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Biomedical subjects

J Charbonneau

Publications and source records attributed to J Charbonneau.

13 recordsLinked to original sources
PubMed1991

[Is chemotherapy with cisplatin useful in non small cell bronchial cancer at staging IV? Results of a randomized study].

The benefit of chemotherapy for patients with disseminated non small cell lung cancer (NSCLC) is controversial. The introduction of cisplatinum in the combination chemotherapy for NSCLC gave rise to higher response rates. To study the question of the usefulness of cisplatinum-based chemotherapy in disseminated NSCLC we conducted a prospective randomized trial comparing best supportive care to vindesine + cisplatin. Between December 1985 and March 1988, 49 patients with stage IV NSCLC were enrolled. Of the 46 eligible patients 24 were in the chemotherapy group and 22 in the best supportive care group. The treatment groups were not significantly different in terms of age, performance status, histology. Toxicity on the chemotherapy arm grade 3 or more was observed in 17.5% for neutropenia, in 8.75% for vomiting. There was one death related to treatment. The overall response rate in the chemotherapy group was 41.7%. Patients of the chemotherapy group had a median survival time of 199 days and the patients of the best supportive care group had a median survival time of 73 days. The difference in survival is highly significant (p less than 0.001).

Adult↗
PubMed1987

Adjunctive strategies to enhance peripheral warming: clinical techniques.

This study investigates common successful strategies to increase peripheral temperature with biofeedback. Eighteen BCIA-certified therapists (average years of practice, 7.5) were interviewed by telephone for 30 to 45 minutes regarding successful peripheral warming strategies. The practitioners reported using multiple teaching strategies, either concurrently or sequentially. These responses were organized into an interrelated four-category model that consists of the following: (1) Attentional Category--shifting from active to passive attention; (2) General Arousal Category--shifting from hyper- to hypoarousal; (3) Proprioceptive/Kinesthetic Awareness Category--shifting from decreased to increased body awareness; (4) Self-Image/Self-Esteem Category--shifting from negative to positive self-image/self-esteem. These four categories and their corresponding techniques can be used to facilitate peripheral warming.

Biofeedback, Psychology↗
PubMed1981

[Current deaths due to tuberculosis in France. Analysis of 126 deaths recorded in tuberculosis sufferers in 1975 and 1976 in the Bas-Rhin region (author's transl)].

The authors present a study involving 103 cases of death during active tuberculosis and 23 cases of death as a result of complications related to sequelae of tuberculosis recorded in the Bas-Rhin region in 1975 and 1976. Whilst amongst these 103 deaths, the majority concerned elderly individuals, there were nevertheless 20% of deaths due to tuberculosis below the age of 55. The majority of these tuberculosis sufferers had advanced pulmonary lesions where specific therapy had not had time to act. A certain number of deaths could have been avoided, even in the elderly subjects. Of the 23 cases of death due to sequelae, 2/3 died of respiratory failure and 1/5 of secondary aspergillus infection, illustrating the grave prognosis in certain sequelae of tuberculosis.

Adult↗
PubMed1978

[Hereditary antithrombin III deficiency causing recurrent thrombo-embolic problems (author's transl)].

A marked deficiency in antithrombin III (AT III) was demonstrated in a 39-year-old man suffering from recurrent thrombo-embolic problems. The patient's father had died following a thrombo-embolic disorder. A certain number of members of the family also showed evidence of a marked decrease in AT III levels. Although it was not possible to study the patient's parents, it would seem reasonable to conclude that the diagnosis was one of hereditary deficiency in AT III. The various aspects of this disorder discovered by Egeberg are reviewed: early onset, in several members of the same family, or recurrent thrombo-embolic problems, accompanied by a decrease in functional activity of one of the principal inhibitors of thrombin (AT III), with autosomal dominant transmission and treatment based upon anti-vitamin K agents.

Adult↗