PubMed Health⌕ Search

Biomedical subjects

J C Sage

Publications and source records attributed to J C Sage.

14 recordsLinked to original sources
PubMed2006

Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study.

BACKGROUND: The aim of this study was to assess the non-inferiority of an oral contraceptive (OC)-pretreated cetrorelix regimen and a buserelin regimen in IVF/ICSI patients treated with r-hFSH in terms of total number of oocytes retrieved. METHODS: Multicentre, randomized study. One hundred and eighty two patients were randomized to receive cetrorelix with OC pretreatment (n = 91) or to receive buserelin (n = 91). The cetrorelix group started with daily OCs on cycle day 5 and continued for 21-28 days. Cetrorelix (0.25 mg) was given daily from stimulation day 6 up to and including the day of r-hCG administration. The buserelin group started with buserelin (500 microg/day) for at least 10 days until down-regulation was achieved, after which the dose was reduced to daily 200 microg up to and including the day of r-hCG administration. r-hFSH was started in both groups on a Friday, in the cetrorelix group 5 days after the last OC pill intake. Both regimens were followed by a standard IVF or ICSI procedure. The primary efficacy endpoint was the number of oocytes retrieved per patient. RESULTS: Number of oocytes, cancellation rates, r-hFSH requirements, number of oocyte retrievals during the weekend or public holiday and number of pregnancies were similar in both groups. Both treatment regimens were well tolerated. CONCLUSIONS: Cetrorelix pretreated with OCs resulted in similar number of oocytes retrieved compared with a long buserelin protocol. Both regimens were well tolerated and allowed scheduling of the oocyte retrieval, with only small number of retrievals falling on a weekend or public holiday.

Adolescent↗
PubMed1986

Value of cytoprognostic classification in breast carcinomas.

Two hundred and four cases of breast carcinoma were classified according to cytological features, and these were related to prognosis. A disease free interval of seven years was 95% for patients with grade I, 70% for those with grade II, and 45% for those with grade III tumours. The risk of recurrence was also related to tumour size and the presence or absence of steroid receptors in the tumour. Cytological classification of breast carcinoma based on fine needle aspiration provides valuable information concerning the prognosis of patients, which is relevant to their clinical management.

Breast Neoplasms↗
PubMed1983

Tamoxifen-induced fluorescence as a marker of human breast tumor cell responsiveness to hormonal manipulations: correlation with progesterone receptor content and ultrastructural alterations.

The fluorescent binding of tamoxifen to eosin is used on Papanicolaou-stained smears as a marker of cell responsiveness to the antiestrogen molecule. Forty-two cases of human breast carcinomas were submitted to tamoxifen treatment between first diagnosis and surgery (4 to 30 days). Tamoxifen-induced fluorescence is observed in 17 of 42 cases (40%). There is a highly significant correlation between progesterone receptor content of the tumor and cellular fluorescence (0.01 greater than p greater than 0.001). Ultrastructural changes of such tumors (820 cells observed in 28 treated patients and 840 cells in 32 untreated controls) are observed in 42% of treated cells versus 10% of untreated cells. These ultrastructural alterations can be significantly correlated with cellular fluorescence induced by tamoxifen treatment and with progesterone receptor content of human breast cancers. These data suggest that a short pretreatment with tamoxifen before surgery can give useful additional information at the biochemical, cytochemical, and ultrastructural levels regarding cell responsiveness to hormonal manipulation.

Breast Neoplasms↗
PubMed1982

[Cytologic grade, a prognostic factor in breast cancer].

Fine needle aspirations of breast carcinomas, submitted to a hypochromic Papanicolaou staining procedure, provides useful prognostic data. Three grades of increasing severity were used as a classification. An homogeneous group of 189 patients submitted to similar therapeutic management has been analyzed: 15.3/1 000 patients/months of those classified in grade III, versus 5.2 in grade II and 2 in grade I have had a worsening outcome within 1 to 5 years. The correlation of the cytoprognostic classification with TNM classification and lymph node involvement is significant. Moreover grade III points at patients with high metastatic potential: 27 per cent of stage I, 18 per cent without lymph nodes involvement and 23 per cent with less than 3 lymph nodes involved will develop recurrence within 5 years. The absence of steroid receptors confirms the poor prognosis of grade III.

Biopsy, Needle↗
PubMed1981

[Tamoxifen induced fluorescence as a marker of hormone receptors: cytological study of fine needle biopsy of malignant breast tumors in treated women].

Tamoxifen-induced fluorescence was used as a marker of hormone receptors in breast tumor cytology. Patients receiving Tamoxifen were compared to patients without such a therapy. Only those receiving this treatment showed fluorescence in their malignant cells. Moreover, in this group, such a fluorescence was noticed only in those patients with hormonal receptors in their tumor cells and not in the patients without estrogen and progesterone receptors. Such a technique seems to be a good method for predicting response to hormonal therapy.

Biopsy, Needle↗
PubMed1979

[Cytoprognosis in the pretherapeutic assessment of carcinoma of the breast. 192 cases. (author's transl)].

A cytologic grading method of fine needle aspiration smears has been applied to 192 cases of breast carcinoma. Grade I defines well differenciated carcinoma, grade II pleioporphic tumor cells, grade III anaplastic carcinoma. Special attention was given to the unfavorable forms of tumors (grade III). The cytologic grading was correlated with the NMT clinical classification, with the notion of acute exacerbation and with axillary nodes involvement. The correlation of grading with the clinical course of the disease was evaluated after a twelve months follow up. In 4% of patients classified in grade I, 8% of grade II and 58% of grade III, metastases, local recurrence or death had occurred within one year. The contribution of grading to the identification of fast growing tumors is discussed.

Breast Neoplasms↗