Biomedical subjects

J Chlubnová

Publications and source records attributed to J Chlubnová.

4 recordsLinked to original sources

PubMed2005

Visual evoked potentials and event related potentials in congenitally deaf subjects.

The purpose was to test parameters of visual evoked potentials (VEPs) and of event-related potentials (ERPs) in deaf subjects to verify visual and cognitive CNS functions in a handicapped group of the population. Three types of visual stimuli (with dominating parvocellular or magnocellular system activation or with cognitive tasks) were used in the study. Six deaf persons (4 women, 2 men, mean age 17 years) and 6 persons with normal hearing (sex- and age-matched) were included in this pilot study. In all types of stimulation, latencies and amplitudes of main VEPs and ERPs components were evaluated. No significant latency differences were found. However, significantly reduced amplitudes were found in the occipital area for responses to motion and cognitive stimuli which might be interpreted as a part of functional reorganization of the extrastriate and cognitive cortical areas of deaf subjects.

Adolescent↗

PubMed2005

Influence of physiological changes of glycaemia on VEPs and visual ERPs.

Since hypoglycemia is known to influence cognitive functions, we checked whether the physiological changes in glycemia (after fasting or exertion) can explain the rather high intra-individual variability of event-related potentials (ERPs). Besides the ERPs to "change in coherence of a moving pattern" with reaction time (RT) recording, binocular pattern reversal VEPs and motion-onset VEPs (to linear and radial motion) were also examined in 14 healthy subjects prior to and after 24-h fasting that decreased glycemia from 5.3 to 3.9 mmol/l on the average. We only found one significant change in the latencies and amplitudes of VEPs and ERPs (with no change of RT). The N160 peak in the motion-onset VEPs to radial (expansive) motion (EM-VEPs) showed a larger amplitude at lower glycemia. For evaluation of the exertion influence, we tested glycemia prior to and after 90 min long exercise -- bicycle ergometry with the load set to 2 W/kg in women and 2.5 W/kg in men (average age-related values for W170/kg index). The changes of glycemia to exertion were, however, less distinct than those to fasting. We conclude that in healthy subjects the glycemia decrease due to 24-h fasting or intensive time-limited exercise never reaches the critical value to change the VEP, ERPs and RTs.

Adolescent↗

PubMed2004

Effect of stimulus localisation on motion-onset VEP.

Reliable motion-onset visual evoked potentials (result of the dorsal stream activation) were recorded to motion stimuli with the temporal frequency of five cycles per seconds in 20 different locations with eccentricity up to 42 degrees to periphery of the visual field. Amplitudes and latencies of the positive-negative-positive (P1-N1-P2; 84-144-208 ms) complex were evaluated in occipital (OZ and two derivations 5 cm to the left and right from OZ) and central region (CZ) in 10 subjects. We observed: (1) Shortening of the N1 latency toward periphery of the visual field. (2) The N1 amplitude maximum and latency minimum moved from occipital into central region (CZ derivation) as stimulus moved from centre toward periphery of visual field. (3) The P1 and N1 peaks displayed significantly greater amplitudes and shorter latencies when the lower part of the visual field was stimulated. (4) The N1 peak changed lateralisation of its maximum amplitude in dependence on the eccentricity. Up to 17 degrees, it corresponds to striate projection of the "optic radiation" whilst more in periphery, there was paradoxical lateralisation of higher amplitude and shorter latency. The retinotopic dependence shows that the motion response includes position information and that the motion-onset VEPs are not generated solely in the higher extrastriate areas (MT or MST).

Adult↗

PubMed2002

Visual event-related potentials to moving stimuli: normative data.

Visual cognitive responses (P300) to moving stimuli were tested in 36 subjects with the aim to find the normal range of P300 parameters. Concomitantly, the circadian intra-individual variability of the P300 was studied in a subgroup of 6 subjects. Visual stimuli consisted of either coherent (frequent stimulus) or non-coherent motion (random stimulus). The oddball paradigm was applied for recording cognitive responses. P300 to rare stimuli had an average latency of 447.3 +/- 46.6 ms and amplitude of 12.9 +/- 6.0 microV. The average reaction time was in the range from 322 to 611 ms and there was no correlation between the reaction time and P300 latency. We did not find any significant circadian changes of the P300 parameters in the 6 subjects tested four times during the same day. Cognitive (event-related) responses (P300) displayed distinctly greater inter-individual variability (S.D. of 50 ms) when compared with pattern-reversal and motion-onset VEPs (S.D. of 6.0 ms and 14 ms, respectively). For this reason, the clinical use of P300 elicited by this kind of visual stimuli seems to be rather restricted and the evaluation of its intra-individual changes is preferable.

Adult↗