Biomedical subjects

J C Tucker

Publications and source records attributed to J C Tucker.

20 records · Page 2Linked to original sources

PubMedDate not supplied

Lorazepam treatment in the neonatal rat alters submissive behavior in adulthood.

Male hooded Lister rats were cross-fostered at birth (day 0) and reared in litters of eight. Within each litter, one pup was treated with each dose of lorazepam (0.25 or 1.25 mg/kg) and one was treated with the placebo vehicle. The pups received daily subcutaneous injections between postnatal days 7 and 21 inclusive. Starting on day 70 the animals were subjected to four tests of exploratory and social behavior: Open Field, Holeboard, Social Interaction and Home-Cage Aggression. The drug-treated animals showed an increase in submissive behavior, particularly when intruding into another animal's territory, but only minimal changes in their performance in the other three tests.

Aggression↗

PubMedDate not supplied

Neonatal clomipramine treatment in the rat does not affect social, sexual and exploratory behaviors in adulthood.

The potential ability of the tricyclic anti-depressant clomipramine to cause an increase in anxiety in adult animals following neonatal treatment with the drug has been investigated; no such anxiogenic actions were found in the social interaction test. Furthermore, the behavior of animals that had received the drug as pups did not differ from that of the controls in open field or holeboard tests, nor in tests of sexual behavior, aggressive and dominance behaviors or passive avoidance learning.

Aggression↗