[Medical audit: influenza. Group of Physicians for Quality Assurance, Fribourg].
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Biomedical subjects
Publications and source records attributed to J Carrel.
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Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the Peutz-Jeghers syndrome are described in a 56 year old female and her 29 year old son. Both mother and son died from duodenal and gastric carcinomas respectively, which developed in hamartomatous polyps with extensive metastases. Both cases also showed dysplastic areas within hamartomatous polyps. These features indicate that hamartomatous polyps may, in some cases, be the precursors of digestive tract carcinomas.
In a search for group B streptococci, vagina and urethra of 196 pregnant women entering the delivery room were cultured using a selective medium. Sixteen (8.2%) were positive. Fifteen (15%) of 101 nonpregnant women cultured similarly during a clinical consultation were positive. Esogastric aspiration fluid of 199 neonates from the former group of women was also cultured: 8 (4.0%) were positive. Thus, maternal genital colonization was accompanied by neonatal contamination in 7 of 16 cases (43%). Typing of the streptococci revealed identity between all maternal and neonatal isolates tested. These values are comparable with those obtained in other countries. Their epidemiological implications and the prophylaxis and therapy of the neonatal disease are discussed.
A case of severe enterocolitis which occurred on initiation of chrysotherapy for rheumatoid arthritis is reported. The patient, a male aged 50 years, suffered from dramatic diarrhea for several weeks. Biopsy specimens from the stomach, ileum and colon revealed signs of inflammation. Later, general toxicodermia, mouth ulcers, blood eosinophilia and asymptomatic proteinuria were observed. After several months all the side effects disappeared. The toxicodermia was the most persistent.
Larvae of the sawfly Neodiprion sertifer (Hymenoptera: Diprionidae), when disturbed, discharge an oily oral effluent essentially identical chemically to the terpenoid resin of its host plant (Pinus sylvestris). The resin is sequestered by the larva upon feeding, and stored in two compressible diverticular pouches of the foregut. The fluid is effectively deterrent to predators. The defensive use by an insect of a plant resin provides an instance of secondary utilization by a herbivore of the protective chemical weaponry of its host.