[Welcome the multicenter studies].
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Cooperative Behavior↗
Biomedical subjects
J Candell Riera
Publications and source records attributed to J Candell Riera.
[Value of Doppler-echocardiography in the prognosis and follow up of hypertrophic myocardiopathy].
INTRODUCTION AND OBJECTIVES: The aim of this study was to assess the value of Doppler-echocardiogram for the prognosis and follow up of a hospital-based series of adult patients with hypertrophic cardiomyopathy (HC). METHODS: One-hundred nineteen consecutive patients with HC (52 +/- 12 years, 60 women) were studied over a follow up period of 9.7 +/- 6.7 years. Echocardiographic evolution was analyzed in 104 patients (67 with dynamic obstruction) who had, at least, two echocardiograms performed within an interval of 3.7 +/- 3 years (1 to 7 years). RESULTS: Seven patients died during follow up and 31 patients developed severe complications (7 deaths, 15 syncopes, 4 class IV angina, 3 class IV dyspnea and 2 acute myocardial infarctions). The presence of mitral insufficiency (p = 0.001) and dynamic gradient > 50 mmHg (p = 0.02) were predictive of mortality and a left atrial index > 25 mm/m2 was predictive (p = 0.028) of severe complications. Fifteen percent of the patients without dynamic obstruction in the first Doppler-echo showed a gradient > 25 mmHg in the last echo. A greater number of patients with mitral insufficiency (80% vs 66%; p = 0.01) and an increase in its severity (p = 0.038) was observed during follow up. CONCLUSIONS: Mitral insufficiency, a dynamic gradient > 50 mmHg and a left atrial index > 25 mm/m2 are variables of a bad prognosis in adult patients with HC. An evolution to obstructive HC was observed in 15% of non obstructive HC, and a tendency to increased severity of mitral insufficiency was observed during follow up.
Cardiomyopathy, Hypertrophic↗
[Nuclear cardiology: technical bases and clinical applications].
Although the role of nuclear cardiology is currently well consolidated, the addition of new radiotracers and modern techniques makes it necessary to continuously update the requirements, equipment and clinical applications of these isotopic tests. The characteristics of the radioisotopic drugs and examinations presently used are explained in the first part of this text. In the second, the indications of them in diagnostic and prognostic evaluation of the different coronary diseases are presented.
Coronary Circulation↗
[The clinical management guidelines of the Sociedad Española de Cardiología. Nuclear cardiology: the technical bases and clinical applications].
Although the role of nuclear cardiology is currently well consolidated, the addition of new radiotracers and modern techniques prompt us to permanently update the requirements, equipment and clinical applications of these isotopic tests. Radioisotopic drugs, instrumentation and characteristics of radionuclide tests that are presently used are explained in the first part of this text. In the second part, diagnostic and prognostic indications of these tests are presented in detail.
Cardiology↗
[Quantification of myocardial ischemia in regions dependent on occluded coronary arteries in patients without previous infarction].
INTRODUCTION AND OBJECTIVES: The aim of this study is to assess myocardial ischemia in regions with no infarction dependent occluded coronary arteries. PATIENTS AND METHODS: 149 patients with proved coronary artery disease and without previous myocardial infarction were studied by 99mTc-MIBI SPECT (long protocol) and coronary angiography. The extent of the uptake reversibility was quantified in 3 regions (antero-septal, inferior and lateral) of the polar maps, assessing the percentage of each region that had a > 10% difference resulting from the rest uptake minus the stress uptake. The regions dependent on one occluded artery were compared to those dependent on non-occluded arteries. In the regions dependent on one occluded artery a comparison was also made between those which had a good collateral circulation and those which did not. RESULTS: Fifty-four out of 149 patients (36%) had at least one occluded coronary artery (20 anterior descending, 22 right and 27 circumflex coronary arteries). In the visual analysis, reversible defects were observed in all patients with occlusion of the anterior descending and the right coronary artery, but only in half of the occlusions of the circumflex coronary artery. The extent of this reversibility was significantly higher in the regions dependent on occluded arteries and was highly variable, though lower when good collateral circulation was present. CONCLUSIONS: Reversible defects were always observed in the occlusions of the left anterior descending and right coronary arteries, but only in half of those of the circumflex artery. The extent of the ischemia was higher in the regions dependent on one occluded coronary artery, mainly when there was an absence of good collateral circulation.
