Biomedical subjects
Publications and source records attributed to J C Stuart.
Pseudomonas aeruginosa produces proteolytic enzymes capable of causing severe corneal degradation. In this study we tested aprotinin, a broad-spectrum protease inhibitor, on rabbit corneas infected with P. aeruginosa to determine whether any benefit could be derived. Corneas treated with aprotinin and tobramycin topically and subconjunctivally were not clinically better than corneas treated with tobramycin alone.
We prospectively evaluated 20 eyes of 19 consecutive patients to determine the nature of temporal changes in posterior capsulotomy size, shape, and contour six weeks following neodymium:YAG laser posterior capsular disruption. Mean capsulotomy area increased by 32% (range 0 to 134%, P less than .05, Student t-test), although mean capsulotomy perimeter did not change appreciably. Capsular enlargement tended toward sphericity over time, with smoothing of edge contour from capsular tag retraction. Remodeling of opening size, shape, and contour was most likely to occur with preoperative evidence of capsular traction, and highly irregular capsulotomy borders immediately post-discission.
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Monensin, fed in excess of 200 ppm caused mortality in Triple 5 and Triple 6 turkeys aged 25 weeks old and over. Mortality commenced three to four days after administering feed containing monensin and ceased three to five days after it was removed. This concentration of drug did not have any detectable adverse effects on Triple 5 turkeys fed from day old, four weeks old, or 11 weeks old for periods of two weeks.
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Corneal deposits of granular dystrophy were studies in six corneas from five patients. Two additional corneas from two patients with lattice dystrophy were used for comparison. The diagnoses were confirmed by light and electron microscopy. Three types of ultrastructural features were distinguished in the electron-dense rod-shaped deposits of granular dystrophy, i.e., Type 1 with homogenous structure, Type 2 with fibrillar constituents, and Type 3 with a moth-eaten or sponge-like appearance. In polarization microscopy of Congo-red stained sections, the Type 2 tended to show an increased birefringence without green dichroism, while the other types were less birefringent than the stroma. Three different components were found immediately around the deposits, i.e., 1. normal collagen fibrils, 2. finely filamentous substance, and 3. areas of thin fibrils (70-100 A in diameter). While the second component appeared non-specific, the third component was found only in two corneas, superimposed on the lesions of granular dystrophy, and showed light and electron microscopic characteristics of the lesions of amyloid as well as of lattice dystrophy.
Four full-thickness corneal buttons and tissue from one lamellar keratoplasty, derived from four patients with granular corneal dystrophy recurring in previously transplanted corneas, were studied by light and transmission electron microscopy. Fibrous tissue without vascularization was present between the epithelium and Bowman's membrane and contained deposits characteristic of granular dystrophy in both light and electron microscopy. The recurrence of dystrophy in the normal donor cornea is the result of infiltration of the grafted cornea by host invasion. The donor stroma is spared.
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