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Biomedical subjects

J Candlish

Publications and source records attributed to J Candlish.

7 recordsLinked to original sources

The legality of slimming advertisements in Singapore.

Governments in newly affluent countries like Singapore perceive a growing obesity problem, which in turn attracts the attention of numerous suppliers of slimming aids of dubious value. Advertisements relating to these appear in many cases to breach the Sale of Food Act and the Medicines Act. Under these provisions, oral and transdermal slimming aids which are not prescription drugs or on the General Sales List must have a permit if they are to be advertised, which is granted if the authorities are satisfied as to the existence of evidence for efficacy. If perceived to be harmful, however, a product can be banned and if the associated advertisement is misleading it will attract a financial penalty. Slimming aids formally excluded (like herbal preparations) can be brought under the Act by executive order and banned from sale. That this formidable array of controls is rarely applied is due to the voluntary regulatory machinery of an advertising standards authority, a non-governmental body with a parallel in many other countries. However it has limited resources. It is suggested that either the executive or the advertising authority or both could adopt more rigorous criteria for the application of the law in the interests of the public.

Advertising↗

Delta bilirubin changes following phototherapy for neonatal jaundice.

The effect of phototherapy for neonatal jaundice on the serum concentrations of total, unconjugated, conjugated and delta bilirubins were studied in 91 infants. Only unconjugated bilirubin concentration declined during phototherapy, from 254.7 +/- 7.0 mumol/l (mean +/- SD) at start to 161.4 +/- 37.4 mumol/l at cessation after 50.2 +/- 22.1 hours of exposure. Conjugated and delta bilirubin concentrations, initially already very low, were not significantly affected. Phototherapy was only efficacious for unconjugated bilirubin and did not have any effect on delta or conjugated bilirubin.

Bilirubin↗

Vitamin E and lipogenesis in the mammalian liver.

Mice on tocopherol-supplemented and cod-liver-oil-enriched diets were given intraperitoneal injections of tritiated water. The fatty acids and cholesterol from their livers were then extracted and counted. Tocopherol supplementation depressed fatty acid but not cholesterol synthesis. Cod-liver oil (a vitamin E antagonist) elevated fatty acid but not cholesterol synthesis. In both cases, these effects were cancelled or reversed after about 20 days' ingestion of the diet.

Animals↗

Studies of the chemical composition of a healing skin wound in rats, and of the concentrations of some constituents of tissues distant from the healing wound.

1. A skin lesion was made in rats by dorsal incision and the insertion of a polythene tube. 2. Over a period of 25 days after wounding, assays were performed for ascorbic acid, DNA, hydroxyproline, methionine, tryptophan, tyrosine and free amino acids in the lesion tissue. 3. The neutral-salt-soluble proteins of the lesion tissue were fractionated on DEAE-Sephadex, with the separation of fibrinogen and gamma-globulin from a serum protein fraction. 4. Over a period of 20 days after wounding, in wounded rats and in controls, assays were conducted for: ascorbic acid in lens and liver, hydroxyproline, soluble protein, methionine and water in muscle and tendon, and free amino acids in muscle. 5. Relative to controls there was a decrease in lens and liver ascorbic acid, a rise in tendon hydroxyproline, a rise in muscle free amino acids, a fall in muscle protein and a rise in tendon and muscle water.

Journal Article↗