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Biomedical subjects

J Causse

Publications and source records attributed to J Causse.

At least 19 recordsLinked to original sources
PubMed1982

[Antibacterial therapy in surgery of the inner and middle ear. A study of co-trimoxazole penetration into the perilymph (author's transl)].

Studies of the type presented here have rarely been undertaken and should be useful in surgery and pathology of the inner and middle ear. Samples of perilymph were collected during stapedectomy in patients with otosclerosis. In view of the very small volume of perilymph obtainable from each patient's vestibule (2 to 4 microliter), the only assay method that could be used to measure drug levels was thin layer chromatography on silica gel. Despite pooling of the perilymphs of 5 patients, trimethoprim (TMP) levels could not be measured but the authors were able to demonstrate that sulfamethoxazole (SMZ) does penetrate into the perilymph. Since the TMP-SMZ combination (co-trimoxazole) is active against the pathogens usually encountered in middle ear fluids, it is concluded that the drug could be of benefit in the treatment of middle and inner ear infections or after surgical operations on this area.

Adult↗
PubMed1982

Bone resorption in otospongiosis.

"Considerable interest has been raised in recent years concerning the basic mechanisms involved in bone destruction and rebuilding in the otospongiotic focus. Under general bone resorption the osteoclasts play a decisive role, but in otospongiotic tissue electron-microscopic and cytochemical studies have shown that osteoclasts alone are not responsible for the bone resorption. Mononuclear histiocytes found in the marrow spaces and in the surrounding bone of an otospongiotic focus together with osteocytes take active part in the resorption. Cytochemical studies of acid phosphatase activity have shown that hydrolases in the lysosomes are expelled into the surrounding tissue, resulting in its resorption.

Acid Phosphatase↗
PubMed1981

Surgeon's workshop: Eighteen-year report on stapedectomy. IV. Long-term functional results.

This is the last of a series of 4 articles detailing the history of 20893 stapedectomies over an 18-year period. In this fourth part, the authors study long-term functional results in relation to the type of stapedectomy, the importance of the cochlear involvement and the general pathology, mainly vascular. The come to the conclusion that good long-term functional results imply the necessity of combining a carefully performed stapedectomy using a living tissue graft, a strict audiometric surveillance and an adequate postoperative therapy, including (if necessary) an extensive fluoride therapy.

Cardiovascular Diseases↗
PubMed1980

Eighteen-year report on stapedectomy. II. Postoperative therapy.

This second section deals with the basis of postoperative therapy following stapedectomy. They develop first the immediate postoperative care, then maintenance therapy, mainly NaF therapy to slow down or arrest cochlear enymatic deterioration, if needed.

Adult↗
PubMed1980

Eighteen-year report on stapedectomy. I. Problems of stapedial fixation.

This first section deals with various techniques performed by the authors who conclude in favour of a living tissue graft sealing the oval window, particularly Teflon-piston against veingraft, i.e the "Teflon-interposition' technique. Intra-operative problems of associated diseases and of the technical difficulties encountered during stapedectomy, are related and their treatment explained. Revision operations and immediate postoperative therapy end this first part.

Anesthesia↗
PubMed1979

A new nystagmographic test for the elicitation of sub-clinical vertebro-basilar insufficiency and poor cochleo-vestibular vascularization.

The nystagmus due to vertebro-basilar artery insufficiency is that nystagmus which is induced by torsion and extension of the neck, continued for more than 3 minutes, after nystagmus of other types has been excluded. It is of vascular origin, in contra-distinction to nystagmus of cervical origin, which is proprioceptive. It permits the detection of sub-clinical vertebro-basilar insufficiency, and it should be elicited before any operation which requires prolonged cervical rotation. It is a very simple method which can be performed at the end of the classical torsion swing test, and we have found the results very informative.

Cochlea↗
PubMed1978

[Vertebral-basilar artery insufficiency nystagmus (author's transl)].

The vertebral-basilar artery insufficiency nystagmus is the nystagmus induced by torsion and extension of the neck, continued for more than three minutes, after nystagmus of other origin has been excluded. It stands particularly in opposition with the nystagmus of cervical origin, which is proprioceptive. On the contrary, vertebral-basilar artery insufficiency nystagmus is of vascular origin. It enables the detection of an infra-clinical vertebral-basilar insufficiency. It deserves to be elicited before subjecting patients to any operation requiring prolonged cervical rotation.

Basilar Artery↗
PubMed1977

Cochlear otospongiosis etiology, diagnosis and therapeutic implications.

First, the authors discuss the most valuable way to correlate specific morphological changes encountered in cochlear otospongiosis with sensorineural hearing loss. They think that biochemical factors may be responsible for this association of cochlear otospongiosis and histopathologic changes, and they explain their enzymatic concept resulting from experimental findings and cyto-clinical relationship. Second, the authors analyze clinical, audiometric and X-Rays investigations enabling the diagnosis of cochlear otospongiosis, in its pure pereceptive form as well as in the perceptive component added to the conductive loss in far-advanced mixed audiometric types in surgical otospongiosis. They present two typical cases of cochlear otospongiosis: one combines clinical history, audiometric test and post mortem investigations;-the other shows the passage from a pure cochlear otospongiosis to a secondary stapedial fixation, ten years later, thus confirming by audiometric data and by stapedectomy the otospongiotic etiology of this previous pure sensorineural loss. Finally, they insist upon the great interest of establishing an early diagnosis in cochlear otospongiosis on account of its therapeutic implication, particularly from the enzymatic point of view.

Adult↗