Aged↗
[Role of noninvasive examinations in the management of ischemic heart disease.IV. Nuclear cardiology in chronic ischemic heart disease].
Nuclear cardiology has progressed in the past few years to the point of obtaining a consolidated position in the management of chronic ischemic heart disease. In the first part of our, methodology and interpretation criteria of the fundamental nuclear techniques (myocardial perfusion imaging and radionuclide angiography) are reviewed. In the second part, clinical indications in diagnostic and prognostic evaluations of patients with chronic ischemic heart disease are discussed, while remembering its usefulness in myocardial viability assessment.
Coronary Disease↗
[Stress myocardial gammatomography in the diagnosis of multivessel coronary disease].
OBJECTIVE: The aim of the study was to evaluate the diagnostic yield of 99m-Technetium-methoxy-isobutyl-isonitrile (MIBI) SPET for identification of individual coronary artery disease and in the prediction of multivessel involvement. METHODS: Stress/rest myocardial SPET and coronary arteriography were evaluated in 231 consecutive patients (age 58 +/- 10 years, 26% women) without prior myocardial infarction. 149 patients had coronary narrowing > 50%: 104 with multivessel disease and 45 with one vessel disease. Tomographic stress defect score was obtained by semiquantitative analysis (maximal score 65). Univariate and multivariate analysis was performed to identify discriminant parameters between one vessel and multivessel patients. RESULTS: The sensitivity and specificity for the identification of individual artery disease was 74% and 85% for left anterior descending artery, 79% and 85% for right coronary and 45% and 96% for circumflex artery. In the prediction of multivessel involvement the sensitivity was 65%, specificity 87%, positive predictive value 81% and negative predictive value 76%. In the bivariate analysis, four parameters differed significantly between one vessel and multivessel disease patients: ST downslope > 1 mm (p = 0.01), ST downslope/heart rate corrected (p = 0.005), reversible defects in two or more regions (p = 0.009) and SPET score (p = 0.002). In the multivariate analysis the probability of multivessel disease was 90% when ST depression > 1 mm and SPET score > 20 were associated and the probability was lowered to 16% when these criteria were not present. CONCLUSION: Myocardial SPET with MIBI offers an accurate localization of individual coronary artery disease, mainly in left anterior descending artery and right coronary artery lesions. Combined evaluation of ST depression and extension of myocardial stress defects improved prediction of multivessel involvement.
Coronary Disease↗
[Diagnosis of coronary disease by means of stress gamma-tomography with 99m-technetium-isonitriles].
BACKGROUND: To assess the yield of exercise myocardial stress tomogammagraphy (SPET) with methoxy-isobutyl-isonitrile-technetium-99m (99mTc-MIBI) in the diagnosis of coronary artery disease. METHODS: Seventy-two consecutive patients, without previous myocardial infarction and with coronary angiography, were investigated. All underwent a symptom-limited exercise test with intravenous infection of 15 mCi of 99mTc-MIBI 30-60 seconds before the end of exercise. Detection of tomographic images was performed after one hour. Rest images were detected 24 hours later. Images with exercise perfusion defects which became normal at rest were considered as positive. RESULTS: Sensitivity (84%), specificity (93%), global value (87%), positive predictive value (95%), and negative predictive value (79%) of 99mTc-MIBI were significantly higher than those of conventional exercise electrocardiogram (46%, 69%, 55%, 69% and 46%, respectively). These values were lower when exercise test was insufficient (peak heart rate below 80% in the absence of angina). The sensitivity values were similar for the diagnosis of one (81%), two (76%), and three (93%) vessel disease. The application of Bayes' theorem disclosed that the highest yield of MIBI was achieved with prevalences ranging between 30% and 70%. CONCLUSION: The efficacy of 99mTc-MIBI SPET for the diagnosis of coronary artery disease was satisfactory, particularly when exercise was sufficient and with a prevalence of coronary artery disease ranging between 30% and 70%.
