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Biomedical subjects

J Cawley

Publications and source records attributed to J Cawley.

12 recordsLinked to original sources

An instrumental variables approach to measuring the effect of body weight on employment disability.

OBJECTIVE: To measure the effect of body weight on employment disability. DATA SOURCES: Female respondents to the National Longitudinal Survey of Youth (NLSY), a nationally representative sample of American youth, surveyed from 1979 to 1998, merged with data from the child sample of the NLSY. STUDY DESIGN: A series of probit models and probit models with instrumental variables is estimated with the goal of measuring the effect of body weight on employment disability. The two outcomes of interest are whether a woman reports that her health limits the amount of work that she can do for pay, and whether she reports that her health limits the kind of work that she can do for pay. The models control for factors that affect the probability of health limitations on employment, such as education, cognitive ability, income of other family members, and characteristics of children in the household. Self-reports of height and weight are corrected for reporting error. PRINCIPAL FINDINGS: All else being equal, heavier women are more likely to report employment disability. However, this overall correlation may be due to any or all of the following factors: weight causing disability, disability causing weight gain, or unobserved factors causing both. Instrumental variables estimates provide no evidence that body weight affects the probability of either type of employment disability. CONCLUSIONS: This study finds no evidence that body weight causes employment disability. Instead, the observed correlation between heaviness and disability may be due to disability causing weight gain or unobservable factors causing both disability and weight gain.

Adult↗

Developing a maternity home care program.

Maternity patients are being discharged from hospitals earlier than ever. This maternity care program provides new mothers with comprehensive home care that ensures healthier mothers and babies.

Adult↗

The mechanism of action of interferon-alpha (IFN-alpha) in hairy-cell leukaemia; Hu-IFN-alpha 2 receptor expression by hairy cells and other normal and leukaemic cell types.

To investigate the possible direct effects of interferon-alpha (IFN-alpha) in hairy-cell leukaemia, IFN-alpha receptor expression by hairy cells (HCs) (11 cases) was measured by a radiolabelling technique and compared with that of MOLT-4, chronic lymphocytic leukaemia (CLL; 14 cases) and various other leukaemic and normal cell types. Purified peripheral blood (PB) and splenic HCs showed higher levels of receptor expression (approx. 1000 +/- 200 binding sites/cell; 11 cases tested) than other normal and leukaemic cells types. Purified normal PB and tonsil B cells showed low levels of receptors (approx. 120 +/- 100 binding sites/cell), while a range of B-cell leukaemias displayed intermediate levels of expression (approx. 100-500 sites/cell). In the 15 cases of CLL tested, 530 +/- 330 binding sites/cell were demonstrated, the high standard deviation reflecting the fact that approximately one third of cases had receptor levels comparable with those in HCL. Normal and HCL T cells, red cells and platelets had no demonstrable IFN receptors. It is suggested that these findings may be relevant to the efficacy of IFN in hairy-cell leukaemia.

B-Lymphocytes↗

Cytochemistry, cytogenetics and ultrastructure of hamster tumour cells carrying mouse sarcoma viral genome (HT-1 cells).

The pleomorphic cytology of the HT-1 cell line is described. Cytochemical studies indicated the presence of glycogen and lysosomes in these cells. Cytogenetic studies demonstrated the presence of a large telocentric chromosome (M1) and two minute chromosomes (M2) not found in normal hamster cells. A cloned line was isolated which did not contain these marker chromosomes. All cells were hyperdiploid with chromosome number around triploidy, although none was a true triploid. Ultrastructural studies revealed the presence of "nuclear bodies", "dense bodies" and "interchromatinic granules" which have been previously described in viral induced malignancies. A few of the cells contained in their cytoplasm structures of approximately 700 [unk] in diameter which bore some resemblance to immature virus particles. Both light and electron microscopy demonstrated some nuclei lacking chromatin aggregates. This is interpreted to mean that the total genetic material of these nuclei was dispersed as free DNA not linked with histone to form chromatin aggregates.

Animals↗