Biomedical subjects

J Cerovská

Publications and source records attributed to J Cerovská.

At least 19 recordsLinked to original sources

PubMed2006

[The volumes of the thyroid gland in adults aged 18-65 years in the Czech Republic--determination of the norms].

OBJECTIVE: In the areas with moderate iodine deficit the sonographic examination of thyroid gland is a precious method of precise determination of its volume. The objective of the work was the sonographic examination of males and females aged 18-65 years and to determine the norms of the volumes of thyroid gland. METHODS AND RESULTS: In total, by random sampling, there were sonographically examined 3 416 adults in 11 areas of the Czech Republic; there was chosen a set of 971 females and 681 males whose iodinuria level in first morning urine sample was equal or higher than 100 microg/l. This set was divided according to sex and into the age categories in 5-year interval. The measurement of 3 dimensions of the thyroid gland was determined by Medison-Kretz SA 600 sonographic device with the use of 7.5 MHz linear probe for the depth and width measurement and 3.5 MHz probe was used for the lengths measurement. The volume was determined for each lobe individually using Brunn's formula: V (ml) = 0.479 x length x depth x width. Our results imply the age-related increase of the volume of thyroid gland at both sexes (F-ratio = 1.99, p < 0.0001). At men and women the volume of thyroid gland fluently increases to the 30th year equally, from 30 years to 55 years it increases more rapidly in men while in women there is observed a moderate plateau. Further increase of the volume of thyroid gland is equally fluent from the age of 55 years. CONCLUSION: We managed to determine first own norms of the volumes of thyroid gland for men and women aged 18-65 years in the Czech Republic in five-year age categories. In terms of practical use we recommend 90th percentile as a limit for the evaluation of upper limit of thyroid gland and the 10th percentile for the evaluation of lower limit of the volume of thyroid gland.

Adolescent↗

PubMed2006

[Changes in iodine supply in adult Czech population after iodine deficit eradication and causes. Random study of adults in two regions in the Czech republic with in between period of 5 years].

INTRODUCTION: By iodine, similar to many other elements that are important for human body, the daily intake has some limitations. Neither deficiency, nor surplus are required. In the second half of the nineties in the 20th century, iodine deficiency in Czech republic could have been eradicated to a great extent. However, changes in iodine supply in population still have to be monitored, looking for the causes in nutrition. AIM: To monitor the changes in ioduria in adult population and search for causes of these changes in dietary habits. METHODS: In 1999, 2000, 2004 and 2005, urinary iodine was determined in randomly selected population of 1139 adults aged 18 to 65, domiciled in the regions Jablonec nad Nisou or Príbram. The measurement of iodine was based on alcaline ashing of urine specimens preceding Sandell-Koldhoff reaction. The information about possible nutrition sources of iodine (seafood, milk, salt, eggs, mineral water) was found out through questionnaires and controlled interviews. RESULTS: During the respective 5 years, significant increase of the mean level of urinary iodine from 117 +/- 3.09 microg/l to 193 +/- 8.17 microg/l occured. In both regions, significant increased frequency of supernormal values of urinary iodine (over 300 microg/l) occured: from 0% to 13-18%. However, the changes in the region Jablonec nad Nisou were more positive than in the other one: decrease of below-normal urinary iodine concentration (50 to 99 microg/l) from 43% to 22% in the region Jablonec nad Nisou was found, while the number of below-normal urinary iodine concentration in the other region increased from 24% to 33% and the number of adults with optimum iodine concentration has also decreased (from 75% to 53%). Nutrition changes of possible influence on the urinary iodine concentration (seafood, milk, eggs, salt, mineral water with iodine) were observed and significant increase in consumption of eggs, mineral water with iodine and milk was found out. The consumption of mineral water with iodine has increased from 5% to 10% in Jablonec nad Nisou and from 15% to 26% in Príbram. Multi-factor analysis of four major nutrition sources of iodine (consumption of milk, seafood, eggs and salt) has proven the biggest influence of regular egg and milk consumption on urinary iodine concentration in adults.

