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Biomedical subjects

J C Page

Publications and source records attributed to J C Page.

At least 19 recordsLinked to original sources
PubMed1998

Foot and ankle injuries related to rock climbing. The role of footwear.

Interest in rock climbing has grown dramatically over the past decade. Although considerable research has been conducted on upper-extremity injuries sustained during rock climbing, there has been no comprehensive evaluation of lower-extremity injuries and related biomechanics. The authors performed a retrospective investigation of rock-climbing injuries using a survey of 104 active rock climbers of varying levels of expertise. The results show that 81% of the respondents have suffered acute or chronic pain or associated pathology in the foot or ankle during or after climbing. The authors propose that this morbidity has biomechanical etiologies related to the common practice among rock climbers of wearing climbing shoes that are smaller than their street shoes.

Adolescent↗
PubMed1997

Torsion of the tendon of peroneus brevis.

The authors present a previously undescribed torsion located within the tendon of peroneus brevis. The musculotendinous unit of peroneus brevis was isolated from 46 lower extremities of cadavers. A goniometer was constructed and utilized to quantify the degree of torsion located within each peroneus brevis tendon. Torsion was present in all 46 cadaver specimens, with a mean of 38.5 degrees and a range of 26 degrees to 56 degrees. The regional anatomy and biomechanical functions of peroneus brevis are discussed, and proposed bases for the embryologic origins and functional significance of the torsion are presented.

Adult↗
PubMed1997

Management of painful diabetic neuropathy. A treatment algorithm.

Peripheral neuropathy manifests as a painful syndrome in a significant number of individuals suffering from diabetes mellitus. Painful diabetic neuropathy may interfere with sleep, work, and activities of daily living. Patients and practitioners alike often view this challenging disorder as incurable. A broad spectrum of therapeutic alternatives and physiologic approaches to this complex clinical problem are available. Careful assessment and a rational approach based on the nature and location of pain will lead to success. The authors review the etiology, clinical presentation, and diagnosis of diabetic peripheral neuropathy. Available therapeutic alternatives are emphasized and an original treatment algorithm is presented.

Algorithms↗
PubMed1996

Functional significance of torsion of the tendon of tibialis posterior.

The authors describe the anatomical necessity and functional significance of torsion of the tendon of tibialis posterior. A wooden model of the right lower extremity has been constructed which includes representations of the ankle, subtalar, and oblique midtarsal joints. The model is used to show that the presence of torsion within the tendon of tibialis posterior eliminates the need for any longitudinal slippage between individual tendon fibers during triplane movement of the joints of the lower extremity.

Ankle Joint↗
PubMed1995

Direct activation of murine peritoneal macrophages for nitric oxide production and tumor cell killing by interferon-gamma.

Interferon-gamma (IFN-gamma) is known to prime macrophages for tumor cell lysis and nitric oxide (NO) production as measured by enhanced sensitivity to lipopolysaccharide (LPS). In the present study, the ability of IFN-gamma to directly activate peritoneal macrophages from C57BL/6 and Balb/c mice for tumor cytotoxicity and NO production was evaluated. Macrophage-mediated tumor cell killing was measured by an 18 h 51Cr release assay using P815 mastocytoma cells as targets. Concurrent NO production was measured as nitrite in the supernatants of macrophage cultures. Incubation of macrophages with IFN-gamma resulted in activation of macrophages for tumor cell lysis. IFN-gamma alone also activated macrophages for NO production under identical conditions. Addition of LPS along with IFN-gamma resulted in synergism in the activation of macrophages for both cytolysis and NO production. LPS contamination of the IFN-gamma preparation was absent as evidenced by the following criteria: (1) the IFN-gamma preparation as well as the reagents used were shown to be free of LPS contamination based on LAL endotoxin tests (sensitivity 25 pg/ml), (2) the ability of IFN-gamma to activated macrophages was not abrogated by prior treatment of the cytokine with polymyxin B, whereas the effect of LPS was inhibited (70-100%) under similar conditions, (3) pretreatment of the IFN-gamma preparation with a specific endotoxin neutralizing protein did not abrogate the ability of IFN-gamma to induce macrophage activation, and (4) heat treatment of solutions containing IFN-gamma alone or IFN-gamma+LPS abolished only the effect of IFN-gamma, not that of LPS.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1995

Torsion of the tendon of tibialis posterior.

The authors present a previously undescribed torsion located within the tendon of tibialis posterior. The musculotendinous unit of tibialis posterior was isolated from 17 lower extremities of cadavers. A small goniometer was constructed and used to quantify the degree of torsion located within each tibialis posterior tendon. Torsion was present in all 17 cadaver specimens, with a mean of 47.5 degrees and a range from 21 degrees to 62 degrees. The regional anatomy and biomechanical functions of tibialis posterior are discussed, and proposed bases for the embryologic origins and functional significance of the torsion are presented.

Aged↗
PubMed1994

Medical management of the diabetic patient during podiatric surgery.

Diabetes mellitus commonly causes complications of the foot that can lead to surgery. The appropriate perioperative management of diabetic patients can reduce the morbidity and mortality associated with diabetic foot surgery and enhance wound healing. The authors review the effects of hyperglycemia, detail preoperative, intraoperative, and postoperative care, and describe anesthetic choices. An algorithm for management of hypoglycemia is offered.

Diabetic Foot↗
PubMed1994

Painful diabetic peripheral neuropathy. A stepwise approach to treatment.

The stepwise approach to the treatment of painful diabetic peripheral neuropathy allows the practitioner to use a broad spectrum of therapeutic modalities and physiologic approaches to this complicated clinical problem. The authors review the etiology and clinical presentation of diabetic neuropathy. Available therapeutic alternatives are discussed and an original stepwise algorithm is presented. Pharmacologic profiles of the most commonly used drugs are also described.

Diabetic Foot↗
PubMed1993

Intraosseous lipoma of the os calcis.

The authors present three cases of a rare calcaneal tumor, intraosseous lipoma. The differentiation of intraosseous lipoma from other benign tumors is discussed. The diagnosis and treatment are reviewed.

Adult↗
PubMed1991

Diagnosis and treatment of tinea pedis. A review and update.

Fungal foot infections are becoming an increasingly common public health problem as the population ages. New studies have shown that some of the traditional therapeutic antifungal agents have multiple actions that enable them to be more efficacious than previously thought, and more efficacious than other agents without multiple actions. In this review article, the pedal infections commonly referred to as tinea pedis, or athlete's foot, are described. The etiologic agents involved in the pathogenesis, the methodologies for proper diagnosis, and the therapeutic agents commercially available for treatment are reviewed.

Antifungal Agents↗
PubMed1991

The distal saphenous vein cutdown procedure.

Distal saphenous vein cutdown is an excellent method for intravenous access. It allows for a rapid infusion of fluids. Although the saphenous vein cutdown is not commonly performed, the podiatrist should be familiar with this procedure, as it may be necessary during an emergency situation.

Education, Medical, Continuing↗
PubMed1983

Brachymetatarsia with brachymesodactyly.

A case of brachymetatarsia with congenital absence of all middle phalanges was presented. This is believed to be the first such case reported. Many surgical options are available for the correction of microdactyly. Satisfactory surgical results were achieved via bunionectomy, the implantation of a double-stemmed prosthetic joint in the fourth metatarsophalangeal joint and osteotomy of the second metatarsal bone.

Adolescent↗