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Biomedical subjects

J C Richardi

Publications and source records attributed to J C Richardi.

5 recordsLinked to original sources
PubMed1983

Effects of acute ochratoxicosis on blood pressure and heart rate of broiler chickens.

Male broiler chickens (Hubbard X Hubbard) were placed at hatching into electrically heated batteries with feed and water available ad libitum and maintained to 3 weeks of age under continuous lighting. In Trial 1, two replicate pens of 10 broilers per replicate were fed ochratoxin A from day-old to 3 weeks of age with treatments of 0, 2.0, and 4.0 micrograms/g ochratoxin A in feed (ppm). Trial 2 was identical to Trial 1 except that when the broilers reached 3 weeks of age they were administered an additional intravenous dose of either ochratoxin A, methoxamine, or isoproterenol. Trial 3 broiler chickens were maintained on control feed until they reached 3 weeks of age at which time they were taken off of feed for 2.5 hr and then placed on either control feed or feed containing 4.0 ppm ochratoxin A, and heart rate and blood pressure were measured every half hour through 7 hr. In Trial 1, no effect of ochratoxin A was seen in any treatment on heart rate or diastolic, systolic, or mean blood pressure. However, when an intravenous dose of ochratoxin A was administered to these broilers, a significant (P less than .05) decrease in heart rate and diastolic, systolic, and mean blood pressure occurred. The severity and duration of intravenous ochratoxin A administration were significantly (P less than .05) enhanced as the level of dietary ochratoxin A increased. The response of broilers to isoproterenol was significantly (P less than .05) altered by dietary ochratoxin A, whereas the broilers responded in a predictable manner to methoxamine without significant (P less than .05) ochratoxin A treatment effects.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1981

Comparison of brachial venous and mixed blood gas tensions and pH values in the chicken.

Differences in blood gas tensions and pH between brachial venous blood (BVB) and mixed venous blood obtained from the pulmonary artery (PAB) were compared in anesthetized male White Leghorn chickens to determine if BVB as obtained in routine venipuncture cold be used to estimate mixed venous values of pO2, pCO2, and pH. When paired samples were compared over the range of 25 to 68 mm Hg, brachial pO2 was 5.7 mm Hg higher (P less than .001) than PAB pO2. Brachial pCO2 was 4.25 mm Hg higher (P less than .001) than PAB pCO2 over the range of 17 to 56 mm Hg. Brachial pH was .066 units lower (p less than .001) than comparable values for PAB over the range of 7.2-7.6 pH units. Regression equations are given for estimating mixed venous blood gas tensions and pH values from blood samples taken from the brachial vein.

Animals↗
PubMed1980

Long-term effects of diazepam on plasma lipids and atheroma in roosters fed in atherogenic diet.

Long-term effects of diazepam on plasma lipids and atheroma in roosters fed an atherogenic diet have been studied. Our data indicate that long-term administration (8 months) of diazepam (Valium) 0.2 mg/kg orally lowered the plasma cholesterol level when compared to the atherogenic group, but this was not statistically significant (P greater than 0.05). However, at the dose of 0.4 mg/kg of Valium the plasma cholesterol was significantly lowered when compared to the controls on an atherogenic diet (P less than 0.05). Both doses of Valium significantly decreased the incidence and severity of lesions on the endothelial surface of the aorta and coronary artery in roosters fed an atherogenic diet. No changes in plasma triglyceride values were noted. Administration of 0.4 mg/kg of Valium to birds receiving the atherogenic diet produced a small but significant increase of mean, systolic and diastolic blood pressures as compared to the birds receiving an atherogenic diet but no Valium. A similar increase in blood pressure was also noted in the control group on plain mash diet receiving 0.2 mg/kg of Valium. Microscopic examination of the coronary arteries showed that birds on an atherogenic regimen receiving Valium had less atherosclerosis than those not receiving Valium.

Animals↗