Adolescent↗

PubMed2006

[Selenium deficiency of west Bohemia population].

To estimate status and intake of selenium in inhabitants of the most Western region of the Czech Republic (Cheb region) 241 serum, 404 urine and 30 hair samples from randomly selected persons in the age between 6 and 65 years is performed. Serum and hair samples were analysed by means of instrumental neutron activation analysis (INAA), while Se in urines was detected by means of fluorimetry. Urine iodine was determined in the same group by Sandell-Kolthoff method for the possibility to detect concomitant Se and I deficiency and/or correlations between these two essential trace elements necessary for metabolism of thyroid hormones. Average values of Se indexes are low (55.4 +/- 13.8 microg Se/L serum; 15.4 +/- 5.7 microg Se/L urine; 13.6 +/- 6.0 microg Se/g creatinine; 0.268 +/- 0.051 microg Se/g hair) and prove Se deficiency in the searched population. Statistical evaluation of Se in subgroups of boys, girls, men and women proved significant differences as far as age is concerned, gender differences were found only between boys and girls. Some significant and highly significant differences were found also in subgroups according age and gender (males and females in the age of 6, 10, 13, 18-35, 36-49 and 50-65 years). On the other hand, urine iodine average value (126 +/- 65 microg/L) is on the lower optimum level. By the use of correlation analysis, slight but significant correlations were found between Se and I in urine and some of thyroid hormone parameters and their influence on the organism.

Adolescent↗

PubMed2006

[Iodine and thyroid hormones].

In the years 1995-2002, a survey was conducted involving 5 263 individuals (2 276 males, 2 987 females) between the ages of 6-98. They were selected randomly from the central registery in 7 counties in the Czech Republic. The level of urinary iodine in these individuals was established using the Sandell-Kolthoff rection which was preceded by the alkaline ashing of the samples as follows: (n = 5 263), thyroglobulin (TG, n = 3 902), thyrotropin(TSH, n = 5 162) freee thyroxin (fT4, n = 5 160) and free triiodothyronine (fT3, n = 4 931), where the thyroid hormones, TSH, and TG were determined in serum using immunoassays. The individuals were divided into groups according to their iodine deficiency, i.e. to the group with urinary iodine concentration < 50, 50-100, 100-200, and > 200 microg I/l of urine. In these groups the mean and median of TG, TSH, fT4, and fT3 were calculated. The means and medians of TG and fT4 increased with the decrease of urinary iodine, and conversely TSH decreased with the decrease of urinary iodine. The values of fT3 were relatively unaffected by the changes in the concentrations of urinary iodine. All the hormonal changes fell into the normal reference rang. It is evident from our results that in cases iodine deficiency in the organism, there is a tendency to raise the sensitivity thyrocytes to TSH stimulation rather than a rise in the concentration of circulating TSH. Of all the hormones observed, thyroglobulin was the best indicator of iodine retention in the organism.

Adolescent↗

PubMed2006

[Is decreased thyroid echogenity a good indicator of thyroid autoimmune disorder?].

