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Biomedical subjects

J C Meranger

Publications and source records attributed to J C Meranger.

12 recordsLinked to original sources
PubMed1989

Lead concentrations in human bones from the Canadian population.

Stable lead was determined in post-mortem samples of human bones from three Canadian cities. All age groups and both sexes were represented. The cities selected for investigation were Winnipeg, Montreal and Charlottetown. No significant difference was found between the locations, although levels tended to be higher for Montreal. Mean lead concentrations (micrograms Pb/g ash) were 8.98 +/- 1.17, 11.11 +/- 1.74 and 8.47 +/- 1.06 for Winnipeg, Montreal and Charlottetown, respectively. Corresponding geometric means were 6.21, 7.88 and 6.71, respectively. Individual values ranged from 0.45 to 240.07 micrograms Pb/g ash. Concentrations were highest in the greater than 20-year age group, indicating increased body burden with age. An increase in lead concentration was observed for the ages 1-11 years with a decrease for the 12-19-year age group. Differences in concentrations between the sexes were not significant. Higher than average concentrations were observed in samples obtained from Winnipeg for the period 1976-1980, particularly in the 1-4-year age group. A similar pattern was observed in the air lead concentrations, suggesting a possible correlation between the concentrations of lead in the air and in bones at Winnipeg.

Age Factors↗
PubMed1989

Respiratory health effects associated with ambient sulfates and ozone in two rural Canadian communities.

A cross-sectional epidemiological study investigating the respiratory health of children in two Canadian communities was conducted in 1983-1984 in Tillsonburg, Ontario, located in a region of moderately elevated concentrations of transported air pollutants, and in Portage la Prairie, Manitoba, situated in a low pollution area. There were no significant local sources of industrial emissions in either community. Seven hundred and thirty-five children aged 7-12 were studied in the first town and 895 in the second. Respiratory health was assessed by the measurement of the forced vital capacity (FVC) and forced expiratory volume in 1 sec (FEV1.0) of each child, and by evaluation of the child's respiratory symptoms and illnesses using a parent-completed questionnaire. Sulfur dioxide (SO2), sulfate, and particulate nitrate levels were significantly higher in Tillsonburg than in Portage la Prairie (P less than 0.05), but nitrogen dioxide (NO2) and inhalable particles (PM10) differed little between the communities. Historical data in the vicinity of Tillsonburg indicated that average annual levels of sulfates, total nitrates, and ozone (O3) did not vary markedly in the 9-year period preceding the study. The results show that Tillsonburg children had statistically significant (P less than 0.001) lower levels of 2% for FVC and 1.7% for FEV1.0 as compared with children in Portage la Prairie. These differences could not be explained by parental smoking or education, the use of gas cooking or wood heating fuels, pollution levels on the day of testing, or differences in age, sex, height, or weight. The differences persisted when children with cough with phlegm, asthma, wheeze, inhalant allergies, or hospitalization before age 2 for a chest illness were excluded from analysis. With the exception of inhalant allergies, which occurred more frequently in Tillsonburg children, the prevalence of chronic respiratory symptoms and illnesses was similar in the two communities.

Air Pollutants↗
PubMed1985

Kidney and liver levels of some major, minor and trace elements in two Ontario communities.

The contents of Ag, As, Ba, Be, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Mg, Mn, Mo, Na, Ni, P, Pb, Se, Sr, Th, Ti and Zn in 143 autopsied liver and kidney specimens from two Ontario communities (Kingston and Ottawa) were determined using the techniques of inductively-coupled plasma--atomic emission spectrometry, and electrothermal atomization--atomic absorption spectrometry coupled with hydride evolution (As, Se), reduction--aeration (Hg), or solvent extraction (Pb). The majority of samples came from individuals older than 50 y. In general, the data for the various elements were independent of age or sex but showed some dependence on location for elements such as Cu, Fe, K, Mg, Mn, Na, P, Se and Zn. Despite these differences the elemental values of the liver and kidney samples from both the communities were within the normal range.

Adolescent↗
PubMed1984

Arsenic in Nova Scotian groundwater.

The concentration of total soluble inorganic arsenic (i.e. arsenate plus arsenite) was measured in duplicate well water samples of 94 residents in Halifax County, N.S. An ammonium pyrrolidinedithiocarbamate-methyl isobutyl ketone graphite-furnace atomic absorption spectrophotometric procedure and also an automated hydride-evolution electrothermal-atomisation atomic-absorption spectrophotometric method were used to monitor the arsenic level in the ground water supplies. Of the 94 samples analyzed, 66 samples (70%) exceeded the Canadian maximum acceptable drinking water guideline of 50 ng As/ml.

Arsenic↗
PubMed1983

Blood levels of cadmium, copper, lead and zinc in children in a British Columbia community.

The levels of Cd, Cu, Pb and Zn were measured in duplicate whole blood samples of 946 apparently normal children ranging in age from 2 years to 12 years and living in Kamloops, British Columbia, Canada. The metals were determined using atomic absorption spectrometry: graphite furnace AAS for Cd and Pb, and flame AAS for Cu and Zn. The median and extreme values expressed as milligram of metal per litre of whole blood for the total population were: Cd less than or equal to 0.0005, Cu 1.11 (0.69-1.78), Pb 0.112 (0.020-0.400), and Zn 4.30 (2.10-6.53). No significant variations were noted in the median metal values either with age or with sex. The median Cu, Pb and Zn values were within the normal range.

Air Pollutants, Occupational↗
PubMed1981

Asbestos and drinking water in Canada.

Samples of raw, treated and distributed tap water were collected from 71 municipalities across Canada and analyzed for asbestos content by transmission electron microscopy. Chrysotile asbestos was identified as the major asbestos type present in drinking water with some 5% of public water supplies containing asbestos at concentrations greater than 10 million fibres per litre. Improvement factors of up to 300 were observed for the removal of chrysotile fibres from drinking water during treatment, indicating that coagulation/filtration treatment is efficient for this purpose. In certain cases there is evidence to suggest that erosion of asbestos from pipe material is taking place. Age-standardized mortality rates for gastro-intestinal cancers were calculated for each city for the period of 1966 to 1976. Rates for the 2 localities with the highest (congruent to 10(8)/L) concentrations of asbestos fibres in treated drinking water were compared with the weighted average of the rates for the 52 localities with asbestos concentrations not significantly greater than zero. Eleven localities had intermediate concentrations of asbestos and six were too small for meaningful statistical analysis. Relatively high mortality rates were apparent amongst males in city 1 for cancer of the large intestine except rectum, and in both sexes in city 1 and males in city 2 for stomach cancer. It is felt that these findings are probably related to occupational exposure to asbestos. Further statistical analyses are required, however, before the significance of these observations can be fully assessed.

Asbestos↗
PubMedDate not supplied

The effect of container material, storage time and temperature on cadmium and lead levels in heparinized human whole blood.

The effect of container material (polycarbonate, polyethylene, polypropylene, polystyrene, borosilicate glass and Pyrex glass), storage time (0, 1, 3, 6, 13, 20, 28 and 60 days), and temperature (22 degrees C, 4 degrees C and -10 degrees C) on cadmium and lead levels in heparinized human whole blood was studied using graphite furnace atomic absorption spectrophotometry. Whole blood samples stored in polycarbonate containers at -10 degrees C did not show significant change in the concentrations of cadmium and lead up to 60 days. Also, the cadmium and lead levels remained unchanged for two weeks when the samples were stored in polyethylene and polypropylene vessels at 4 degrees C.

Blood Specimen Collection↗