PubMed HealthSearch

Biomedical subjects

J C Orlando

Publications and source records attributed to J C Orlando.

15 recordsLinked to original sources

Self-reports in chronic schizophrenic patients with primary negative symptoms: preliminary results.

The Frankfurt well-being scale (FBS), an instrument for evaluating the global inner state in schizophrenic patients, was used in a pilot study with 26 chronic schizophrenic inpatients simultaneously with the Munich version of the Andreasen scale (SANS). 11 of 26 patients were able to complete the FBS questions. These patients had weaker negative symptomatology (SANS total score) and the difference was highly significant (p less than 0.01) for the score "alogia". The major goal of the investigation was to contribute to the identification of those subgroups of schizophrenic patients who are not capable of filling in a self-report questionnaire. The results suggest that self-reports of actual mood in chronic schizophrenic patients are possible only in a subgroup of patients with no more than moderate primary negative symptoms, particularly those with a low alogia score. Further efforts to evaluate the subjective well-being of chronic patients differing in severity of negative symptoms complexes, could improve methods for evaluating the effect of psychotropic drugs.

Chronic Disease

The immunobiology of basal cell carcinoma: an in situ monoclonal antibody study.

A semi-quantitative, immunoperoxidase monoclonal antibody technique was used to study the mononuclear cells surrounding 32 basal cell carcinoma specimens from 30 patients. Tumours were analysed in subgroups based on recurrence, size and ulceration. T cell counts were high (greater than 3 out of 4) for all groups while T helper/inducer and T suppressor/cytotoxic cell counts were equal (approx. 2). Macrophage counts were low for all groups, about I X 2, while B cell and Ia positive cell counts were high (greater than 3). T/B cell and T helper/suppressor cell ratios approached one for the tumours as a whole as well as the sub-groups. The relative importance and contribution of cell mediated vs. humoral immunity in keeping basal cell carcinomas in check is discussed.

Adult

Impairment of thymus-derived lymphoid cell function in patients with basal cell carcinoma.

The host-tumor relationships in 34 patients with basal cell carcinoma was investigated by characterizing thymus-derived (T) and bone marrow-derived (B) lymphoid subpopulations in the blood by cell surface markers and lymphoid function in vitro by proliferative responses to mitogenic and antigenic stimulation. Results were correlated with tumor stage. In patients with tumor present, the data demonstrate significantly (P less than .02) decreased responsiveness of T cells to the lectin mitogens phytohemagglutinin and concanavalin A, and further demonstrate significantly decreased responsiveness of T cells to antigens (P less than .001 for Candida antigen, P less than .05 for Staphylococcal filtrate and Streptococcal varidase). In patients who were grossly disease free after resection of tumors, there was no significant difference in these responses from normal. These results document, for the first time, impaired T-cell function in patients with basal cell carcinoma and suggest that the functional impairment is tumor induced.

B-Lymphocytes

Silicone elastomer sheeting in the development of pedicle flaps.

A "delay" of a pedicle flap stimulates improvement in the flap circulation, probably through partial ischemia. The degree of stimulation prsent at any given time is inversely proportional to the length of time that has passed after the delay because progressive revascularization across the delay lines reduces the ischemis stimulus. This revascularization can ve prevented by placing silicone elastomers (Silastic) sheeting between the flap and its bed.

Animals

The superomedial dermal pedicle for nipple transposition.

A new method for nipple transposition employing a superomedial dermal pedicle is described for use in reduction mammaplasty and dermal mastopexy. The advantages include superior mobility, viability, sensation and normal appearing nipples and areolae.

Breast