INTRODUCTION: Thyroid gland with mildly decreased or significantly decreased echogenity is indicating possible autoimmune disorder even before first symptoms, i.e. change in laboratory tests measuring the level of thyroid hormones and antibodies to thyroid antigens occur. TARGET: to consider changes in thyroid gland echogenity suspecting thyroid autoimmune disorder and to determine antibodies to thyroid antigens in the respective type of thyroid echogenity (increased, normal, mildly decreased or significantly decreased) to consider the activity of autoimmune thyropathies related to echogenity and to compare these factors. METHODS: Echogenity of the thyroid gland was examinated in randomly selected population (n = 1 055, 360 male, 695 female) in 11 regions of the Czech republic, all presented with urinary iodine concentration > 100 microg/L of urine. The echogenity was determined in 4-level scale as increased (1), normal (0), mildly decreased (-1) and significantly decreased (-2). Texture of thyroid was evaluated in 2-level scale as homogenous or non-homogenous. For the evaluation of the relation between echogenity type (1 to -2) and TgAb, and between the type of echogenity and TOPAb frequence analysis (logarithm-linear modules) was used, i.e. the complete module was compared with the measured values. RESULTS: The selected adults (695 female, 360 male) with urinary iodine concentration > 100 microg/L of urine presented with increased echogenity in 2 females (0.28%) and 1 male (0.28%), normal echogenity in 281 females (40.42%) and 206 males (57.22%), mildly decreased echogenity in 288 females (41.43%) and 128 males (35.56%) and significantly decreased echogenity in 124 females (17.84%) and 25 males (6.95%). The biggest group, both in males and in females, presented with normal and mildly decreased echogenity. Homogenous thyroid gland structure was found in 223 females (32.08%) and 220 males (61.11%). Non-homogenous texture was found in 472 females (67.92 %) and 140 males (38.89%). Frequence analysis both in males and in females was focused on: 1. relation between the echogenity (ECHO) and TgAb: in females with positive TgAb (14.23%), significant relation to ECHO can be seen (p < 0,0001), in contradiction to males; 2. relation between the echogenity (ECHO) and TPOAb: this relation is very significant both in males and in females (p < 0.0001); 3. mutual relation between TgAb and TPOAb: both in males and in females very significant (p < 0.0001); positive relation between antibodies can be seen. Positive presence of antibodies can be found less frequent, negative presence of both antibodies is more frequent; 4. relation between the echogenity, TgAb and TPOAb: no statistic significance was found. CONCLUSION: Homogenous thyroid gland structure was mainly found in males and, on the contrary, non-homogenous structure in females. In 52.7% of adults with significantly decreased echogenity, autoimmune disorder was confirmed in laboratory tests at the same time. With echogenity increasing, TgAb and TPOAb decreased, vice versa. Sonography, evaluating decreased echogenity, can be an early indicator of serious thyropathies before function parameters and clinical symptoms appear. Detected risky adults with sonographic signs of autoimmune disorder have to be monitored and respective treatment considered and started at the very first occurence of positive antibodies even if the function is still normal.

Adult↗

PubMed2006

[Prevalence of C-reactive protein levels in adult population in two regions in the czech republic and their relation to body composition].

UNLABELLED: Increased concentration of high sensitivity C-reactive protein (hsCRP) is the new predictor of myocardial infarction, brain strokes, damage peripheral veins and sudden death. The aim of the study was to give an overview of current prevalence of individual risky concentrations of hsCRP in the adult population in two regions in the Czech Republic and to find a relationship to the indicators of fat tissue quantity. METHODS: test involved a representative sample of 516 adults aged 18 to 65 years (191 men and 322 women), with permanent residence in the Jablonec nad Nisou a Príbram regions. Period of testing: spring of 2004 and 2005. HsCRP was determined using the latex immunoprecipitation method with turbidimetric measurement on Cobas Integra 400 plus analyzer. The risk of cardiovascular disease (CVD) was set according to the scale derived by the American Heart Association. Body fat was measured with TANITA BF 410 MA, Omron and a calliper on 4 places on the body. Waist circumference was measured half-way between the anthropometric landmarks of the iliocristale and the lower angle of the ribs. Body mass index (BMI) was calculated using Quetelet formula: weight/height2. Statistical processing was done with Statgraphics Plus, version 7.1, using categorical data analysis with the chi2 statistic and Spearman's correlation analysis. RESULTS: 20.2% of cases with high CVD risk were identified in the whole sample of adults. Levels of hsCRP exceeding 10 mg/l (infectious disease indicator) at the time of the test were found in 3.9% cases (5.6% in the Jablonec region, 2.3% in the Príbram region). There were no significant regional differences for individual CVD risk categories; however, there was statistically significant difference between the two regions in terms of average hsCRP levels (with higher levels in the Jablonec region). Gender had a statistically significant impact on hsCRP levels: high CVD risk was recorded in 14.8% men and in 23.3% women. Levels of CRP indicating inflammatory disease were more frequent in women (4.7%) than in men (2.6%). The frequency of risk levels of hsCRP in adults significantly grows with age. Spearman's correlation analysis showed the closest relationship between hsCRP and body fat weight (r(S) = 0.5124). A statistically important positive CRP levels relationship was shown both in subcutaneous fat and visceral fat. CONCLUSION: One fifth of the adult population in two regions of the Czech Republic have at the present time levels of hsCRP which indicate a high cardiovascular risk. The risk is higher in women than in men and it doubles starting at 50 years of age and over. Positive correlation between hsCRP levels and body fat indicators was conformed both for visceral and subcutaneous fat.

