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Biomedical subjects

J C Normand

Publications and source records attributed to J C Normand.

10 recordsLinked to original sources
PubMed2000

[Chemical-induced cancers].

Most chemical carcinogenic agents are industrial. About 4% of all cancers have an occupational origin, but the percentage is higher in exposed populations. Evidence of carcinogenicity is provided by epidemiological studies, animal experiments and other biological sources like experimental mutagenesis. The IARC (International Agency for Research on Cancer) classification and the European Union classification of carcinogenic agents for humans are useful for prevention and regulation. Some cancers are classified as occupational diseases but only a few persons receive compensation given the difficulties of aetiologic diagnosis and the frequent absence of declaration.

Animals↗
PubMed1989

Evaluation of the subacute nephrotoxicity of cyclohexane and other industrial solvents in the female Sprague-Dawley rat.

The subacute nephrotoxicity of more than 20 industrial solvents has been compared in female Sprague-Dawley rats. The animals were given 5 i.p. injections of the solvents per week for 2 weeks at doses ranging from 1/20 to 1/5 of the i.p. or oral LD50 and the urinary excretion of N-acetyl-beta-D-glucosaminidase, beta 2-microglobulin and albumin was determined. Under these experimental conditions, two solvents, cyclohexane and styrene, were found to cause some tubular injury as evidenced by a statistically significant increase of beta 2-microglobulinuria. At the same dose, styrene was more tubulotoxic than cyclohexane but the opposite was observed when the solvents were administered proportionally to their LD50. The increased beta 2-microglobulinuria caused by cyclohexane was both time- and dose-dependent. It was not accompanied by changes in the glomerular filtration rate and the renal plasma flow, but at the highest dose (1.5 g/kg) the renal concentrating ability was depressed. These renal tubular effects can most likely be ascribed to cyclohexanol, the main metabolite of cyclohexane. As cyclohexane is a widely used industrial solvent with a relatively high threshold limit value (TWA-TLV: 300 ppm) it might represent an underestimated risk for the renal function of exposed populations.

Albuminuria↗
PubMed1987

[Quality of life and resumption of social life after heart transplantation].

An enquiry by means of a questionnaire was conducted among 48 patients who had received a heart transplant, in order to evaluate their quality of life and their reinsertion into the french society. Health status, physical capacities, daily social and occupational activities and degree of satisfaction are analyzed. Eighty per cent of the patients considered themselves in excellent or good health; their Karnofsky's index, which globally assesses functional capacities, was 1.6, i.e. close to the normal value of 1 and to the results obtained in heart transplant recipients in the USA and in kidney transplant recipients; 61% of non-retired patients had resumed professional or learning activities. There were little changes in leisure activities. Matrimonial happiness was high, although sexual satisfaction was less complete than normally. Ninety-three per cent were satisfied with their life after transplantation.

Activities of Daily Living↗
PubMed1982

[Contribution of lumbar puncture to the diagnosis of cephalalgia].

The authors have reviewed the records of 50 patients hospitalized for treatment of isolated cephalalgia and in whom lumbar puncture was the only investigatory procedure that initially provided some information. In 12 cases, CSF abnormalities reflected a progressive tumoral, vascular or inflammatory intracerebral lesion undetectable by the usual methods (fundus oculi, radiography of the skull, EEG), or by less common examinations (arteriography, scintiscans, CT scans). In 12 other cases, lumbar puncture provided evidence of a minimal meningeal inflammatory process. In 26 cases, the only biochemical change was an excess of CSF proteins which in 7 cases developed in a dome-shaped curve suggesting an independent disease, the significance of which is discussed.

Adult↗