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Biomedical subjects

J Chebat

Publications and source records attributed to J Chebat.

At least 19 recordsLinked to original sources
PubMed1995

Role of genetic factors in bronchial cancer. Based upon a case of anaplastic lung carcinoma in identical twins.

Having observed homozygotic identical twin brothers suffering simultaneously from anaplastic bronchial cancer leading rapidly to death in both cases, the authors assessed the frequency of such cases. The available literature failed to reveal any identical observations, although four cases of twins suffering from bronchial cancer featuring different histologies (three epidermoidal and one bronchiolar-alveolar) were noted. Statistics show that, in the area where the observed twins were living, anaplastic cancer occurs each year in 0.39% of 53-year-old men. The case of these twins therefore supports the idea of the role of genetic factors in the determination of bronchial cancer.

Bronchial Neoplasms↗
PubMed1989

Concurrent anaplastic bronchial cancer in identical twin brothers.

After having observed homozygotic identical twin brothers who simultaneously suffered from anaplastic bronchial cancer which rapidly led to death in both cases, the authors assess the frequency of such cases. Review of the available literature failed to produce identical observations, although 4 cases of twins suffering from bronchial cancer with differing histologies (3 epidermoidal and 1 bronchiolar-alveolar) were noted. Statistics show that in the area where the observed twins were living, anaplastic cancer occurs each year in 0.39 of 53-year-old men. The cases of these twins therefore support the notion of the role of genetic factors in the determination of bronchial cancer.

Carcinoma, Bronchogenic↗
PubMed1987

[Genetic factors in the development of bronchial cancer. Apropos of a pair of identical twins].

An anaplastic bronchial cancer was observed to occur simultaneously in identical twin brothers, with a rapidly fatal outcome. This led to authors to appraise the prevalence of such cases and to study the role of genetic factors in the determining bronchial cancer. A review of the literature has not revealed an identical case, on the other hand 4 twin pairs suffered from a bronchial cancer with a different histology (3 epidermoid and 1 bronchoalveolar) were reported. Familial cases of bronchial cancer were also recorded. The authors go on to allude to the intervention of genetic factors in the defense mechanisms of the lung: mucociliary clearance, immunological defense and the role of aryl hydrocarbon hydroxylase. The precise identification of these factors remains difficult on account of their interaction with environmental factors.

Bronchial Neoplasms↗
PubMed1985

[Pneumopathies caused by hypersensitivity to amiodarone and associated nephropathies. Study by alveolar lavage].

Four cases of amiodarone-induced restrictive, hypoxaemic lung disease are described. The cumulative dosages of amiodarone were relatively low (30 to 100 g). Alveolar lavage studies showed a lymphocytosis and study of the lymphocytic sub-populations showed an increase in the OKT8 group, and an inversion of the OKT4/OKT8 ratio. The outcome was favourable on withdrawal of amiodarone and steroid therapy. The immunological origin of this form of lung disease was confirmed. Two patients had renal failure; in the first case, hypercalcaemia, hyperphosphoremia and renal calcification were observed. The second patient had endo- and extracapillary glomerulonephritis with C3 deposits and circulating immune complexes. Renal failure regressed in both cases on withdrawal of amiodarone and with steroid therapy.

Acute Kidney Injury↗
PubMed1982

[Cystic fibrosis and pregnancy].

The authors point out the problems that are raised when a patient with cystic fibrosis becomes pregnant. Pregnancy in a patient with cystic fibrosis is rare but these patients do not seem to have diminished fertility. So it is likely that in the future this combination will increase in frequency. The genetic risk is raised. Heterozygotic subjects are about 3 to 5% of the population and there is a risk of 1 in 4 that heterozygotic parents who already have one child with cystic fibrosis will have a second. The BM test and the sweat test are used to screen for the disease at birth. The pregnancy does not always progress well. The level of prematurity is more than 26% and perinatal mortality is 11%. Furthermore, the birthweight of these children is at the lower limits of normal. Finally, the pregnancy makes the mother's state worse with an increase in her lung signs and change in her respiratory function. On the other hand, diabetes seems to be easily controlled. In conclusion, pregnancy seems to be detrimental for these patients.

Adult↗
PubMed1978

[Pulmonary emphysema and hepatic involvement by alpha-1 antitrypsin deficiency in two adults with a PiZ phenotype (author's transl)].

Two unreleated adult males were found to be suffering from an association of pan-lobular severe emphysema and hepatomegally of unknown origin which led to the discovery of a marked deficit in alpha-1 antitrypsin (A1-AT) in relation to a PiZ phenotype. Liver biopsy revealed cirrhosis with portal fibrosis in one case and in both cases fatty infiltration with the accumulation of a glycoprotein antigenically identical to A1-AT. Electron microscopy showed this protein to be situated within the dilated lumina of the endoplasmic reticulum of the hepatocytes. A1-AT deficiency is usually associated with pulmonary involvement only in the adult and liver involvement only in the child. The association of the two remains rare--hence the interest of the two cases reported.

Adult↗