Adiposity↗

PubMed2000

Does a relationship exist between ioduria, magnesiuria and calciuria?

We investigated the mutual relations between ioduria in the one hand, and calciuria, magnesiuria, and creatininuria, on the other hand in a randomly selected group of the population of the Czech Republic. The individual parameters were always determined in the sample of monitoring urine after night fasting, concentration according to the WHO/ICCIDD, we observed a parallel increase of calciuria, magnesiuria and creatininuria. The values of calciuria, magnesiuria and creatininuria correlated positively with ioduria both in children and in adults aged 6-93 years without any statistical effect of sex.

Adolescent↗

PubMed1999

Status of magnesium, selenium and iodine saturation in the population of seven regions in the Czech Republic.

In seven regions of the Czech Republic the magnesiuria and calciuria were determined photometrically using the apparatus Merck Vitalab Eclipse, the selenuria fluorimetrically and the ioduria photometrically after alkaline mineralization in the morning sample of urine (after night fasting) in subjects aged 6-65 years (3,587 probands) selected at random. The lowest magnesiuria was found in children in Klatovy district (5.36 nmol/l +/- 0.11) and the highest magnesiuria was estimated in children from the Ustí nad Labem district (6.59 mmol/l +/- 0.16). In adults the lowest magnesiuria was in Vsetín region (3.78 mmol/l +/- 0.08). Selenuria was lowest in Jindrichüv Hradec (7.60 micrograms/l +/- 0.30) and highest in the Vsetín district (15.07 micrograms/l +/- 0.50). Adults had the lowest selenuria in the region Jindrichüv Hradec (7.67 micrograms/l +/- 0.30) and the highest in Ustí nad Orlicí (11.68 micrograms/l +/- 0.34). The lowest ioduria was estimated in children from Ustí nad Labem (94.30 micrograms/l +/- 2.06) and the highest in the Vsetín region (151.60 micrograms/l +/- 7.55). Adults from the district Jindrichüv Hradec had ioduria merely (77.7 micrograms/l +/- 2.18) and the highest ioduria was found in probands from the Znojmo region (123.30 micrograms/l +/- 4.47). As far as the dependence on age is concerned, the magnesiuria significantly decreases both in children and in adults with the increasing age. Selenuria decreases in adults significantly with growing age. Sex-related differences were estimated in children aged 6 years where girls had significantly lower selenuria than boys and girls aged 13 years had lower ioduria, magnesiuria and selenuria than boys. Women aged 18-35 years had significantly lower ioduria, calciuria and magnesiuria in comparison with men of the same age. Women have a significantly lower ioduria in comparison with men at the age 56-65 years.

Adolescent↗

PubMed1998

[The effect of age on levels of magnesium and creatinine in the urine].