Coronary Disease↗
[ST segment elevation during exercise test and perfusion scintigraphy in patients without infarction].
BACKGROUND: The features of perfusion scintigraphy in patients who show exercise-induced ST-segment elevation in the absence of previous infarction have been assessed in only a few reports. Therefore, we have evaluated our experience in a wide review of exercise 201-thallium scintigraphies. METHODS: 16,620 exercise 201-thallium scintigraphies, carried out between 1986 and 1993, have been retrospectively reviewed. Fourteen patients (0.8/1000) without previous infarction who were evaluated for chest pain showed ST-segment elevation. In all patients coronary arteriography was also available. RESULTS: Five patients were free from significant coronary artery stenoses, 6 had one-vessel disease, 2 had two-vessel disease, and the remaining patient had three-vessel disease. In 8 patients ST-segment elevation (up to 3-24 mm) was inferior, in 5 anterior and in 1 lateral. The radionuclide was injected during ST-segment elevation in 10 cases and before such elevation (which developed in the postexercise phase) in 4. In 3 out of these 4, which had angiographically normal coronary arteries, the scintigraphy was negative. In all cases where thallium-201 was injected during ST elevation, severe perfusion defects were detected corresponding to the localization of ST elevation. In the 4 patients with critical coronary stenoses, thallium-201 redistribution after 3 hours was partial. CONCLUSIONS: In patients without previous infarction and with exercise-induced ST-segment elevation, very severe perfusion defects are detected when the radionuclide has been injected during the crisis. Thallium-201 redistribution after 3 hours was not total in patients with fixed critical stenoses. When radionuclide injection preceded the crisis, the result of the scintigraphy was in agreement with the coronary anatomy.
Adult↗
[Myocardial contractility and viability. A radionuclide tomography study using technetium-99m labeled isonitriles].
BACKGROUND: There are comparatively few studies evaluating the patterns of myocardial viability and its relation with contractility in patients with coronary artery disease. The aim of the present study was to quantify the viable and nonviable myocardium, using 99m-technetium isonitriles SPET, as related with left ventricular regional wall motion abnormalities. METHOD: 61 consecutive patients with coronary artery disease were investigated. The severity and extension of the defects were evaluated using a qualitative and quantitative analysis of the 99mTc-isonitriles SPET and compared with ventricular wall motion in contrast ventriculography. An uptake level of 40% of peak uptake or higher was considered as indicating viable myocardium. RESULTS: Of the 244 evaluated regions (4 per patient), 72 (29%) had normal perfusion, 100 (41%) were ischemic, 25 (10%) had a mild irreversible defect and 47 (19%) had a severe irreversible defect. Wall motion was normal in 176 regions (72%), 29 (12%) were hypokinetic, and 39 (16%) were akinetic of dyskinetic. The amount of viable myocardium in akinetic and dyskinetic regions (64.8%) was significantly different (p < 0.05) from that in hypokinetic (86.1%) and normokinetic (98.8%) regions. Visual assessment of uptake underestimated myocardial viability, as quantitative analysis disclosed that in 61% of akinetic and dyskinetic regions with severe irreversible defects there was more than 50% of viable myocardium. CONCLUSIONS: In 61% of akinetic and dyskinetic regions with a severe irreversible defect in perfusion scintigraphy positive viability criteria were found. Therefore, visual assessment of the myocardial perfusion studies using 99mTc-MIBI SPET underestimates viable myocardium. Tomographic studies with quantification of the uptake and defect extension are required for a proper evaluation of viable myocardium.
Adult↗
[Imaging technics for the detection of myocardial ischemia: pharmacological stress echocardiography or isotope perfusion studies? The isotopic perspective].
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Coronary Disease↗
[The postinfarct prognostic value of right ventricular systolic function].
