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Biomedical subjects

J Cauchoix

Publications and source records attributed to J Cauchoix.

At least 19 recordsLinked to original sources

Nucleolysis of the rabbit intervertebral disc using chondroitinase ABC.

The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.

Animals

[Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit].

Nucleolysis using chondroitinase ABC was studied using the rabbit's intervertebral lumbar disc. The purpose was to find a possible alternative to chymopapain which is commonly used in the management of sciatica due to disc herniation. The injection of 1 U of the enzyme into the nucleus pulposus gave significant histological and biochemical changes in all twelve discs studied.

Animals

[Lumbar arthrodesis: results after more than 10 years].

Two hundred and seventy four patients had a lumbar spine fusion between 1949/1971. Seventy-five of them were available for review more than 10 years after the procedure. There were twenty spondylolisthesis, forty-eight degenerative discopathies, six cases of Pott's disease and one benign tumour. All the patients had been treated conservatively before the surgical procedure for an average of 7 years and were still complaining of chronic low back pain. All the cases reviewed had fused. The functional results were not related to the surgical technique, which varied during this period: eight posterior mid-line grafts, seventeen interbody fusions and fifty combined anterior and posterior approaches sometimes used because of a primary failure of fusion and no postero-lateral fusions. The average follow-up was 13 years with a range from 10 to 26 years. The clinical results were satisfactory in 74 p. 100 of the cases. There were thirteen failures. Seven of these patients had been operated on before the era of systematic preoperative discography and psychological evaluation and the failure was primary. Other failures were observed at about the tenth post-operative year. The results were better in spondylolisthesis with isthmic lesions, rather than in degenerative spondylolisthesis. They were better in pure low back pain than when the pain associated with sciatica. They were better when fusion was limited to one or two levels. Radiographs ten years after the procedure frequently showed evidence of degenerative lesions of the disc above the level of the fusion and, at the same time, some slipping of the upper vertebra. Fortunately, there was no correlation between the radiological appearances and the clinical results.

Adolescent

[Postoperative sciatica from epidural fibrosis and lumbar arachnoiditis. Results of 38 repeat operations].

Lumbar epiduro-arachnoiditis is a well-known complication of surgery of the intervertebral disc. The epidural fibrous scar is the normal outcome of inflammatory activity secondary to the mechanical tissue disturbance resulting from surgery. In certain individuals, perhaps genetically predisposed as excessive quantity of fibrous tissue is deposited in the epi and/or nitradural space. This abnormal situation, comparable to cheloid cutaneous scars, is perhaps at the origin of the clinical symptoms. The authors report the clinical and radiological signs observed in 38 patients having had at least one operation for discal hernia, and who underwent further operations in the aim of freeing the roots and the dural sack from fibrous compression. Results of excision of the epidural "cheloid" were good in 13 cases, and average in 8 others. There was a complete failure in 17 other patients. Three explanations were offered to explain the frequency of the failures: 1) formation of a new cheloid, 2) difficulty of neurolysis of the arachnoiditis, 3) possibility of intrinsic lesions of the nerve associated with the epiduro-arachnoiditis.

Adult

Repeat surgery after disc excision.

Sixty patients requiring repeat surgery after lumbar disc excision are reviewed. Thirty-one had had their initial surgery performed by the authors and represent a 5.9% frequency of repeat surgery after initial laminectomy for sciatica. Of the 60 patients, 49 suffered recurrent radicular pain, 20 suffered from back pain, and 8 had other problems (infection, extradural cysts, etc.). In patients with recurrent sciatica, perineural fibrosis and recurrent herniation were the most common problems; those patients with the latter pathologic condition responded most favorably to repeat surgery. Of 520 patients who had undergone disc excision, only 9 required secondary fusion.

Adult

One stage femoral lengthening.

Femoral lengthening can be obtained by a technique using a Z osteotomy and a distraction device separate from the operative field. The expected gain in length is 3-3.5 cm in children, 4-4.5 cm in adults. Sustained flexion of the knee during the procedure prevents vascular and nervous complications. One peroneal nerve and 2 femoral nerve palsies were nevertheless observed in 180 cases of the whole series. These were caused by a failure to comply with technical details. Bony union occurs promptly in young children. Pseudarthrosis occurred 11 times in patients more than 16-years-old, and once in an 8-year-old child. Avascular necrosis of the bone fragments after total separation of the soft tissue from the femoral shaft explains the frequency of non-union after the age of skeletal maturity. Faster and sound union in adolescents and adults is obtainable by the use of decortication to exposure the femur and strong internal fixation. The best indication for this method is a moderate discrepancy allowing a safe and complete equalization of limb length.

Adolescent

[Degenerative spondylolisthesis. Clinical manifestations and treatment apropos of 26 operated cases].

The authors report 26 cases of surgically treated degenerative spondylolisthesis. Twelve patients complained of permanent uni or bilateral sciatica. All the others had a syndrome of intermittent claudication with pain and paresthaesia. The authors stress once again the highly evocative nature of this syndrome which reflects involvement of the nerve roots in the stenosed lumbar canal. Treatment consisted of lamino-arthrectomy which resulted in the disappearance of symptoms in most of cases. In four cases, vertebral slipping worsened during the post-operative cowise with, in three cases a recurrence of symptoms necessitating a complementary arthrodesis. This risk of increased slipping is a result of the instability created by the arthrectomy, especially when it is bilateral, and has led the authors to widen their indications for routine complementary postero-lateral arthrodesis.

Aged

[Dorsal tenosynovectomy of the wrist in rheumatoid arthritis. Results obtained in 30 cases].

With reference to a series of thirty synovectomies of the wrist in patients with rheumatoid arthritis, the authors report the results observed after an average interval of three years and six months. There was a remarkable reduction in pain in three-quarters of the cases. On the other hand, loss of mobility was noted in 15 patients. Resection of the cubital head was carried out in half of the cases. This was followed in two cases by internal translocation of the carpus, and in three cases by internal translocation combined with cubital inclination of the hand. The results of the tenddon repairs carried out in six patients have been completely satisfactory. A study of the present cases and of data from the literature confirms the local prophylactic value of tenosynovectomy which may also prevent tendon ruptures. The best result are seen in the less evolutive forms in which the risk of relapse is least, and in cases in which surgery is carried out on stable wrists with cartilage showing little alteration. In the presence of inferior radiocubital arthritis the resection must be systematic as it makes it possible to carry out a complete synovectomy of this joint. The authors compare the value of surgical synovectomy of the wrist with that of radioactive synoviorthesis.

Adult