BACKGROUND: The concentration of magnesium in urine reflects its intake from food resources. The main regulatory mechanism of magnesium homeostasis is the kidney filtration-absorption process. So far the reference values are not known of the magnesium concentration in urine in dependence on age and sex for the normal population. Therefore, we focused on investigating these problems in a randomly selected sample of persons of both sexes, aged 1-93 years. Beside magnesiuria we also assessed creatininuria. METHODS AND RESULTS: The selection of 2715 persons of both sexes aged from one to ninety three years was made by the random selection method. As we have found no statistically significant difference between men and women as regards concentrations of magnesium and creatinine in urine, the evaluated groups include persons of both sexes. The whole is divided into age groups as follows: children 1 year (n = 24), 2 years (n = 15), 4 years (n = 18), 6 years (n = 378), 10 years (n = 424), 13 years (n = 416), and adults 18-35 years (n = 396), 36-49 years (n = 482), 50-65 years (n = 453), 66-75 years (n = 53), 76-85 years (n = 42), 86-93 years (n = 14). In the morning urine after twelve-hour fasting we determined the concentration of magnesium and creatinine be using Merck Vitalab Eclipse apparatus. The concentration of magnesium in urine rises from 3.37 +/- 0.28 mmol/l at 1 years to the top value 6.64 +/- 0.58 mmol/l (p < 0.001) at 4 years, and since this age it is continuously dwindling to the value 2.35 +/- 0.17 mmol/l (p < 0.001) at the age of 93 years. The creatinine concentration in urine rises from 2.47 +/- 0.30 mmol/l at the age of one year to 15.33 +/- 0.36 mmol/l (p < 0.001) in the age group 18-35 years, and further it goes down with age to the value 6.23 +/- 0.99 mmol/l (p < 0.001) at 93 years. The highest ratio of the urine concentrations of magnesium and creatinine 1.98 +/- 0.32 is at the age of 2 years, and then it is continuously subsiding to 0.41 +/- 0.15 (p < 0.001) at the age range 66-75 years. CONCLUSIONS: When evaluating the magnesium concentration in urine as the index of a sufficient supply of organism with this ion, and also in various studies of metabolism, it is essential to consider the patient's age. The ratio of cocentrations in urine of magnesium and creatinine does not improve the meaningfulness of magnesium analysis.

Adolescent↗

PubMed1998

Calciuria, magnesiuria and creatininuria--relation to age.

We assessed the concentration of calcium, magnesium and creatinine in 2715 samples of the first morning urine. The investigation comprised the following age groups: children one, two, four, six, ten and thirteen years old, and groups of adults aged 18-35, 36-49, 50-65, 66-75, 76-85 and 86-93 years. The choice was made by random selection of participants of both sexes from diverse regions of the Czech Republic. We found the age to have a marked influence on the value of calcium, magnesium and creatinine, including urinary concentration ratios of calcium/creatinine and magnesium/creatinine. The urinary calcium concentration was low both in the early and advanced age groups, while it reached peak values in subjects 18-35 years old. The urinary magnesium concentration was also age-dependent, with a maximum in children aged 4 years, and a subsequent decline with advancing age. The value of the ratio urinary calcium/creatinine and urinary magnesium/creatinine was highest in the youngest age group (1-4 years).

Adolescent↗

PubMed1998

[Clinical development of unstable (brittle) diabetes mellitus, its therapy and prognosis].

Treatment of labile (brittle) diabetes characterized by variations of the blood sugar level, liability to develop ketoacidosis and in susceptible subjects the development of organ complications, was always a serious problem. The objective of the present work is to evaluate the results of a long-term study concerned with the relationship of compensation, vascular and neurological complications of labile insulin-dependent diabetics. The authors investigated indicators of compensation, and in collaboration with an ophthalmologist, and neurologist also signals of possible damage of the eye, central and peripheral nerves, kidneys. The results achieved by treatment were evaluated systematically. Consistent with the actual situation, treatment with conventional insulin or less common regimes were selected, and the authors reacted also to findings pertaining to organ complications. The cause of lability was assessed and eliminated. During the average period of treatment of 10.6 +/- 2.7 years a significant (p < 0.001) drop of glycated haemoglobin occurred from the baseline value of 12.3 +/- 2.5% to 8.8 +/- 1.3%. The development of organ complications can be influenced favourably to certain extent in particular by satisfactory control of diabetes during the first 10 years of the disease. Treatment is ensured in collaboration with a neurologist, ophthalmologist and indicators of glomerular and tubular kidney function are monitored. The assumption was confirmed that at present it is possible to treat successfully labile (brittle) diabetes and eliminate deteriorating the life of diabetics.

