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J C Maize

Publications and source records attributed to J C Maize.

At least 55 records · Page 3Linked to original sources
PubMed1988

A new method for the comprehensive automatic morphologic image analysis of Langerhans cells.

Standard techniques used to study Langerhans cell (LC) populations are tedious and time-consuming. We developed a rapid and comprehensive method to evaluate LC using automatic digital image analysis. Human epidermal sheets were stained with OKT6 monoclonal antibody and evaluated on an IBAS 2000 computerized automatic digital image analysis system. The fields were imaged on a Photomicroscope I using a high-resolution monochrome video camera. Each field was digitized, normalized, and filtered. The LC were discriminated by density; each field was interactively edited to separate overlapping cells and to bridge small gaps in the dendrites. The discriminated binary image of the LC was measured for number of cells per field, total area of individual cells per field, and percent of the field occupied by LC. The cell bodies were then separately discriminated and subtracted from the thinned cell image to allow a separate measurement of number and length of dendrites per cell. Finally, the binary cell image in a reference section was dilated to occupy approximately the total field area. This degree of dilation was then applied to all subjects to give the "area of influence." This methodology provides a rapid and comprehensive tool for the evaluation of LC.

Autoanalysis↗
PubMed1988

Papillary eccrine adenoma. A light microscopic and immunohistochemical study.

The papillary eccrine adenoma is a rare benign sweat gland neoplasm characterized by a potentially locally aggressive clinical course. The light microscopic findings in two cases of this unusual neoplasm are discussed, with emphasis on the differential diagnosis of this tumor from other benign and malignant sweat gland neoplasms. Immunohistochemistry studies directed against various epithelial antigens were also performed. Immunoperoxidase stains positive for carcinoembryonic antigen, S-100 protein, and epithelial membrane antigen strongly support the hypothesis that this unusual neoplasm differentiates toward the eccrine secretory coil.

Antigens↗
PubMed1988

Mucosal melanosis.

The labial melanotic macule has an increased number of dendritic melanocytes along the basal layer. Numerous counterparts of the labial melanotic macule occur on the other mucosal and cutaneous surfaces. Most melanoacanthomas of the lip show a similar number of melanocytes along the junctional zone. Melanoacanthoma of the lip differs histologically from the labial melanotic macule by the presence of intraepithelial dendritic melanocytes. It also has histologic counterparts that occur on other oral mucosal surfaces. Primary acquired melanosis of the conjunctiva is biologically different from the other mucosal melanoses because it frequently progresses to malignant melanoma. All mucosal melanoses must be taken seriously by the physician, because it is usually not possible to exclude malignant melanoma on clinical inspection alone. A biopsy is always indicated. The labial melanotic macule and melanoacanthoma demonstrate histologic features strikingly different from those of melanoma. Although intraepithelial dendritic melanocytes are seen in melanoacanthoma, they are mostly present in the lower portions of the epithelium, and there is no full-thickness haphazard dispersion of atypical single and nested melanocytes. Along the basal layer in melanotic macules and melanoacanthomas of the lip, melanocytes are arranged as solitary units without a tendency to form abnormal nests or become confluent, in contrast to the picture in melanoma. Melanocytes in this zone show no pleomorphism, in contradistinction to the often bizarre, atypical melanocytes seen in melanoma.

Conjunctiva↗
PubMed1987

Melanotic macules and melanoacanthomas of the lip. A comparative study with census of the basal melanocyte population.

Fifteen labial melanotic macules and three melanoacanthomas of the lip were studied with particular regard to their distinguishing histopathological features including a quantitative study of the basal melanocyte population. Both of these entities show an increased population of melanocytes arranged as single units along the junctional zone. These conditions differ from each other primarily by the presence of intraepithelial melanocytes in melanoacanthoma. In our opinion, the melanotic macule of the lip has numerous histological counterparts that occur on other mucosal and cutaneous surfaces. Oral mucosal analogies to the labial melanoacanthoma also exist.

Adult↗
PubMed1987

Subcutaneous phaeohyphomycosis caused by Exserohilum rostratum in an immunocompetent host.