BACKGROUND: Right ventricular extension of inferior myocardial infarction has been shown to be a predictor of poor prognosis during the acute phase. However, it is not known whether right ventricular dysfunction predicts long term complications. The aim of the present study was to assess whether right ventricular ejection fraction is also a predictor of poor prognosis during the first five follow-up years. METHODS: Ninety-eight consecutive patients (age < or = 65 years) with acute noncomplicated myocardial infarction (49 anterior and 49 inferior) were evaluated before hospital discharge. In all of them the ejection fraction of both ventricles was evaluated with radionuclide ventriculography at rest and during submaximal exercise. All patients were clinically followed up for at least 5 years. The prognostic relevance of right and left ventricular function for the prediction of all complications and severe complications was assessed using univariate and multivariate analysis. RESULTS: After 5 years, 66 patients had 94 complications (angina in 44, heart failure in 21, reinfarction in 10, revascularization procedures in 11, death in 6). In the univariate analysis, resting right ventricular ejection fraction was significantly lower in patients with inferior infarction and severe complications at one year (32 +/- 12% vs 38 +/- 6%, p = 0.03). However, in multivariate analysis only resting left ventricular ejection fraction was predictive of complications at 5 years (odds ratio 5.93, 95% confidence interval = 1.32-26.6). Statistical results did not change when the ejection fraction of both ventricles during submaximal exercise was considered. CONCLUSIONS: Although right ventricular ejection fraction, measured before hospital discharge, is predictive of complications at five years in inferior infarctions, multivariate analysis shows that it does not add prognostic information to the measurement of left ventricular ejection fraction in patients with uncomplicated acute myocardial infarction, either anterior or inferior.
Chi-Square Distribution↗
[Role of noninvasive techniques (electrocardiogram, Holter, tilt-table test, nuclear magnetic resonance, isotopes) in the evaluation of patients with hypertrophic cardiomyopathies].
In most patients with hypertrophic cardiomyopathy the electrocardiogram is abnormal (left ventricular hypertrophy, abnormal Q waves, giant T waves, ST segment elevation). Occasionally, the localization of ventricular hypertrophy may be suggested by the electrocardiogram. Holter monitoring should always be performed in these patients as it permits to assess one of the leading prognostic factors, i.e. nonsustained ventricular tachycardia. Head-up tilt test may point to the mechanism of syncope, and thus be helpful in patients with this symptom. In patients with poor acoustic window, magnetic resonance imaging and perfusion single-photon emission tomography may give useful additional morphological information. Recent studies indicate that patients with perfusion defects have poorer prognosis, but this suggestion should be validated in wider series. Finally, radionuclide ventriculography is the most reproducible technique for the follow up of ventricular systolic and diastolic function and response to therapy.
Cardiomyopathy, Hypertrophic↗
[Perfusion tomographic scintigraphy and coronary angiography as complementary studies for the therapy decision for patients with ischemic cardiopathy].
BACKGROUND: The aim of the present study was to assess the value of tomographic perfusion scintigraphy as a complement to coronary arteriography in the therapeutic management of patients admitted to the hospital for treatment of unstable ischaemic heart disease. METHODS: A review was carried out of the discharge report of 100 consecutive patients (mean age 58 years, 19 females) in which there was a mention of having taken a therapeutic decision on the basis of coronary angiography and tomographic perfusion scintigraphy with 99m-technetium isonitriles under exercise and/or dipyridamole. In 90% of instances the study was performed during drug therapy after the patient had remained stable for at least 3 days. The indication of the studies and the type of therapy was made by the attending physician. Concordance between both studies was said to exist when both pointed to the same type of therapeutic approach, either medical treatment (nonsevere stenosis on coronary arteriography with mild ischaemia on scintigraphy) or revascularization (severe stenosis with moderate or severe ischaemia in tomographic scintigraphy). Discordance was said to be present when ischaemia was mild with severe stenosis on coronary angiography. RESULTS: In 80 patients there was concordance between both studies regarding the subsequent therapeutic approach (medical treatment in 32 and revascularization in 48 [25 coronary angioplasty and 23 bypass surgery]). In the patients with discordance (n:20) medical treatment was decided in 14 patients on the basis of mild ischaemia with significant angiographic stenosis, and in only 6 patients revascularization (angioplasty in 5 and bypass surgery in 1) was indicated, based on the severity of coronary stenosis even if the ischaemia apparent on the scintigraphy was mild. CONCLUSIONS: Therefore, in 80% of patients admitted for unstable coronary artery disease there was a concordance between the results of tomographic scintigraphy and coronary angiography, when both studies were indicated to select the most appropriate therapeutic modality. In the 20% of discordant cases the attending physician decided on a conservative strategy in most cases, as no significant enough perfusion defect was shown on scintigraphy in spite of severe coronary artery stenosis.