Adult↗

PubMed1998

[Ultrasound densitometry of the heel bone in a random sample of the adult Czech population].

To assess the state of the skeleton of 870 subjects selected at random the authors used ultrasound densitometry of the talus. The assessment was made using a Cuba Clinical apparatus (McCue Ultrasonic Ltd.UK). The assessed parameters were BUA in db/MHz (broad band ultrasound attenuation) and VOS in m/s (velocity of sound). From the results it is apparent that the BUA values in men reach their peak at the age of 31-35 years. In women the BUA values are highest between 18 and 20 years, then follows a decline and again a rise between 41 and 45 years. The VOS values in men are highest between 18 and 20 years, followed by a drop and slight increase between 56 and 60 years. In women the VOS values reach their maximum between 18 and 20 years. The assessed values obtained in a random sample of the population from three regions are the basis for evaluation of bone densitometry obtained by means of questionnaire in the adult Czech population.

Adult↗

PubMed1996

Morning magnesiuria: relation to age and sex.

Magnesium, calcium and creatinine concentration were assessed in the morning urine sample of 1710 subjects randomly selected from the population register in the Czech Republic: children aged 6, 10 and 13 years old and adults in age groups 18-35 years, 36-50 years, and 51-65 years of adults. The groups comprised 911 females and 799 males. There was a marked impact of age on the urinary magnesium concentration in both sexes, the concentration declining with advancing age. The child groups differed significantly from the adults. The urinary magnesium/creatinine ratio declined with age with the exception of the oldest group. The urinary calcium concentration did not change significantly with age in women or men. There was a weak age dependence in the calcium/creatinine ratio.

Adolescent↗

PubMed1996

[Changes in urinary calcium and magnesium levels during supplementation with iodine and selenium].

The authors examined 31 children aged 10-13 years before and after 5-month administration of 100 micrograms iodine (as iodide 100 Merck) and 57 university students (age 18-23 years) divided into four groups. The control group of 15 students received placebo daily, 20 students took selenium (50 micrograms selenium Merck), 8 students iodine (100 micrograms iodide) and 14 students a combination of equal amounts of both elements. The authors investigated the calciuria, mangesiuria and calcium/creatinine ratio and magnesium/creatinine ratio. They found a significant drop of magnesiuria in school children after iodine intake, and in university students there was a significant drop of the magnesium/creatinine ratio in iodine and selenium treated groups as well as those who received a combination of both elements. In the latter group there was also a significant drop of the urinary calcium/creatinine ratio. The findings assembled in a relatively small group of children and students is considered preliminary. It suggests, however, the possible influence of supplementation with iodine and selenium in commonly used amounts on calcium and magnesium excretion. Changes in the control group may be due to seasonal influences.

Adolescent↗

PubMed1995

[The effect of insufficient iodine intake on the size and function of the thyroid gland].

BACKGROUND: The supply of iodine indisputably affects the function of the thyroid gland. It is not clear, however, as to what extent a moderate iodopenia affects common thyroid parameters. OBJECTIVES, STARTING POINT AND MAIN PURPOSE: The aim of the study is to evaluate the influence of iodopenia (ioduria below 50 micrograms of iodine per litre of urine) on the values of T4, T3, TSH, the ankle-jerk time and sonographically ascertained thyroid gland volume in randomly selected sample of Czech population from 4 regions. METHODS: Ioduria was assessed by means of Sandel-Kolthoff method, total thyroxine, triiodothyronine and thyreotropic hormone by immunoluminiscence method; the volume of the thyroid gland sonographically according to Gutekunst and the ankle-jerk reflex by electromagnetic record method. RESULTS: Iodopenia affects a majority of investigated parameters in dependence on age. T4 is significantly higher in iodopenic adults, T3 is significantly higher in iodopenic children, TSH is significantly higher in iodopenic adults and the ankle-jerk time is prolonged in iodopenic adults. The statistical significance of the effect of iodopenia on the volume of thyroid gland was not proved. CONCLUSION: Iodopenia of a mediate degree affects commonly used parameters of the thyroid gland function in dependence on age and other factors which are to be more precisely analyzed using a larger sample. The statistical significance of the effect of iodopenia on the volume of thyroid gland was not proved. (Tab. 1, Fig. 5, Ref. 13.).

