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J C Steele

Publications and source records attributed to J C Steele.

70 records · Page 4Linked to original sources
PubMed1970

Recurrent multiple cranial nerve palsies: a distinctive syndrome of cranial polyneuropathy.

This report of 14 Thai patients describes the clinical features of a symptom-complex we have termed recurrent multiple cranial nerve palsies. While the disorder is common in South Eastern Asia, patients suffering similar symptoms have been seen in Europe and America. Characteristically, a long prodromal headache precedes the abrupt onset of multiple cranial nerve palsies affecting predominantly, although not exclusively, the oculomotor and facial nerves. Symptoms are self-limited and steroid therapy hastens recovery in most cases. Recurrence after many months or years is not uncommon and different cranial nerves may then be affected. Wider neurological involvement seems not to occur. Although the erythrocyte sedimentation rate is frequently elevated there is no other evidence of co-existing systemic disease. The single necropsy study thus far reported indicates that the pathogenesis of the syndrome is granulomatous inflammation of the meninges (dura), adjacent to, and involving the perineurium of cranial nerves. It is uncertain whether this inflammation is a response to a single agent, as yet unidentified, or a focal and selective hypersensitivity reaction of connective tissue to a number of different factors. As a clinical entity the syndrome is distinctive, international, and deserving of wide recognition.

Adolescent↗
PubMedDate not supplied

On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam.

In diseases such as the Parkinson dementia complex of Guam (PDC) or Alzheimer's disease, susceptible neurons develop intracellular tangles (iNFTs) and then die, leaving behind extracellular tangles (eNFTs). We performed counts of healthy neurons, iNFTs, and eNFTs in the hippocampus of Guamanian Chamorros who were neurologically normal or who suffered from PDC. The total of surviving and dead neurons in the CA4 region was remarkably constant from case to case, indicating that eNFTs are not phagocytosed. Since cases of recent PDC showed only marginal tangle formation in CA4, we concluded that tangle development in CA4 commenced close to the onset of the disease. Based on this assumption, as well as the further assumption that the average rate of tangle development and the average lifetime of a tangled neuron do not alter as the disease progresses, we derived equations to determine the average lifetime of tangled neurons. The results varied from 0.13 years for the most rapidly progressing case to 7.98 years for the most slowly developing case. The average for 8 cases was 2.51 years.

Adult↗
PubMedDate not supplied

A multicenter comparative study of the in vitro activity of fleroxacin and other antimicrobial agents.

The in vitro activity of fleroxacin was determined by broth microdilution against 2,079 recent bacterial isolates and compared to the activities of ciprofloxacin, ofloxacin, lomefloxacin, cefaclor, cefuroxime, cefixime, ceftriaxone, amoxicillin/clavulanate, trimethoprim/sulfamethoxazole (TMP-SMX), and, as appropriate, erythromycin and oxacillin. Most Enterobacteriaceae were inhibited by the quinolones at a concentration of < or = 1 microgram/ml; MIC90s of fleroxacin, ciprofloxacin, ofloxacin, and lomefloxacin were 0.25, 0.5, 1 and 1 micrograms/ml, respectively. Fleroxacin was 2-fold more active than ciprofloxacin against Providencia stuartii and Serratia marcescens. Aside from the quinolones, ceftriaxone and TMP-SMX were the most active antibiotics against the Enterobacteriaceae, with MIC90s of 8 and 16 micrograms/ml, respectively. Ciprofloxacin was more active against Pseudomonas aeruginosa than the other quinolones, while fleroxacin was more active against Stenotrophomonas maltophilia: 17.7, 11.2, 20.0, and 22.4% of P. aeruginosa were resistant to fleroxacin, ciprofloxacin, ofloxacin, and lomefloxacin, respectively. Moraxella catarrhalis and Haemophilus influenzae were uniformally susceptible to all antibiotics tested, as were the majority of oxacillin-susceptible staphylococci. The MIC90s of the quinolones and of the beta-lactam antibiotics for oxacillin-resistant staphylococci were 8- to 256-fold higher than for oxacillin-susceptible staphylococci. The beta-lactam antibiotics, TMP-SMX, and erythromycin were more active than the quinolones against streptococci; all antibiotics were poorly active against enterococci. Fleroxacin is active against a broad range of gram-negative bacilli and against oxacillin-susceptible staphylococci and should prove useful for such infections. However, its use cannot be recommended for infections due to oxacillin-resistant staphylococci, streptococci, or enterococci.

Anti-Bacterial Agents↗