A healthy, 55-year-old woman developed a subcutaneous abscess and systemic symptoms of nausea, dizziness, and chills following minor trauma to her leg. Histopathologic examination of a skin biopsy specimen revealed golden-brown colored mycelial elements, and culture resulted in growth of a dematiaceous fungus identified as Exserohilum rostratum. Surgical excision of the abscess and concomitant oral therapy with ketoconazole resulted in resolution of symptoms. In previously reported cases of human phaeohyphomycosis caused by Exserohilum and related Bipolaris species in both immunocompromised and immunocompetent hosts, treatment has varied from topical antimicrobial therapy to combined surgery and intravenous antifungal chemotherapy. Our experience leads us to believe that surgical débridement of an accessible focus of infection along with orally administered ketoconazole may provide adequate therapy in an immunocompetent host.

Abscess↗
PubMed1986

Bronchial mucoepidermoid carcinoma metastatic to skin. Report of a case and review of the literature.

A case of bronchial mucoepidermoid carcinoma is reported, the presentation of which was as cutaneous metastases. Histologic, histochemical, and ultrastructural features of the neoplasm are described, and the literature pertaining to bronchial mucoepidermoid carcinoma is reviewed. This case illustrates the potential for aggressive behavior in a mucoepidermoid neoplasm, the histologic features of which are considered low grade by some authors. Because such metastatic lesions may be morphologically identical to tumors that have been described as primary cutaneous mucoepidermoid carcinomas, this differential must be considered by the histopathologist confronted by such a neoplasm.

Adult↗
PubMed1986

Histologic evolution of recurrent basal cell carcinoma and treatment implications.

The pathologic specimens from forty-seven patients with fifty-one recurrent basal cell carcinomas referred for Mohs' surgery were studied. Specimens from the original tumor and from each subsequent recurrence were reviewed. Of the original tumors, 65% demonstrated an aggressive* histologic picture characterized by poor palisading and an infiltrating and/or micronodular pattern. In twelve cases the recurrent tumor developed a more aggressive histologic picture, but in seven cases the histologic picture became more benign. Electrodesiccation and curettage was the initial treatment for forty-one basal cell carcinomas. Ten tumors had been excised previously, with routine pathologic examination indicating tumor-free margins in six of these lesions. It can be concluded that many recurrent basal cell carcinomas are aggressive from the beginning, and this often can be predicted from the histologic picture. Lesions with an aggressive pathologic picture should not be managed by blind technics such as electrodesiccation and curettage and may defy routine pathologic examination of conventional excision specimens. Mohs' surgery appears to be the treatment of choice for such lesions.

Basal Cell Carcinoma↗
PubMed1986

Follicular lymphomatoid papulosis.

A patient with follicular lymphomatoid papulosis is reported. Only two cases of this rare variant have been previously reported in the literature. Lesions typical of lymphomatoid papulosis in this case were centered around disrupted hair follicles. They corresponded to the type A "histiocytic" variant of lymphomatoid papulosis. The histologic features and theories regarding histogenesis of this unusual disorder are discussed.

Adult↗
PubMed1985

Malignant melanoma simulating schwannian differentiation.

A malignant melanoma demonstrating palisades of spindled melanocytes strikingly similar to Verocay bodies is reported. Immunohistochemical staining for S-100 protein and neuron-specific enolase revealed uniform positive staining of the neoplastic cells consistent with malignant melanoma. Immunohistochemical staining for myelin basic protein, a marker specific for Schwann cells, was negative in neoplastic cells. Ultrastructural examination revealed numerous melanosomes, confirming the melanocytic nature of this neoplasm. The differential diagnosis and possible histogenesis of this neoplasm are discussed.

Aged↗
PubMed1985

Pyostomatitis vegetans.

Pyostomatitis vegetans is a rare and unusual disorder of the oral cavity, characterized by erythema and edema of the mucosa and numerous small, superficial yellow pustules. Its significance lies in its association with inflammatory disease of the bowel, either ulcerative colitis or Crohn's disease. We report here a patient with pyostomatitis vegetans who, upon medical workup, was discovered to have asymptomatic Crohn's disease. The clinical features, histopathology, and treatment of pyostomatitis vegetans, and its purported relationship to pemphigus vegetans of Neumann are discussed.

Biopsy↗