Adult↗

PubMed1994

Changes of calcemia and magnesemia during oral glucose tolerance test (OGTT) in relation to glucose tolerance.

We have examined 56 subjects with normal glucose tolerance (NGT), 33 with impaired glucose tolerance (IGT) and 15 diabetics type II (DM) by an oral glucose tolerance test with 75 g of glucose and in addition to glycemia and C-peptide we estimated also calcemia, magnesemia, ionized calcium level (plus corrected ionized calcium level) in all time intervals. The basal glycemia and C-peptide values were different in each examined group, while the magnesium values distinguished only the DM group from the others. The corrected Ca2+ in 60 min decreased significantly in DM, while after 120 min there were no differences in the values. Magnesemia in NGT decreased after 60 and 120 min, while by IGT and DM it rised in both such intervals. The difference between IGT and DM was highly significant. Our findings give evidence about the changes in the distribution of magnesium already at an early stage of decrease glucose tolerance. The importance of this finding for an early IGT diagnostics and its further classification still remains to be definitely evaluated.

Adult↗

PubMed1994

[Comparison of basic somatometric characteristics in randomly selected populations from Prague and Vsetín].

In 1991-1992 in the Czech Republic an epidemiological survey was conducted focused on prevention of iodine deficiency and the incidence of some thyropathies. The authors examined samples of the Prague and Vsetín population selected at random. The clinical examination comprised also somatometric assessment. In a group of 1,100 subjects from Prague and Vsetín anthropometry of basic somatometric characteristics was performed (height, body weight, BMI and four skinfolds). From comparison of the two groups ensues that the Vsetín population is shorter, as compared with the Prague population, the BMI values are significantly higher and so is the percentage of subcutaneous body fat.

Adolescent↗

PubMed1992

The effect of body fat distribution on cardiovascular risk factors in the population of the Czech Republic.

A study of cardiovascular risk factors including anthropometry was performed as part of the MONICA project in 1988 in the population of six districts of the Czech Republic. In addition to probands' weight and height, the circumferences of waist and hips were measured to calculate the index of body fat distribution given as WHR (wast/hip ratio). In the age group of 25-64 years, WHR was significantly higher in men (0.936) than in women (0.836 - p < 0.001); in either sex, its value rose with increasing age. WHR values were statistically significantly higher in this group than those found in a Finnish population where males aged 25-64 years had a mean WHR value of 0.90 (p < 0.001), and women of the same age group had a mean WHR of 0.78 (p < 0.001). An analysis of the relationship between abdominal obesity and some cardiovascular risk factors revealed significant correlations between WHR and total cholesterol (men: r = 0.112, p < 0.001; women: r = 0.122, p < 0.001), HDL cholesterol (men: r = -0.184, p < 0.001; women = -0.23, p < 0.001); atherogenic index, i.e., total cholesterol/HDL cholesterol (men: r = 0.183, p < 0.001; women: r = 0.345, p < 0.001), systolic blood pressure (men: r = 0.295, p < 0.001; women: r = 0.263, p < 0.001), diastolic blood pressure (men: r = 0.32, p < 0.001; women: r = 0.237, p < 0.001). The closest correlation was demonstrated between WHR and BMI (men: r = 0.525, p < 0.001; women r = 0.345, p < 0.001). The authors believe WHR is an important parameter for cardiovascular risk assessment and should be determined on a routine basis. The frequent prevalence of abdominal obesity, as suggested by the high values of WHR, contributes to the high cardiovascular risk of the population of the Czech Republic.

Adult↗