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Biomedical subjects

J C McCauley

Publications and source records attributed to J C McCauley.

9 recordsLinked to original sources
PubMed1995

Resting energy expenditure in children with phenylketonuria.

Reports have suggested that children with phenylketonuria (PKU) weigh more compared with reference data. We found lower body protein and bone mineral density in children with PKU. These children may have a predisposition becoming overweight because of an alteration in body composition, which may lower resting energy expenditure (REE). REE was measured in 30 (15 males, 15 females) children with PKU (aged 9.6 +/- 2.9 y) and in 65 (23 males, 42 females) control children (aged 11.2 +/- 3.1 y). There was a comparable range in body fat within each group (control group: 11-34%; PKU group: 10-34%). The mean REE was similar between the male and female children with PKU (5300 +/- 757 and 4703 +/- 1024 kJ/24 h, respectively) and the control subjects (5306 +/- 969 and 5164 +/- 701 kJ/24 h, respectively). The children with PKU had an REE similar to that predicted from control data (males 102.1 +/- 7.8% of predicted and females 100.2 +/- 8.5% of predicted). This study found no evidence of a reduced REE or of increased weight in children with PKU.

Adolescent↗
PubMed1995

Indirect calorimetry in mechanically ventilated children: a new technique that overcomes the problem of endotracheal tube leak.

OBJECTIVES: To develop indirect calorimetry to enable measurement of energy expenditure in mechanically ventilated children and to assess the effect of endotracheal tube leak on the accuracy of indirect calorimetry measurements. DESIGN: Prospective, observational study, using a convenience sample. SETTING: Tertiary pediatric intensive care unit in a university-associated children's hospital. PATIENTS: Eighteen patients, 3 months to 10 yrs of age, with various diagnoses, and requiring mechanical ventilation. INTERVENTIONS: Patients were intubated and received routine intensive care treatment. MEASUREMENTS AND MAIN RESULTS: Energy expenditure and respiratory quotient were measured using a new modification to the technique of indirect calorimetry, which includes an assessment of any expired gas lost around the endotracheal tube. Mean energy expenditure was 97% of predicted energy expenditure, but there was great variability between patients, and energy expenditure could not be estimated reliably from predictive equations. The amount of expired gas lost because of gas leak around the endotracheal tube was often a clinically important proportion of total expired gas, and this lost gas could not be predicted by audible endotracheal tube leak. CONCLUSIONS: Measurement of energy expenditure by indirect calorimetry may be useful in the nutritional management of critically ill children. Results may be inaccurate if the gas lost because of leak around uncuffed endotracheal tubes is not taken into account.

Calorimetry, Indirect↗
PubMed1993

Development of a paediatric indirect calorimeter.

An indirect calorimeter was developed to measure resting energy expenditure (REE) and respiratory quotient (RQ) in a clinical paediatric population. The design is suitable for any child spontaneously breathing room air. Measurements are possible from small babies to large hypermetabolic adolescents due to the ability to set and control flow from the patient headbox across the range 2-40 l/min. The calorimeter is mobile, it is electrically safe and the patient interface may be disinfected. An alcohol burning technique, that can emulate a clinical test for children of various sizes, is used to check the system, which has a high level of accuracy across a range of conditions. The indirect calorimeter has been successfully used to measure a large number of children of different sizes.

Adolescent↗
PubMed1992

Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident: a randomized double-blind study.

A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enrolled in the trial and 31 satisfactorily completed the study. A modified Cybex isokinetic dynamometer was used to gather information on strength and muscle tone. Clinical, functional, and biochemical data were also collected. It was found that Dantrium reduced strength in the unaffected limbs but did not alter strength in the paretic limbs. Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study.

Aged↗