PubMed Health⌕ Search

Biomedical subjects

J Cerman

Publications and source records attributed to J Cerman.

16 recordsLinked to original sources
PubMed1989

Peptide hormone expression and precursor processing.

Insight in the mechanisms of peptide hormone expression has grown explosively by elucidation of gene, mRNA and preprohormone structures for most hormone systems during the 1980s. The preprohormones vary considerably in size and organization from poly- to mono-protein structures. According to the structural organization and sequence homology the hormones are grouped in families. The prohormones are processed to bioactive peptides by multiple enzymatic modifications during the intracellular transport from the rough endoplasmatic reticulum to the mature secretory granules. The modifications comprise different proteolytic cleavages and amino acid derivatizations. The same prohormone may be expressed in several different cell-types that process the precursor in entirely different ways. Awareness of such cell-specific processing patterns is important for the understanding of ectopic synthesis in neuroendocrine tumours.

Animals↗
PubMed1989

[Helminthozoonoses in Slovakia 1981-1987].

The incidence of helminthozoonoses in the Slovak Socialist Republic over the years 1981--1987 was assessed on the basis of reports submitted by health and veterinary organizations. The incidence of taeniases exhibited a decreasing trend over the period studied. The occurrence rate of cysticercosis in slaughter cattle was irregularly increasing from 0.65% to 0.90%. Echinococcosis in humans was established only sporadically (4 cases). In animals its extensity was decreasing and dropped to 0.22% in slaughter pigs and to 0.70% in sheep and goats. Trichinosis showed an endemic occurrence (13 cases). Larval toxocariasis increased from 6 to 129 seropositive cases. Hymenolepiasis was diagnosed only in the East Slovakian Region (0.06 to 1.46 cases per 100,000 inhabitants). (Fig. 5, Ref. 3.)

Animals↗
PubMed1977

Serotonin in contused spinal cord.

An intensive experimental spinal cord impact trauma in rabbits led, after 90 minutes, to a significant increase of serotonin content in the segments of spinal cord at the injury epicentres. Adjacent segments showed normal values. It is suggested that the existing contradictory published data concerning the serotonin concentration in a traumatized spinal cord are accounted for by differences between animal species, the method of analysis used, and the technique employed in causing the injury. Potential involvement of serotonin in the autodestructive process is discussed.

Animals↗
PubMed1977

Dynamics of circulating antibodies against Trichinella spiralis after application of anthelmintics.

Formation and dynamics of circulating antibodies were studied in mice experimentally inefected with T. spiralis and treated with mebendazole. Latex-fixation tube was used in the experiment. In the control group of untreated mice the antibodies were detected on the 21st day after infection. The antibody level reached the maximum on day 76 and low titres were found still on day 207 after infection. In mice treated with mebendazole in the intestinal phase of trichinellosis, the antibodies were detected 10 or 7 days earlier than in the control group. At this time the antibody level reached the maximum and then it decreased gradually until no antibodies were detected on days 66-76. This phenomenon correlated with postmortem examination and suggested that the formation and dynamics of circulating antibodies against T. spiralis are directly dependent on the effectiveness of the treatment.

Animals↗