Coronary Angiography↗
[Technetium-99m isonitrile versus thallium 201 in coronary disease].
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Contrast Media↗
[A report on new imaging technics in cardiology. The Expert Panel of the General Deputy Administrative Office of Health Technology Services and Assessment].
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Cardiology↗
[The usefulness of transesophageal echocardiography in assessing mechanical mitral prostheses. A comparison with transthoracic echocardiography].
One hundred and sixty mechanical mitral prostheses were studied by transoesophageal echocardiography to ascertain the role of this technique in their functional assessment. All patients underwent transoesophageal echocardiogram, and, in 83, transthoracic Doppler-echocardiogram had already been performed immediately prior to transoesophageal echocardiogram. Prostheses presenting structural anomaly on bidimensional image and/or areas of regurgitation with predominantly turbulent flow on colour Doppler were considered to be dysfunctional. Of the 160 prostheses, 115 were considered normofunctional, and regurgitation was detected in 85 (94%) by transoesophageal echocardiogram and 10 (9%) by transthoracic echocardiogram; haemodynamic and/or surgical confirmation was obtained in 6 of these prostheses and all proved to be functioning normally. Of the 45 remaining prostheses considered to be dysfunctional, haemodynamic and/or surgical confirmation was obtained in 21 (the non-confirmed 24 were excluded from the study). Seventeen of the dysfunctional prostheses presented with areas of regurgitation of 3.9-24 cm2 (mean: 9.21 + 5.36); in one case, the degree of regurgitation with respect haemodynamic study was over-assessed; transthoracic echocardiogram detected only periprosthetic leaks in 38% of cases, with areas of regurgitation of 1.8-6.3 cm2 (mean: 1.87 + 2.02). The other 4 dysfunctional prostheses presented dysfunction due to thrombosis; all 4 were diagnosed by both transthoracic and transoesophageal echocardiogram. Transoesophageal echocardiogram detected 12 structural anomalies (1 vegetations, 4 thromboses and 7 dehiscencies), whereas transthoracic echocardiogram only detected these anomalies in five of the cases (1 vegetations and 4 thromboses). Transoesophageal echocardiography surpasses transthoracic echocardiography in the assessment of mechanical mitral prostheses and dysfunction diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)
Echocardiography↗
[A cost-effectiveness analysis of prognostic studies in acute uncomplicated myocardial infarct].
INTRODUCTION AND OBJECTIVES: The prognostic assessment of the acute myocardial infarction may be obtained through clinical criteria, particularly in patients who are symptomatic during admission, or with several studies in patients without complications. The "effectiveness" of such investigations has been long studied, but not so their "efficiency", which analyses the relationships between costs and outcomes. The goal of the present study is to report the results of a cost-effectiveness analysis of various combinations of diagnostic tests. METHODS: One hundred and fifteen patients (age < 65) with uncomplicated first acute myocardial infarction were evaluated. In all patients exercise test, two-dimensional echocardiogram thallium-201 scintigraphy, radionuclide ventriculography, Holter monitoring and cardiac catheterization were performed. The effectiveness was calculated as the "global value" (rate of correctly diagnosed patients: complications prediction during the first year follow-up) of every of such tests combinations. We have used the direct differential costs estimated following the "Colegio Oficial de Médicos de Barcelona" standards. The index used in the cost-effectiveness analysis was the medium cost person/global value. The lowest index corresponded to the most efficient test combination. RESULTS: The highest effectiveness was found for the exercise test plus bidimensional echocardiography combination (global value = 0.64). At the same time it was the less expensive combination (medium cost = 14.444 ptas); therefore, its index was the lowest (21.724 ptas/patient). CONCLUSIONS: In patients with a first uncomplicated myocardial infarction, the performance of exercise test and echocardiogram is the less costly and most effective combination of studies for one year prognosis. In these patients, routine cardiac catheterization does not improve the results.
Chi-Square Distribution↗