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Biomedical subjects

J Chell

Publications and source records attributed to J Chell.

15 recordsLinked to original sources
PubMed1999

Work practices and histopathological changes in the tenosynovium and flexor retinaculum in carpal tunnel syndrome in women.

We studied 58 women of employable age with the carpal tunnel syndrome in order to determine whether the histological appearances of the carpal tunnel, tenosynovium and flexor retinaculum are influenced by work practices. Age, body mass index and the duration of symptoms did not correlate with the extent of oedema or fibrosis within the tenosynovium. The incidence of abnormality on histological examination of the tenosynovium was the same in employed and unemployed patients (p = 1.0), and was not influenced by the level of repetition (p = 0.89) or force (p = 0.29) of work. Myxoid degeneration within the flexor retinaculum was, however, more common in women undertaking 'high-force' work. Apart from this finding, the results suggest that work practices do not affect tenosynovial thickening, fibrosis or oedema in patients with carpal tunnel syndrome.

Adult↗
PubMed1998

Migration and failure of the Mecron screw-in acetabular prosthesis.

Early results with the Mecron prosthesis have been variable. We report our experience with this prosthesis at medium- to long-term follow-up. At 5 to 9 years after surgery, 43 patients (49 implants) were reviewed. Radiographic measurements of superior migration, alteration in the opening angle, and thread engagement were made. The failure rate was very high, 33% having been revised or awaiting revision. Of the remainder, 80% had migrated, 86% had changes in the opening angle, and 65% had fewer threads engaged. Many have low-grade symptoms insufficient to merit revision, but the extent of loosening makes eventual revision likely. We feel this represents an example of a new design gaining widespread usage before adequate follow-up studies.

Acetabulum↗
PubMed1998

Pollicisation of the index finger. A 27-year follow-up study.

We have reviewed 11 patients with congenital absence of the thumb, treated by pollicisation of the index finger, after follow-up for 20 to 38 years. Seven of the hands also had an associated radial club-hand deformity. Function as assessed by the Percival score was excellent in six, good in three, fair in two and poor in four; three of the poor results were in patients with radial club hand. Ten of the 15 transfers were used as normal thumbs, but in five hands function required trick movements. Of the seven unilateral cases, two transplants were used as the dominant hand, and in another two thumb strength was more than 50% of that on the opposite side. For patients with isolated congenital absence of the thumb, pollicisation of the index finger gives good functional and cosmetic results which are maintained. The results are less reliable for those with radial club hand.

Activities of Daily Living↗
PubMed1987

The effect of hydrocortisone on the para-aortic body of the newborn mouse: an in vivo fraction of labelled mitoses study.

Information about the cell cycle of the mouse para-aortic body within the first 24 hours of postnatal life was derived from a fraction of labelled mitoses study. The total cell cycle time was 8 1/2 hours, being made up as follows: S phase-2 hours; G2 phase-1 hour; M phase-3 1/2 hours (by analysis of the results, not by assumption) and G1 phase-2 hours (by subtraction). Problems are discussed regarding the length of G2 and M phases and the consequences for G1. After hydrocortisone administration (40 mg/kg/day) to female mice for the last seven days of pregnancy, the pattern in newborn mice was disrupted. Values for G2 and M were similar to those of the untreated group, but no values were obtainable for the other phases of the cell cycle or for the total cell cycle time. These results after hydrocortisone treatment could be explained by the superimposition of the cell cycles of two or more different groups of cells. They are discussed with regard to the life span of the para-aortic body, and their implications are considered in the light of previously reported glucocorticoid-induced transformations of small granule cells from cervical sympathetic ganglia into catecholamine-storing chromaffin cells. The established hyperplastic effect of hydrocortisone on the para-aortic body is therefore not the result simply of an acceleration of the cell cycle, but it may involve the incorporation into the proliferative compartment of cells previously either moribund or nonproliferating.

Animals↗