor (CNTF), a nervous system-associated cytokine, on microglia of the normal and injured corpus callosum. CNTF caused morphological changes, induced the expression of low-affinity nerve growth factor receptor and CD4 and increased the expression of complement receptor 3. Such changes were also observed after treatment of pure cultures of neonatal rat microglial cells with highly purified CNTF, suggesting a direct responsiveness to CNTF. Thus, endogenous astroglial and Schwann cell-derived CNTF may be an important component of the immune responses of the nervous system.

Animals↗

PubMedDate not supplied

[Pharmacologic complications of the unequal reactivity of constituent elements of the myocardium to the parasympathetic system].

Pharmacological consequences of the unequal reactivity of the myocardial different parts to parasympathic system. The effects of acetylcholine on the various levels of cardiac automatism are studied on open chest dogs with extracorporeal circulation. This drug depresses the sinus node, and more specially the atrio-ventricular node (AV node), but does not alter the His bundle and the Purkinje fibers activity. The sensitivity of the intra-cardiac conduction to acetylcholine also depends upon the considered level of conduction: measured with a bipolar electrode situated upon the His bundle, this one is lowered electively in the atrio-ventricular part. So, the A, V. node can be considered as the elective place of action of acetylcholine on the double point of view of automatism and conduction. Drugs modifying the vagal tonus see their action altered, either in a plus way (antiarrhythmic agents), either in a minus way (cardiac glycosides, halogenated hydrocarbons).

Acetylcholine↗