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Biomedical subjects

J C Vangilder

Publications and source records attributed to J C Vangilder.

7 recordsLinked to original sources

Behavioural manifestations of third ventricular colloid cysts.

Three patients with third ventricular colloid cysts manifested disturbances of memory, emotion and personality in the absence of hydrocephalus. All three patients demonstrated significant improvement following removal of the tumours. The symptoms and signs associated with these neoplasms may be attributed to compression or vascular compromise of the diencephalon with disorder of major limbic system structures. Tumour removal should be undertaken in patients with symptoms even in the absence of hydrocephalus, and ventricular shunting may be inadequate as a sole therapeutic measure.

Adult

Spontaneous intracerebral hematoma in carotid-cavernous fistula. Report of three cases.

Spontaneous intracerebral hematoma associated with carotid-cavernous fistula is rare. Three new cases are presented. In each, the hemorrhage originated in the vicinity of localized intracranial venous engorgement, as demonstrated by cerebral angiography. Rupture of one or several of the distended venous channels from increased back-flow is postulated as the etiology of the intraparenchymal hematomas.

Aged

Spinal cord conduction pathway for cerebellar evoked potentials from C-fibers.

Evoked responses from saphenous nerve C fiber stimulation were identified on the ipsilateral intermediate cerebellar cortex. This late potential has a latency between 180 and 250 msec, duration 50-70 msec, and an amplitude 10-20 micro V. The potential is conducted in the ipsilateral dorsal quadrant as determined by differential section of the spinal cord. The probable pathway is assigned to the dorsal spinocerebellar tract.

Animals

The effect of antifibrinolytic therapy in experimental spinal cord trauma.

The efficacy of antifibrinolytic therapy with epsilon aminocaproic acid (EACA) in experimental spinal cord injury is assessed by use of a standardized trauma model at both nonparaplegic and paraplegic trauma doses. Evaluation of neurologic parameters, cortical evoked response and histopathology of the injured spinal cord demonstrated that within the contusion range studied, EACA has no significant therapeutic effect. The ability of the animal to walk was the most reliable criterion indicative of functional recovery, and was closely paralleled by return of the cortical evoked response. Spinal cord cavitation in excess of 60% uniformly resulted in paraplegia. The data from this experiment show no evidence of a significant secondary injury occurring after spinal cord trauma that is amenable to posttraumatic antifibrinolytic therapy.

Aminocaproates