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Biomedical subjects

J Cerilli

Publications and source records attributed to J Cerilli.

At least 55 records · Page 3Linked to original sources
PubMed1977

A reappraisal of the role of splenectomy in children receiving renal allografts.

Four renal allograft recipients between 8 and 14 years of age died of acute fulminating infections less than 72 hours after the onset of symptoms. These patients all had undergone splenectomy at the time of related donor renal transplantation. Because the therapeutic value of splenectomy in renal transplantation has not been established, the role of adjunctive splenectomy is evaluated, and the relationship between splenectomy and overwhelming infection is discussed. As a result of these acute deaths in 4 of 62 children undergoing renal transplantation at this institution (6.4%), splenectomy in conjunction with renal transplantation in children has been discontinued.

Acute Disease↗
PubMed1976

Renal transplantation in patients with urinary tract abnormalities.

Patients with chronic renal failure and total diversion of the lower urinary tract have been considered poor transplant candidates, and post-transplant urinary diversion, i.e., Bricker loop, has been thought to be necessary. Our experience with nine patients clearly indicates that these patients are actually excellent transplant candidates and that post-transplant urinary diversion rarely is necessary. Ureteroneocystostomy of the allografted ureter was performed in seven patients with pretransplant total urinary diversion and all have completely normal bladder and renal function 10 to 66 months after transplantation; the two patients with Bricker loop procedures performed at transplantation died 7 months after transplantation of rejection and pancreatitis. The excellent results achieved with ureteroneocystostomy are attributed to (1) errors in diagnosis resulting in inappropriate bladder or ureteric surgery early in the course of the patient's disease; (2) confusion of immunologic of functional disorders with anatomic problems; (3) growth and development of the bladder, and (4) complete control of chronic bladder infection by pretransplant nephrectomy, ureterectomy, and antibiotics.

Adolescent↗
PubMed1976

The detection and evaluation of migration stimulatory factor in renal allograft recipients.

Seventy-one recipients of related donor renal allografts were tested for cellular immunity with the direct migration inhibition factor assay. Patients were divided into three groups on the basis of their responses in the assay. It was shown that all patients whose lymphocytes stimulated macrophage migration in vitro experienced more benign clinical courses than did those patients whose lymphocytes inhibited macrophage migration in vitro. The significance of a correlation between in vitro macrophage stimulation and clinical course is discussed.

Cell Migration Inhibition↗
PubMed1975

An immunological study of renal allograft rejection using the direct macrophage inhibition test.

The direct macrophage inhibition test was used to evaluate the relationship between cellular immune response and graft rejection in related renal allograft recipients. Forty recipients were evaluated before and at regular intervals after transplantation while on maintenance immunosuppressive therapy. Allograft recipients were classified into four categories: 1) Non-HL-A-identical with a rejection episode (14 patients); 2) non-HL-A-identical without a rejection episode (13 patients); 3) 3) HL-A-identical with a rejection episode (3 patients); 4) HL-A-identical without a rejection episode (10 patients). Ten HL-A-identical sibling pairs in good health were utilized as controls. Cellular immunity against donor antigen (macrophage inhibition greater than 20%) uniformly occurred in 16 of the 17 patients who experienced episodes of rejection in both the HL-A-identical and nonidentical graft recipient groups. Transplant recipients who did no experience any rejection episodes up to 2 years post-transplant, and members of the HL-A-identical control group had negative inhibition tests. In 5 cases changes in cellular immune response preceded rejection by several days. The two recipients with positive macrophage inhibition to their prospective donors before transplantation experienced irreversible accelerated rejection. Thus, the direct macrophage inhibition test can be used to screen prospective related donors and to monitor cellular immunity in recipients after transplantation. Preexistent cellular immunity to the donor detected before transplantation correlates with a very high incidence of rejection episodes. Graft recipients who experienced no rejection episodes failed to develop cellular immunity to their donors.

Animals↗