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Biomedical subjects

J C Sarles

Publications and source records attributed to J C Sarles.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Treatment of low rectovaginal fistula by pulling down a rectal mucosal curtain].

The most delicate stage in the repair of low rectovaginal fistulae is closure of the rectal opening. To the numerous and complex procedures proposed, the authors oppose a simple technique which consists of separating the rectal mucosa, which can then be pulled down like a curtain to effectively and completely obturate the opening without attending to the muscular breach. This technique has been successfully used in 9 cases of low recto-vaginal fistulae of obstetrical or infectious origin.

Female↗
PubMed1983

Effect of prostaglandins E1, E2, and F2 alpha on the electric activity of the sphincter of Oddi in living rabbit.

The effect of prostaglandins (PGs), i.e. PGE1, PGE2 and PGF2 alpha (0.5-32 micrograms/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PGs were injected intravenously as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were also studied at the same time. PGE1 strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF2 alpha. Both PGE1 and PGF2 alpha showed a dose-response curve of Michaelis-Menten type. Unexpectedly PGE2 increased at first then decreased electrical activity but not significantly. These effects appeared very early after intravenous injection and were evident with low doses.

Action Potentials↗
PubMed1982

Surgical treatment of chronic pancreatitis. Report of 134 cases treated by resection or drainage.

One hundred thirty-four patients (123 men and 11 women) were operated on for chronic pancreatitis (69 pancreaticojejunostomies, 20 cytopancreaticojejunostomies, 22 left pancreatectomies, and 23 Whipple operations). Half of these patients were followed up for 5 years or more. Four patients died from cancer of the pancreas. The operative mortality rate was 4.2 percent after anastomosis, 13.5 percent after pancreatectomy, and 8.7 percent after a Whipple operation. Relief of pain was the main aim of operation. The rate of good results after pancreaticojejunostomy (85 percent) was higher than after resection (71 percent after right pancreatectomy or Whipple operation and 66.6 percent after left pancreatectomy). The mortality rate after 5 years 26 percent after anastomosis, 30 percent after Whipple operation, and 45 percent after left pancreatectomy. Alcoholic intake did not appear to influence the operative result but improved the quality of life of the patient. Postoperative complications are more common and more serious after resection than after anastomosis. If dilated, the common bile duct must be drained as well as the pancreatic duct after anastomosis. Whenever the pancreatic duct is dilated more than 8 mm it must be drained rather than resected.

Adult↗
PubMed1982

[Primary odditis. Clinical features, therapy, and possible pathogenesis (author's transl)].

Primary odditis, a rare affection, was observed in 28 patients (15 women and 13 men) with a mean age of 56.4 years. Epigastric or right hypochondrial pain was the presenting symptom in 13 cases, while in 13 others the onset was heralded by jaundice, either of a chronic nature (2 cases) or of the pseudo-lithiasic type (11 cases). The pancreatic form is much less frequent (2 cases). Radiological and histological findings are compared with those described in the published literature. All patients demonstrated a specific psychosomatic profile. Primary odditis can be reproduced experimentally in dogs by chronic irritation of the right splanchnic nerve, this acting on a nerve circuit which includes the right splanchnic and left vagus nerves. It is suggested that such lesions are secondary to a "nervous irritation" (Reilly's phenomenon). Treatment of primary odditis is by surgery only, sphincterectomy giving the best results, though choledochoduodenal anastomosis is also effective in elderly patients.

Adult↗
PubMed1981

Action of gastrointestinal hormones on the myoelectric activity of the sphincter of Oddi in living rabbit.

The aim of this work was to compare the action of gastrointestinal (GI) hormones on the myoelectrical activity of the sphincter of Oddi. Using an experimental design previously described, we studied the electrical activity of the sphincter of Oddi and compared the percentage variation in the number of spikes before and after injection of hormones. Increasing doses of the following hormones were injected i.v. at random: CCK, OP-CCK, caerulein, bombesin, gastrin, secretin and glucagon. CCK and caerulein (as previously found), and also bombesin, OP-CCK and gastrin increased the spikes activity of the sphincter of Oddi. Secretin had no effect and glucagon decreased this activity. There was no tachyphylaxis, but a good dose-effect relationship for each hormone. Compared on a molar basis caerulein is 8 times more effective than CCK and OP-CCK which in turn are more potent than bombesin. Gastrin acts only at pharmacological doses.

Ampulla of Vater↗
PubMed1981

In vivo effect of 13 Leu motilin on the electric activity of the rabbit sphincter of Oddi.

Myoelectrical activity of the sphincter of Oddi was studied in 15 anaesthetized and laparotomized male rabbits, before and after injection of various doses of 13 Leucine Motilin (13 L Motilin), a biological and structural analogue of natural motilin. It can be concluded that 13 L Motilin provoked an increase of the sphincter of Oddi spike activity with doses ranging from 0.1 to 1.6 x 10(-6) g/kg. This effect had begun one minute after the injection, reached its maximum at the second minute and lasted for fifteen minutes. The action of 13 L Motilin is dose-related between 0.2 and 0.6 x 10(-6).

Ampulla of Vater↗
PubMed1981

[Glucagonoma without diabetes: a case report (author's transl)].

A further case of glucagonoma is reported, unusual features being the prolonged duration of cutaneous manifestations (12 years), and the absence of diabetes. Possible explanations for this anomaly: compensatory insulin or somatostatin secretion, production of a non functional glucagon, or low levels of circulating glucagon, are envisaged but without a formal response.

Adenoma, Islet Cell↗
PubMed1980

Arterial dysplasia of the colonic arteries: a rare cause of hemoperitoneum.

A case is reported of hemoperitoneum in a 66-year-old man. Abdominal angiography showed alternate narrowed and dilated segments in all the colonic arteries. A total colectomy was performed. Pathologic examination of the arteries showed, in the media and intima, some lesions of dysplastic character, which leads to a diagnosis of arterial dysplasia.

Aged↗