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J C Neff

Publications and source records attributed to J C Neff.

26 records · Page 2Linked to original sources
PubMed1984

Use of indirect immunofluorescence in the lupus erythematosus/lichen planus overlap syndrome: an additional diagnostic clue.

The lupus erythematosus (LE)/lichen planus (LP) overlap syndrome comprises a heterogeneous group of patients who demonstrate clinical, histologic, and immunopathologic characteristics of two diseases. We report six patients with the syndrome who were evaluated by a double-layer indirect immunofluorescence (IF) technic using patient serum and autologous lesional skin as substrate followed by conjugate. This test demonstrated intense staining of the stratum granulosum in two patients, a finding previously shown to be consistent with LP. A third patient developed criteria for the diagnosis of systemic LE with corroborating direct IF findings and a negative indirect IF assay. This preliminary study provides evidence for a possible way of distinguishing LE from LP in some patients with the overlap syndrome.

Adult↗
PubMed1983

Hematological Characteristics of the BB Wistar Rat.

Complete blood counts, differential white blood cell and platelet counts were performed on male and female BB Wistar diabetic rats (BBWd), their nondiabetic siblings (BBWnd) and outbred Wistar rats of the line from which the BB Wistar rats were derived. Most of the observed changes were strain-related (those present in both BBWd and BBWnd but not in control rats) rather than diabetes-related (those in BBWd but neither BBWnd nor control rats) and therefore probably due to the inbreeding process. The BBW strain had significantly lower numbers of white cells and platelets, as well as markedly changed differential white cell counts. Differential counts showed a pattern of lymphopenia, neutrophilia, monocytosis and eosinophilia. It is possible that these white blood cell changes contribute to the increased susceptibility to infection reported for the BBW strain. No significant difference in serum immunoglobulin concentrations was found in any of these three groups of rats. There- fore, hypogammaglobutinemia cannot account for the increased susceptibility to infections, but it is not possible to rule out an abnormality in the distribution of immunoglobulin fractions as an etiological factor.

Journal Article↗
PubMed1982

Increased helper-suppressor T-cell ratio in psoriasis.

Numerous investigations have suggested an immunologic pathogenesis of psoriasis and diminished suppressor T-cell activity of psoriatic blood. Consequently, a study was undertaken to explain whether diminished suppressor cell activity was a result of quantitative alterations of the T-lymphocyte subpopulation. Twenty patients with psoriasis and 20 normal control subjects were randomly selected. Our findings demonstrated a significant decrease in the percentage of suppressor cells (T gamma), a significant elevation of helper cells (T mu), and a highly significant increase in the helper-suppressor T-cell ratio (T mu/T gamma) of psoriatic blood compared with that of normal control subjects. Our study gives further support to the possible role of immunologic factors in the pathogenesis of psoriasis.

Adult↗
PubMedDate not supplied

Immune system changes in cytapheresis donors.

In vitro measurements of several variables of the immune system were made in 21 healthy donors who had been subjected to frequent cytapheresis an a group of whole blood donor controls matched for age and sex. Significant changes noted in the apheresis donors compared to controls included a 23 percent lower mean absolute lymphocyte count (p less than .01), a 25 percent lower mean T cell count (p less than .01), and a 46 percent lower mean B cell count (p less than .001). Serum protein changes included a 27 percent lower mean gamma globulin level (p less than .01), and 14 percent lower mean IgG level (p less than .05) in the apheresis donors when compared to the control group. The possible implications of these findings are discussed, and we suggest that donors undergoing multiple cytapheresis procedures be closely monitored to determine the safe donation frequency.

B-Lymphocytes↗