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J C Trindade

Publications and source records attributed to J C Trindade.

11 recordsLinked to original sources
PubMed1990

Influence of nephrectomy on the growth of a murine Wilms tumor: a study using parabiotic rats.

It has been reported that unilateral nephrectomy causes acceleration of the growth of a Wistar/Furth rat Wilms tumor. We studied this phenomenon in parabiotic rats by measuring tumor growth after either sham nephrectomy, or excision of 1, 2 or 3 kidneys. We observed no stimulation of tumor growth in the experimental groups. Renal function was significantly decreased after removal of 2 or 3 kidneys. Serum creatinine levels were significantly different between right and left members of parabiotic pairs in these 2 groups. The effect of unilateral and bilateral nephrectomy on tumor growth in single rats also was examined. In these rats progressive increases in tumor growth were observed after unilateral and bilateral nephrectomy. Our inability to demonstrate a tumor-stimulating factor in the parabiotic model may be due partly to incomplete sharing of humoral factors between parabionts. Serum transfer studies in vitro may prove more fruitful in demonstrating such a factor.

Animals↗
PubMed1985

Cyclophosphamide and inhibition of renal compensatory hypertrophy.

The objective of the present study was to determine whether cyclophosphamide inhibits nephrectomy-induced compensatory renal hypertrophy directly or indirectly owing to the reduced food intake caused by the drug. We measured kidney weight and renal water, protein, deoxyribonucleic acid (DNA), and ribonucleic acid (RNA) content and the renal RNA/DNA ratio in 72 rats distributed into groups as follows: left nephrectomized/cyclophosphamide-treated rats; left nephrectomized/saline treated rats; left nephrectomized rats submitted to food restriction and treated with saline; and left sham-nephrectomized rats treated with saline. An additional group of 12 rats was studied to obtain the initial values of the parameters. The parameters were also measured 1, 2 and 3 weeks after left nephrectomy or sham-operation. Cyclophosphamide was given once a week intraperitoneally at the dosage of 60 mg/kg body weight in saline. Corresponding volumes of saline were given to control animals. At the end of the 1st week all nephrectomized groups of rats showed some degree of renal compensatory growth. However, no significant differences in kidney weight, protein or RNA content were detected between controls, cyclophosphamide-treated rats, and animals submitted to food restriction at the end of the 2nd and 3rd week. We conclude that cyclophosphamide inhibits but does not abolish compensatory renal hypertrophy after uninephrectomy in the young rat and this inhibition is mediated primarily through the reduced food intake caused by the drug.

Adaptation, Physiological↗
PubMed1971

[Trichobezoars].

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Adult↗
PubMedDate not supplied

Latero-terminal neurorrhaphy without removal of the epineural sheath. Experimental study in rats.

Termino-lateral neurorrhaphies have been used up to the beginning of this century. After this period, they have no longer been reported. We tested the efficacy of a new type of latero-terminal neurorrhaphy and evaluated the role of the epineural sheath. A group of 10 rats had the fibular nerve sectioned and the distal ending was sutured to the lateral face of the tibial nerve without removing the epineurium. All experiments were made on the right side, the left one remaining untouched in half of the animals of each group. The other half were denervated by sectioning and inverting the endings of the fibular nerves. In this way, tibial cranial muscles were either normal or denervated in the left side and reinnervated through latero-terminal neurorrhaphy in the right side. After 7.7 months, the animals were subjected to electrophysiological tests, sacrificed, and the nerves and muscles were taken for histological exams. A response of the tibial cranial muscle was obtained in 75% of the animals. The distal ending of the fibular nerve showed an average of 498 nerve fibers. The average areas of the reinnervated tibial cranial muscles were (mu 2):841.30 for M2n and 1798.33 for M2d. We concluded that the termino-lateral neurorrhaphy was functional, conducting electrical stimuli and allowing the passage of axons from the lateral surface of a healthy nerve, to reconstitute the distal segment of a sectioned nerve. The presence of the epineurium was no impediment to axonal regeneration or to the passage of electrical stimuli.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMedDate not supplied

Serial study of the complement fractions C3, C4 and C3PA in allergic children.

The C3, C4 and C3PA complement fractions were dosed by radial immunodiffusion in the serum of 25 children with ages from 4 to 9 years in a non symptomatic period comprehending 10 atopic asthmas (40,0% of the cases) 8 non atopic asthmas (32.0%) and 7 urticarias (28,0%). The quantitative dosage of the studied fractions was carried out in a serial form 7, 14, 30 and 45 days after the first determination, what made a total of 116 dosages of C3, 112 of C4 and 114 of C3PA. Globally, no differences were verified in the averages and standard deviations of the complement fractions studied in the various pathological situations considered. The complement anomaly more frequently observed was the C4 increase in 37,8% of the assays in patients with atopic asthma, 16,2% of the assays in patients with non-atopic asthma and in 33,3% of the assays in urticaria cases. The other complement fractions studied showed inconstant variations in some cases. The serial study demonstrated in the same patient, variations larger than 2 standard deviations in 25,8% of the assays for C3, 25,0% for C4 and 27,2% for C3PA, what may possibly indicate the great instability of the complement system which depends on a function, consumption or activation and synthesis relation, having to be taken into consideration in those assays comprehending the quantitative study of the seric complement fractions.

Asthma↗